The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

DOI Web Site 被引用文献77件
  • Arash Grakoui
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Shannon K. Bromley
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Cenk Sumen
    Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
  • Mark M. Davis
    Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
  • Andrey S. Shaw
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Paul M. Allen
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  • Michael L. Dustin
    Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

抄録

<jats:p>The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor–ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.</jats:p>

収録刊行物

  • Science

    Science 285 (5425), 221-227, 1999-07-09

    American Association for the Advancement of Science (AAAS)

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