IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

  • Frank Mercurio
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Hengyi Zhu
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Brion W. Murray
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Andrej Shevchenko
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Brydon L. Bennett
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Jian wu Li
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • David B. Young
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Miguel Barbosa
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Matthias Mann
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Anthony Manning
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.
  • Anjana Rao
    F. Mercurio, H. Zhu, B. W. Murray, B. Bennett, J. Li, D. Young, M. Barbosa, A. Manning, Signal Pharmaceuticals, Inc., 5555 Oberlin Drive, San Diego, CA 92121, USA.

抄録

<jats:p>Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A large multiprotein complex, the IκB kinase (IKK) signalsome, was purified from HeLa cells and found to contain a cytokine-inducible IκB kinase activity that phosphorylates IκB-α and IκB-β. Two components of the IKK signalsome, IKK-1 and IKK-2, were identified as closely related protein serine kinases containing leucine zipper and helix-loop-helix protein interaction motifs. Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-κB–dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-κB signaling pathway.</jats:p>

収録刊行物

  • Science

    Science 278 (5339), 860-866, 1997-10-31

    American Association for the Advancement of Science (AAAS)

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