Azithromycin Inhibits Quorum Sensing in <i>Pseudomonas aeruginosa</i>

• Kazuhiro Tateda

  <!--label omitted: 1-->Department of Microbiology, Toho University School of Medicine, Tokyo, Japan,1 and

• Rachel Comte

  <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2

• Jean-Claude Pechere

  <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2

• Thilo Köhler

  <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2

• Keizo Yamaguchi

  <!--label omitted: 1-->Department of Microbiology, Toho University School of Medicine, Tokyo, Japan,1 and

• Christian Van Delden

  <!--label omitted: 2-->Department of Microbiology and Genetics, University of Geneva, Geneva, Switzerland2

抄録

We report that 2 μg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI . We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

収録刊行物

• Antimicrobial Agents and Chemotherapy

  Antimicrobial Agents and Chemotherapy 45 (6), 1930-1933, 2001-06

  American Society for Microbiology

キーワード

• Infectious Diseases
• Pharmacology (medical)
• Pharmacology

詳細情報

• CRID: 1362544420892614784
• NII論文ID: 80012320967
• DOI: 10.1128/aac.45.6.1930-1933.2001
• ISSN: 10986596
• ISSN: 00664804
• Web Site: https://journals.asm.org/doi/pdf/10.1128/AAC.45.6.1930-1933.2001
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