薬理ゲノミクスと創薬科学

• 田中 利男

  三重大学医学部薬理学教室

• 西村 有平

  三重大学医学部薬理学教室

• 角田 宏

  三重大学医学部薬理学教室

• 中 充子

  三重大学医学部薬理学教室

書誌事項

タイトル別名

• PHARMACOGENOMICS AND DRUG DISCOVERY

抄録

Gene sequensing and gene expression are of particular significance in pharmacogenomics. Sequencing is used to locate polymorphisms, and monitoring of gene expression can provide clue about the genomic response to disease and treatment. Then, we used gene expression profile analysis to identify therapeutic target genes by studying change of gene expression in animal models of oxidative stress and hypoxia. Oxidative stress and hypoxia are important in the pathogenesis of various diseases. We found novel drug target candidates in oxidative stress and hypoxia through this pharmacogenomic strategy. Our results suggest that the pharmacogenomics have the potential for strategy to define novel drug targets in various diseases.

収録刊行物

• 薬物動態

  薬物動態 14 (supplement), 64-67, 1999

  日本薬物動態学会

詳細情報

• CRID: 1390282679646663424
• NII論文ID: 130003561111
• NII論文ID: 80011354840
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.14.supplement_64
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/14/supplement/14_supplement_64/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000091399
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可