Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

DOI Web Site 被引用文献26件
  • Tor D. Wager
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • James K. Rilling
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • Edward E. Smith
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • Alex Sokolik
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • Kenneth L. Casey
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • Richard J. Davidson
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • Stephen M. Kosslyn
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • Robert M. Rose
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.
  • Jonathan D. Cohen
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109–1109, USA.

抄録

<jats:p>The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations. Thus, placebo treatments that have no intrinsic pharmacological effects may produce analgesia by altering expectations. However, controversy exists regarding whether placebos alter sensory pain transmission, pain affect, or simply produce compliance with the suggestions of investigators. In two functional magnetic resonance imaging (fMRI) experiments, we found that placebo analgesia was related to decreased brain activity in pain-sensitive brain regions, including the thalamus, insula, and anterior cingulate cortex, and was associated with increased activity during anticipation of pain in the prefrontal cortex, providing evidence that placebos alter the experience of pain.</jats:p>

収録刊行物

  • Science

    Science 303 (5661), 1162-1167, 2004-02-20

    American Association for the Advancement of Science (AAAS)

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