Relationship between Exercise Training-Induced Increase in Insulin Sensitivity and Adiponectinemia in Healthy Men

  • YATAGAI TOSHIMITSU
    Division of Endocrinology and Metabolism, Jichi Medical School
  • NISHIDA YUICHIRO
    Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University
  • NAGASAKA SHOICHIRO
    Division of Endocrinology and Metabolism, Jichi Medical School
  • NAKAMURA TOMOATSU
    Division of Endocrinology and Metabolism, Jichi Medical School
  • TOKUYAMA KUMPEI
    Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Science, University of Tsukuba
  • SHINDO MUNEHIRO
    Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University
  • TANAKA HIROAKI
    Laboratory of Exercise Physiology, Faculty of Health and Sports Science, Fukuoka University
  • ISHIBASHI SHUN
    Division of Endocrinology and Metabolism, Jichi Medical School

この論文をさがす

抄録

Circulating concentrations of adiponectin, an adipocyte-derived protein, are increased by thiazolidinediones and by weight reduction, accompanied with improvement in insulin sensitivity. The effect of exercise training, another therapy to increase insulin sensitivity (SI), on adiponectinemia is currently unclear. The present study was undertaken to clarify whether exercise training-induced increase in SI is related to changes in adiponectinemia in healthy men. Twelve healthy non-obese men underwent ergometer training at lactate threshold (LT) intensity for 60 min/day for 5 days/week for 6 weeks. An insulin-modified intravenous glucose tolerance test was performed before and at 16 h and 1 week after the last training session to determine SI using a minimal-model approach. Serum levels of adiponectin were determined at the same time. After the exercise training, Vo2max and LT were significantly increased by 7.2% and 22.3% (P<0.01), while BMI and body fat mass remained unchanged. SI was significantly increased at 16 h after the last training session (from 7.0 ± 3.1 to 9.6 ± 3.6 [×10-4·(μU/ml)-1·min-1], P<0.01), but returned toward the basal levels at 1 week after the cessation of the training. Serum adiponectin concentrations before the training (20.9 ± 7.4 μg/ml) were positively correlated with SI. The concentrations were slightly but significantly decreased at 16 h (17.2 ± 6.6 μg/ml, P<0.05), and returned to the basal values at 1 week after the training. From these results, it can be concluded that exercise training-induced increase in SI is not dependent on the increase in adiponectinemia in healthy men.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 50 (2), 233-238, 2003

    一般社団法人 日本内分泌学会

被引用文献 (8)*注記

もっと見る

参考文献 (28)*注記

もっと見る

詳細情報

問題の指摘

ページトップへ