CD1d-Restricted and TCR-Mediated Activation of V <sub>α</sub> 14 NKT Cells by Glycosylceramides

DOI Web Site 被引用文献220件
  • Tetsu Kawano
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Junqing Cui
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Yasuhiko Koezuka
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Isao Toura
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Yoshikatsu Kaneko
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Kazuhiro Motoki
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Hitomi Ueno
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Ryusuke Nakagawa
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Hiroshi Sato
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Eisuke Kondo
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Haruhiko Koseki
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
  • Masaru Taniguchi
    T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.

抄録

<jats:p> Natural killer T (NKT) lymphocytes express an invariant T cell antigen receptor (TCR) encoded by the V <jats:sub>α</jats:sub> 14 and J <jats:sub>α</jats:sub> 281 gene segments. A glycosylceramide-containing α-anomeric sugar with a longer fatty acyl chain (C <jats:sub>26</jats:sub> ) and sphingosine base (C <jats:sub>18</jats:sub> ) was identified as a ligand for this TCR. Glycosylceramide-mediated proliferative responses of V <jats:sub>α</jats:sub> 14 NKT cells were abrogated by treatment with chloroquine–concanamycin A or by monoclonal antibodies against CD1d/V <jats:sub>β</jats:sub> 8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein. Thus, this lymphocyte shares distinct recognition systems with either T or NK cells. </jats:p>

収録刊行物

  • Science

    Science 278 (5343), 1626-1629, 1997-11-28

    American Association for the Advancement of Science (AAAS)

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