IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
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- Frank Mercurio
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Hengyi Zhu
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Brion W. Murray
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Andrej Shevchenko
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Brydon L. Bennett
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Jian wu Li
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- David B. Young
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Miguel Barbosa
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Matthias Mann
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Anthony Manning
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
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- Anjana Rao
- F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
抄録
<jats:p>Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A large multiprotein complex, the IκB kinase (IKK) signalsome, was purified from HeLa cells and found to contain a cytokine-inducible IκB kinase activity that phosphorylates IκB-α and IκB-β. Two components of the IKK signalsome, IKK-1 and IKK-2, were identified as closely related protein serine kinases containing leucine zipper and helix-loop-helix protein interaction motifs. Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-κB–dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-κB signaling pathway.</jats:p>
収録刊行物
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- Science
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Science 278 (5339), 860-866, 1997-10-31
American Association for the Advancement of Science (AAAS)
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詳細情報
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- CRID
- 1360011144827428992
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- NII論文ID
- 80009965104
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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