Positive correlation between androgen and the endocrine-disruptor bisphenol A, in normal women and women with ovarian dysfunction

• TAKEUCHI Toru

  Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo CREST, Japan Science and Technology

• TSUTSUMI Osamu

  Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo CREST, Japan Science and Technology

• IKEZUKI Yumiko

  Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo CREST, Japan Science and Technology

• TAKAI Yasushi

  Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo CREST, Japan Science and Technology

• TAKETANI Yuji

  Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo

書誌事項

タイトル別名

• Positive Relationship between Androgen and the Endocrine Disruptor, Bisphenol A, in Normal Women and Women with Ovarian Dysfunction

抄録

This study was performed to investigate the serum levels of bisphenol A (BPA), an endocrine disruptor, in women with ovarian dysfunction and obesity. Fasting serum samples were obtained from 19 non-obese and 7 obese women with normal menstrual cycles: 7 patients with hyperprolactinemia, 21 patients with hypothalamic amenorrhea, and 13 non-obese and 6 obese patients with polycystic ovary syndrome (PCOS). BPA was measured by an enzyme-linked immunosorbent assay. BPA was detected in all human sera. Serum BPA concentrations were significantly higher in both non-obese and obese women with polycystic ovary syndrome (1.05 ± 0.10 ng/ml, 1.17 ± 0.16 ng/ml; p<0.05, respectively) and obese normal women (1.04 ± 0.09 ng/ml, p<0.05) compared with those in non-obese normal women (0.71 ± 0.09 ng/ml). There was no difference among women with hyperprolactinemia, women with hypothalamic amenorrhea, and non-obese normal women. There were significant positive correlations between serum BPA and total testosterone (r = 0.391, p<0.001), free testosterone (r = 0.504, p<0.001), androstenedione (r = 0.684, p<0.001), and DHEAS (r = 0.514, p<0.001) concentrations in all subjects. These findings show that there is a strong relationship between serum BPA and androgen concentrations, speculatively due to the effect of androgen on the metabolism of BPA. <br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 51 (2), 165-169, 2004

  一般社団法人 日本内分泌学会

キーワード

• Bisphenol A
• Polycystic ovary syndrome
• Hyperprolactinemia
• Hypothalamic amenorrhea
• Obesity

詳細情報

• CRID: 1390282681275980928
• NII論文ID: 130004443112
• NII論文ID: 80016601016
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.51.165
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 15118266
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/51/2/51_2_165/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004257340
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可