Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

• D. W. Dawson

  Department of Microbiology-Immunology,

• O. V. Volpert

  Department of Microbiology-Immunology,

• P. Gillis

  Department of Microbiology-Immunology,

• S. E. Crawford

  Department of Pathology,

• H.-J. Xu

  Department of Molecular Oncology,

• W. Benedict

  Department of Genitourinary Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.

• N. P. Bouck

  Department of Microbiology-Immunology,

抄録

In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because of the action of angiogenic inhibitors that prevent vessels from invading the cornea and vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments is identified as pigment epithelium–derived factor (PEDF), a protein previously shown to have neurotrophic activity. The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization. These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness.

収録刊行物

• Science

  Science 285 (5425), 245-248, 1999-07-09

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360564063943014272
• NII論文ID: 80011200651
• DOI: 10.1126/science.285.5425.245
• ISSN: 10959203
• ISSN: 00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.285.5425.245
• データソース種別:
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