Twenty One Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2A6 Gene in Japanese and Caucasians
-
- KIYOTANI Kazuma
- Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
- FUJIEDA Masaki
- Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
- YAMAZAKI Hiroshi
- Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
-
- SHIMADA Tsutomu
- Osaka Prefectural Institute of Public Health
-
- GUENGERICH F. Peter
- Vanderbilt University School of Medicine
-
- PARKINSON Andrew
- Xenotech
-
- NAKAGAWA Kazuko
- Kumamoto University
-
- ISHIZAKI Takashi
- Kumamoto University
-
- KAMATAKI Tetsuya
- Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University
Bibliographic Information
- Other Title
-
- Twenty one novel single polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians
Search this article
Abstract
We sequenced all nine exons and exon-intron junctions of the CYP2A6 gene from 33 Japanese and 28 Caucasians. We found twenty one single nucleotide polymorphisms (SNPs) including four SNPs causing amino acid substitutions, one silent SNP in exon 5, one SNP in a 5′-flanking region, four SNPs in a 3′-untranslated region, and eleven SNPs in introns. The four mutations (13G>A and 86G>A in exon 1, and 2134A>G and 2161C>T in exon 4) causing amino acid substitutions (Gly5Arg, Ser29Asn, Lys194Glu, and Arg203Ser), respectively, were as follows: SNP, 020719Kiyotani004; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008.4; LENGTH, 25 base; 5′-ATGCTGGCCTCAG/AGGATGCTTCTGG-3′. SNP, 020719Kiyotani005; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008.4; LENGTH, 25 base; 5′-AGCAGAGGAAGAG/ACAAGGGGAAGCT-3′. SNP, 020719Kiyotani011; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008.4; LENGTH, 25 base; 5′-CGCTTTGACTATA/GAGGACAAAGAGT-3′. SNP, 020719Kiyotani012; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008.4; LENGTH, 25 base; 5′-CTGTCACTGTTGC/TGCATGATGCTAG-3′. New alleles having these SNPs were designated as CYP2A6∗13-CYP2A6∗16.<br>
Journal
-
- Drug Metabolism and Pharmacokinetics
-
Drug Metabolism and Pharmacokinetics 17 (5), 482-487, 2002
The Japanese Society for the Study of Xenobiotics
- Tweet
Details 詳細情報について
-
- CRID
- 1390282680157470848
-
- NII Article ID
- 130004462853
- 80015733216
-
- NII Book ID
- AA1162652X
-
- ISSN
- 18800920
- 13474367
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed