Functions of Cell Surface Heparan Sulfate Proteoglycans

• Merton Bernfield

  Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115;

• Martin Götte

  Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115;

• Pyong Woo Park

  Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115;

• Ofer Reizes

  Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115;

• Marilyn L. Fitzgerald

  Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115;

• John Lincecum

  Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115;

• Masahiro Zako

  Division of Developmental and Newborn Biology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115;

抄録

▪ Abstract  The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide-linked glypicans, bind these ligands and enhance formation of their receptor-signaling complexes. These heparan sulfate proteoglycans also immobilize and regulate the turnover of ligands that act at the cell surface. The extracellular domains of these proteoglycans can be shed from the cell surface, generating soluble heparan sulfate proteoglycans that can inhibit interactions at the cell surface. Recent analyses of genetic defects in Drosophila melanogaster, mice, and humans confirm most of these activities in vivo and identify additional processes that involve cell surface heparan sulfate proteoglycans. This chapter focuses on the mechanisms underlying these activities and on the cellular functions that they regulate.

収録刊行物

• Annual Review of Biochemistry

  Annual Review of Biochemistry 68 (1), 729-777, 1999-06

  Annual Reviews

キーワード

• Biochemistry

詳細情報

• CRID: 1362262944166093952
• NII論文ID: 80011363804
• DOI: 10.1146/annurev.biochem.68.1.729
• ISSN: 15454509
• ISSN: 00664154
• Web Site: https://www.annualreviews.org/doi/pdf/10.1146/annurev.biochem.68.1.729
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