Relationship between Exercise Training-Induced Increase in Insulin Sensitivity and Adiponectinemia in Healthy Men
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- YATAGAI TOSHIMITSU
- Division of Endocrinology and Metabolism, Jichi Medical School
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- NISHIDA YUICHIRO
- Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University
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- NAGASAKA SHOICHIRO
- Division of Endocrinology and Metabolism, Jichi Medical School
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- NAKAMURA TOMOATSU
- Division of Endocrinology and Metabolism, Jichi Medical School
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- TOKUYAMA KUMPEI
- Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Science, University of Tsukuba
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- SHINDO MUNEHIRO
- Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University
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- TANAKA HIROAKI
- Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University
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- ISHIBASHI SHUN
- Division of Endocrinology and Metabolism, Jichi Medical School
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抄録
Circulating concentrations of adiponectin, an adipocyte-derived protein, are increased by thiazolidinediones and by weight reduction, accompanied with improvement in insulin sensitivity. The effect of exercise training, another therapy to increase insulin sensitivity (SI), on adiponectinemia is currently unclear. The present study was undertaken to clarify whether exercise training-induced increase in SI is related to changes in adiponectinemia in healthy men. Twelve healthy non-obese men underwent ergometer training at lactate threshold (LT) intensity for 60 min/day for 5 days/week for 6 weeks. An insulin-modified intravenous glucose tolerance test was performed before and at 16 h and 1 week after the last training session to determine SI using a minimal-model approach. Serum levels of adiponectin were determined at the same time. After the exercise training, Vo2max and LT were significantly increased by 7.2% and 22.3% (P<0.01), while BMI and body fat mass remained unchanged. SI was significantly increased at 16 h after the last training session (from 7.0 ± 3.1 to 9.6 ± 3.6 [×10-4·(μU/ml)-1·min-1], P<0.01), but returned toward the basal levels at 1 week after the cessation of the training. Serum adiponectin concentrations before the training (20.9 ± 7.4 μg/ml) were positively correlated with SI. The concentrations were slightly but significantly decreased at 16 h (17.2 ± 6.6 μg/ml, P<0.05), and returned to the basal values at 1 week after the training. From these results, it can be concluded that exercise training-induced increase in SI is not dependent on the increase in adiponectinemia in healthy men.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 50 (2), 233-238, 2003
一般社団法人 日本内分泌学会
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詳細情報
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- CRID
- 1390282681274999680
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- NII論文ID
- 130004443035
- 80015931926
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- NII書誌ID
- AA10901436
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- COI
- 1:CAS:528:DC%2BD3sXltlSgt7c%3D
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- ISSN
- 13484540
- 09188959
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- PubMed
- 12803245
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可