Cleavage of the BMP-4 Antagonist Chordin by Zebrafish Tolloid

DOI Web Site 被引用文献6件
  • Patrick Blader
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.
  • Sepand Rastegar
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.
  • Nadine Fischer
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.
  • Uwe Strähle
    Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.

抄録

<jats:p> Dorsoventral patterning of vertebrate and <jats:italic>Drosophila</jats:italic> embryos requires bone morphogenetic proteins (BMPs) and antagonists of BMP activity. The <jats:italic>Drosophila</jats:italic> gene <jats:italic>tolloid</jats:italic> encodes a metalloprotease similar to BMP-1 that interacts genetically with <jats:italic>decapentaplegic</jats:italic> , the <jats:italic>Drosophila</jats:italic> homolog of vertebrate BMP-2/4. Zebrafish embryos overexpressing a zebrafish homolog of <jats:italic>tolloid</jats:italic> were shown to resemble loss-of-function mutations in <jats:italic>chordino</jats:italic> , the zebrafish homolog of the <jats:italic>Xenopus</jats:italic> BMP-4 antagonist Chordin. Furthermore, Chordin was degraded by COS cells expressing Tolloid. These data suggest that Tolloid antagonizes Chordin activity by proteolytically cleaving Chordin. A conserved function for zebrafish and <jats:italic>Drosophila</jats:italic> Tolloid during embryogenesis is proposed. </jats:p>

収録刊行物

  • Science

    Science 278 (5345), 1937-1940, 1997-12-12

    American Association for the Advancement of Science (AAAS)

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