The Roles of γ1 Heavy Chain Membrane Expression and Cytoplasmic Tail in IgG1 Responses

DOI Web Site 被引用文献15件
  • Tsuneyasu Kaisho
    Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany.
  • Frieder Schwenk
    Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany.
  • Klaus Rajewsky
    Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany.

抄録

<jats:p>In antibody responses, B cells switch from the expression of immunoglobulin (Ig) μ and δ heavy (H) chains to that of other Ig classes (α, γ, or ɛ), each with a distinct effector function. Membrane-bound forms of α, γ, and ɛ, but not μ and δ, have highly conserved cytoplasmic tails. Mutant mice unable to express membrane γ1 H chains or producing tailless γ1 H chains failed to generate efficient IgG1 responses and IgG1 memory. H chain membrane expression after class switching is thus required for these functions, and class switching equips the B cell antigen receptor with a regulatory cytoplasmic tail that naı̈ve B cells lack.</jats:p>

収録刊行物

  • Science

    Science 276 (5311), 412-415, 1997-04-18

    American Association for the Advancement of Science (AAAS)

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