Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

DOI Web Site 被引用文献18件
  • Janusz H. S. Kabarowski
    Department of Microbiology, Immunology, and Molecular Genetics;
  • Kui Zhu
    Department of Cancer Biology, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  • Lu Q. Le
    Department of Microbiology, Immunology, and Molecular Genetics;
  • Owen N. Witte
    Department of Microbiology, Immunology, and Molecular Genetics;
  • Yan Xu
    Department of Cancer Biology, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

抄録

<jats:p>Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to a specific cell-surface receptor. We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein–coupled receptor whose genetic ablation results in the development of autoimmunity. Activation of G2A by LPC increased intracellular calcium concentration, induced receptor internalization, activated ERK mitogen-activated protein kinase, and modified migratory responses of Jurkat T lymphocytes. This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis.</jats:p>

収録刊行物

  • Science

    Science 293 (5530), 702-705, 2001-07-27

    American Association for the Advancement of Science (AAAS)

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