Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

DOI Web Site 被引用文献60件
  • J. Holash
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
  • P. C. Maisonpierre
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
  • D. Compton
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
  • P. Boland
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
  • C. R. Alexander
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
  • D. Zagzag
    Microvascular and Molecular Neuro-Oncology Laboratory, Department of Pathology, Kaplan Cancer Center, New York University Medical Center, New York, NY 10016, USA.
  • G. D. Yancopoulos
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
  • S. J. Wiegand
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

抄録

<jats:p>In contrast with the prevailing view that most tumors and metastases begin as avascular masses, evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels. This coopted host vasculature does not immediately undergo angiogenesis to support the tumor but instead regresses, leading to a secondarily avascular tumor and massive tumor cell loss. Ultimately, however, the remaining tumor is rescued by robust angiogenesis at the tumor margin. The expression patterns of the angiogenic antagonist angiopoietin-2 and of pro-angiogenic vascular endothelial growth factor (VEGF) suggest that these proteins may be critical regulators of this balance between vascular regression and growth.</jats:p>

収録刊行物

  • Science

    Science 284 (5422), 1994-1998, 1999-06-18

    American Association for the Advancement of Science (AAAS)

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