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- Kazuhiro Tateda
- <!--label omitted: 1-->Department of Microbiology, Toho University School of Medicine, Tokyo, Japan,1 and
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- Rachel Comte
- <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2
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- Jean-Claude Pechere
- <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2
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- Thilo Köhler
- <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2
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- Keizo Yamaguchi
- <!--label omitted: 1-->Department of Microbiology, Toho University School of Medicine, Tokyo, Japan,1 and
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- Christian Van Delden
- <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2
抄録
<jats:title>ABSTRACT</jats:title> <jats:p> We report that 2 μg of azithromycin/ml inhibits the quorum-sensing circuitry of <jats:italic>Pseudomonas aeruginosa</jats:italic> strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes <jats:italic>lasR</jats:italic> and <jats:italic>rhlR</jats:italic> but not that of the autoinducer synthase-encoding gene <jats:italic>lasI</jats:italic> . We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production. </jats:p>
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 45 (6), 1930-1933, 2001-06
American Society for Microbiology
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詳細情報 詳細情報について
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- CRID
- 1362544420892614784
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- NII論文ID
- 80012320967
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- ISSN
- 10986596
- 00664804
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- データソース種別
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