Complete genome sequence of <i>Clostridium perfringens</i> , an anaerobic flesh-eater

  • Tohru Shimizu
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Kaori Ohtani
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Hideki Hirakawa
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Kenshiro Ohshima
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Atsushi Yamashita
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Tadayoshi Shiba
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Naotake Ogasawara
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Masahira Hattori
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Satoru Kuhara
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...
  • Hideo Hayashi
    Department of Microbiology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Hitachi Instruments Service Company, Limited, Yotsuya, Shinjuku, Tokyo 160-0004, Japan; School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan; Advanced Institute of Science and Technology, Nara, Ikoma 630-0101,...

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<jats:p> <jats:italic>Clostridium perfringens</jats:italic> is a Gram-positive anaerobic spore-forming bacterium that causes life-threatening gas gangrene and mild enterotoxaemia in humans, although it colonizes as normal intestinal flora of humans and animals. The organism is known to produce a variety of toxins and enzymes that are responsible for the severe myonecrotic lesions. Here we report the complete 3,031,430-bp sequence of <jats:italic>C. perfringens</jats:italic> strain 13 that comprises 2,660 protein coding regions and 10 rRNA genes, showing pronounced low overall G + C content (28.6%). The genome contains typical anaerobic fermentation enzymes leading to gas production but no enzymes for the tricarboxylic acid cycle or respiratory chain. Various saccharolytic enzymes were found, but many enzymes for amino acid biosynthesis were lacking in the genome. Twenty genes were newly identified as putative virulence factors of <jats:italic>C. perfringens</jats:italic> , and we found a total of five hyaluronidase genes that will also contribute to virulence. The genome analysis also proved an efficient method for finding four members of the two-component VirR/VirS regulon that coordinately regulates the pathogenicity of <jats:italic>C. perfringens</jats:italic> . Clearly, <jats:italic>C. perfringens</jats:italic> obtains various essential materials from the host by producing several degradative enzymes and toxins, resulting in massive destruction of the host tissues. </jats:p>

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