Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

• Yaron Hakak

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

• John R. Walker

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

• Cheng Li

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

• Wing Hung Wong

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

• Kenneth L. Davis

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

• Joseph D. Buxbaum

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

• Vahram Haroutunian

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

• Allen A. Fienberg

  Genomics Institute of the Novartis Research Foundation, 3115 Merryfield Row, San Diego, CA 92121; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10021; and Mental Illness Research, Education and Clinical Centers (MIRECC), Bronx Veterans Affairs Medical Center, Bronx, NY 10468

抄録

Neuropathological and brain imaging studies suggest that schizophrenia may result from neurodevelopmental defects. Cytoarchitectural studies indicate cellular abnormalities suggestive of a disruption in neuronal connectivity in schizophrenia, particularly in the dorsolateral prefrontal cortex. Yet, the molecular mechanisms underlying these findings remain unclear. To identify molecular substrates associated with schizophrenia, DNA microarray analysis was used to assay gene expression levels in postmortem dorsolateral prefrontal cortex of schizophrenic and control patients. Genes determined to have altered expression levels in schizophrenics relative to controls are involved in a number of biological processes, including synaptic plasticity, neuronal development, neurotransmission, and signal transduction. Most notable was the differential expression of myelination-related genes suggesting a disruption in oligodendrocyte function in schizophrenia.

収録刊行物

• Proceedings of the National Academy of Sciences

  Proceedings of the National Academy of Sciences 98 (8), 4746-4751, 2001-04-10

  Proceedings of the National Academy of Sciences

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360855569970206080
• NII論文ID: 80012597509
• DOI: 10.1073/pnas.081071198
• ISSN: 10916490
• ISSN: 00278424
• Web Site: https://pnas.org/doi/pdf/10.1073/pnas.081071198
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