Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
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- Dong Liu
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Josie Diorio
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Beth Tannenbaum
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Christian Caldji
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Darlene Francis
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Alison Freedman
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Shakti Sharma
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Deborah Pearson
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Paul M. Plotsky
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
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- Michael J. Meaney
- D. Liu, J. Diorio, B. Tannenbaum, C. Caldji, D. Francis, A. Freedman, S. Sharma, D. Pearson, M. J. Meaney, Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada H4H 1R3.
抄録
<jats:p> Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic corticotropin-releasing hormone messenger RNA. Each measure was significantly correlated with the frequency of maternal licking and grooming (all <jats:italic>r</jats:italic> 's > −0.6). These findings suggest that maternal behavior serves to “program” hypothalamic-pituitary-adrenal responses to stress in the offspring. </jats:p>
収録刊行物
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- Science
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Science 277 (5332), 1659-1662, 1997-09-12
American Association for the Advancement of Science (AAAS)
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詳細情報 詳細情報について
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- CRID
- 1360292619041469312
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- NII論文ID
- 80009876610
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- ISSN
- 10959203
- 00368075
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- データソース種別
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- Crossref
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