Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

DOI Web Site 被引用文献376件
  • Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230–0045, Japan.
  • Takashi Nomura
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606–8507, Japan.
  • Shimon Sakaguchi
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230–0045, Japan.

抄録

<jats:p> Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that <jats:italic>Foxp3</jats:italic> , which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4 <jats:sup>+</jats:sup> regulatory T cells. Furthermore, retroviral gene transfer of <jats:italic>Foxp3</jats:italic> converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4 <jats:sup>+</jats:sup> regulatory T cells. Thus, <jats:italic>Foxp3</jats:italic> is a key regulatory gene for the development of regulatory T cells. </jats:p>

収録刊行物

  • Science

    Science 299 (5609), 1057-1061, 2003-02-14

    American Association for the Advancement of Science (AAAS)

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