Identification of α-Fodrin as a Candidate Autoantigen in Primary Sjögren's Syndrome

• Norio Haneji

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Takanori Nakamura

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Koji Takio

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Kumiko Yanagi

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Hiroyuki Higashiyama

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Ichiro Saito

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Sumihare Noji

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Hiromu Sugino

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

• Yoshio Hayashi

  N. Haneji, K. Yanagi, H. Higashiyama, I. Saito, Y. Hayashi, Department of Pathology, Tokushima University School of Dentistry, 3 Kuramotocho, Tokushima 770, Japan.

抄録

It is unclear whether organ-specific autoantigens are critical for the development of primary Sjögren’s syndrome (SS). A 120-kilodalton organ-specific autoantigen was purified from salivary gland tissues of an NFS/ sld mouse model of human SS. The amino-terminal residues were identical to those of the human cytoskeletal protein α-fodrin. The purified antigen induced proliferative T cell responses and production of interleukin-2 and interferon-γ in vitro. Neonatal immunization with the 120-kilodalton antigen prevented the disease in mice. Sera from patients with SS reacted positively with purified antigen and recombinant human α-fodrin protein, whereas those from patients with systemic lupus erythematosus and rheumatoid arthritis did not. Thus, the immune response to 120-kilodalton α-fodrin could be important in the initial development of primary SS.

収録刊行物

• Science

  Science 276 (5312), 604-607, 1997-04-25

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1361699995779346432
• NII論文ID: 80009616714
• DOI: 10.1126/science.276.5312.604
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.276.5312.604
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