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- Neil F. Bence
- Department of Biological Sciences, Stanford University, Stanford, CA 94305–5020, USA.
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- Roopal M. Sampat
- Department of Biological Sciences, Stanford University, Stanford, CA 94305–5020, USA.
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- Ron R. Kopito
- Department of Biological Sciences, Stanford University, Stanford, CA 94305–5020, USA.
抄録
<jats:p>Intracellular deposition of aggregated and ubiquitylated proteins is a prominent cytopathological feature of most neurodegenerative disorders. Whether protein aggregates themselves are pathogenic or are the consequence of an underlying molecular lesion is unclear. Here, we report that protein aggregation directly impaired the function of the ubiquitin-proteasome system. Transient expression of two unrelated aggregation-prone proteins, a huntingtin fragment containing a pathogenic polyglutamine repeat and a folding mutant of cystic fibrosis transmembrane conductance regulator, caused nearly complete inhibition of the ubiquitin-proteasome system. Because of the central role of ubiquitin-dependent proteolysis in regulating fundamental cellular events such as cell division and apoptosis, our data suggest a potential mechanism linking protein aggregation to cellular disregulation and cell death.</jats:p>
収録刊行物
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- Science
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Science 292 (5521), 1552-1555, 2001-05-25
American Association for the Advancement of Science (AAAS)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360574095215076352
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- NII論文ID
- 80012483708
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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- データソース種別
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- Crossref
- CiNii Articles