The complete genomic sequence of <i>Nocardia farcinica</i> IFM 10152
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- Jun Ishikawa
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
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- Atsushi Yamashita
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
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- Yuzuru Mikami
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
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- Yasutaka Hoshino
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
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- Haruyo Kurita
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
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- Kunimoto Hotta
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
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- Tadayoshi Shiba
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
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- Masahira Hattori
- Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan; Laboratory of Genomic Information, Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan; and Department of Molecular Function, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba-shi, Chiba 260-8673, Japan
書誌事項
- タイトル別名
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- The complete genomic sequence of Nocardia farcinica IFM 10152.
抄録
<jats:p> We determined the genomic sequence of <jats:italic>Nocardia farcinica</jats:italic> IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 101 (41), 14925-14930, 2004-10-04
Proceedings of the National Academy of Sciences