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- Kirio Kawai
- Section of Molecular Neurobiology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Chemistry, Asahi University School of Dentistry, 1851-1 Hozumi, Motosu-gun, Gifu 501-0296, Japan; National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8642, Japan; and Section of Oral Neuroscience, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka...
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- Kumiko Sugimoto
- Section of Molecular Neurobiology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Chemistry, Asahi University School of Dentistry, 1851-1 Hozumi, Motosu-gun, Gifu 501-0296, Japan; National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8642, Japan; and Section of Oral Neuroscience, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka...
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- Kiyohito Nakashima
- Section of Molecular Neurobiology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Chemistry, Asahi University School of Dentistry, 1851-1 Hozumi, Motosu-gun, Gifu 501-0296, Japan; National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8642, Japan; and Section of Oral Neuroscience, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka...
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- Hirohito Miura
- Section of Molecular Neurobiology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Chemistry, Asahi University School of Dentistry, 1851-1 Hozumi, Motosu-gun, Gifu 501-0296, Japan; National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8642, Japan; and Section of Oral Neuroscience, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka...
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- Yuzo Ninomiya
- Section of Molecular Neurobiology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Chemistry, Asahi University School of Dentistry, 1851-1 Hozumi, Motosu-gun, Gifu 501-0296, Japan; National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8642, Japan; and Section of Oral Neuroscience, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka...
抄録
<jats:p> Leptin acts as a potent inhibitory factor against obesity by regulating energy expenditure, food intake, and adiposity. The obese diabetic <jats:italic>db</jats:italic> / <jats:italic>db</jats:italic> mouse, which has defects in leptin receptor, displays enhanced neural responses and elevated behavioral preference to sweet stimuli. Here, we show the effects of leptin on the peripheral taste system. An administration of leptin into lean mice suppressed responses of peripheral taste nerves (chorda tympani and glossopharyngeal) to sweet substances (sucrose and saccharin) without affecting responses to sour, salty, and bitter substances. Whole-cell patch-clamp recordings of activities of taste receptor cells isolated from circumvallate papillae (innervated by the glossopharyngeal nerve) demonstrated that leptin activated outward K <jats:sup>+</jats:sup> currents, which resulted in hyperpolarization of taste cells. The <jats:italic>db</jats:italic> / <jats:italic>db</jats:italic> mouse with impaired leptin receptors showed no such leptin suppression. Taste tissue (circumvallate papilla) of lean mice expressed leptin-receptor mRNA and some of the taste cells exhibited immunoreactivities to antibodies of the leptin receptor. Taken together, these observations suggest that the taste organ is a peripheral target for leptin, and that leptin may be a sweet-sensing modulator (suppressor) that may take part in regulation of food intake. Defects in this leptin suppression system in <jats:italic>db</jats:italic> / <jats:italic>db</jats:italic> mice may lead to their enhanced peripheral neural responses and enhanced behavioral preferences for sweet substances. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 97 (20), 11044-11049, 2000-09-19
Proceedings of the National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1363107371175894528
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- NII論文ID
- 80012079360
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- ISSN
- 10916490
- 00278424
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- データソース種別
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