Identification of a Nuclear Receptor for Bile Acids

DOI Web Site 被引用文献117件
  • Makoto Makishima
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235–9050, USA.
  • Arthur Y. Okamoto
    Tularik Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA.
  • Joyce J. Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235–9050, USA.
  • Hua Tu
    Tularik Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA.
  • R. Marc Learned
    Tularik Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA.
  • Alvin Luk
    Tularik Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA.
  • Mitchell V. Hull
    Tularik Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA.
  • Kevin D. Lustig
    Tularik Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA.
  • David J. Mangelsdorf
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235–9050, USA.
  • Bei Shan
    Tularik Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA.

抄録

<jats:p>Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7α-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid–binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.</jats:p>

収録刊行物

  • Science

    Science 284 (5418), 1362-1365, 1999-05-21

    American Association for the Advancement of Science (AAAS)

被引用文献 (117)*注記

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