Patterning the Vertebrate Neuraxis

• Andrew Lumsden

  A. Lumsden is in the Medical Research Council Brain Development Programme, Department of Developmental Neurobiology, United Medical and Dental Schools, Guy's Hospital, London SE1 9RT, UK.

• Robb Krumlauf

  R. Krumlauf is in the Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW17 1AA, UK.

Abstract

Neuraxial patterning is a continuous process that extends over a protracted period of development. During gastrulation a crude anteroposterior pattern, detectable by molecular markers, is conferred on the neuroectoderm by signals from the endomesoderm that are largely inseparable from those of neural induction itself. This coarse-grained pattern is subsequently reinforced and refined by diverse, locally acting mechanisms. Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.

Journal

• Science

  Science 274 1109-1115, 1996-11-15

  American Association for the Advancement of Science (AAAS)

Keywords

• Multidisciplinary

Details

• CRID: 1360011145284161280
• NII Article ID: 80009333449
• DOI: 10.1126/science.274.5290.1109
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/01934511
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.274.5290.1109
• Data Source:
  • Crossref
  • CiNii Articles