Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

DOI Web Site 被引用文献140件
  • Henry Markram
    H. Markram and B. Sakmann, Max-Planck-Institut für Medizinische Forschung, Abteilung Zellphysiologie, Jahnstraße 29, D-69120 Heidelberg, Germany.
  • Joachim Lübke
    J. Lübke and M. Frotscher, Anatomisches Institut der Albert-Ludwigs Universität Freiburg, Albertstraße 17, D-79104 Freiburg, Germany.
  • Michael Frotscher
    J. Lübke and M. Frotscher, Anatomisches Institut der Albert-Ludwigs Universität Freiburg, Albertstraße 17, D-79104 Freiburg, Germany.
  • Bert Sakmann
    H. Markram and B. Sakmann, Max-Planck-Institut für Medizinische Forschung, Abteilung Zellphysiologie, Jahnstraße 29, D-69120 Heidelberg, Germany.

抄録

<jats:p>Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons.</jats:p>

収録刊行物

  • Science

    Science 275 (5297), 213-215, 1997-01-10

    American Association for the Advancement of Science (AAAS)

被引用文献 (140)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ