Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

DOI Web Site 被引用文献231件
  • Sue C. Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Esther Latres
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Susanne Baumhueter
    Applied Biosystems, 850 Lincoln Center Drive, Foster City, CA 94404, USA.
  • Venus K.-M. Lai
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Lorna Nunez
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Brian A. Clarke
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • William T. Poueymirou
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Frank J. Panaro
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Erqian Na
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Kumar Dharmarajan
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Zhen-Qiang Pan
    Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY, 10029–6574, USA.
  • David M. Valenzuela
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Thomas M. DeChiara
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • Trevor N. Stitt
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • George D. Yancopoulos
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.
  • David J. Glass
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591–6707, USA.

抄録

<jats:p> Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models. Two of these genes encode ubiquitin ligases: <jats:italic>Muscle RING Finger 1</jats:italic> ( <jats:italic>MuRF1</jats:italic> ), and a gene we designate <jats:italic>Muscle Atrophy F-box</jats:italic> ( <jats:italic>MAFbx</jats:italic> ), the latter being a member of the SCF family of E3 ubiquitin ligases. Overexpression of <jats:italic>MAFbx</jats:italic> in myotubes produced atrophy, whereas mice deficient in either <jats:italic>MAFbx</jats:italic> or <jats:italic>MuRF1</jats:italic> were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy. </jats:p>

収録刊行物

  • Science

    Science 294 (5547), 1704-1708, 2001-11-23

    American Association for the Advancement of Science (AAAS)

被引用文献 (231)*注記

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