Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)
-
- Ryu-ichi Fukuda
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Ayako Hayashi
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Atae Utsunomiya
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Yuko Nukada
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Rie Fukui
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Katsuhiko Itoh
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Katsunari Tezuka
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Kazumasa Ohashi
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Kensaku Mizuno
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Manabu Sakamoto
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Masahiro Hamanoue
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
-
- Takashi Tsuji
- Department of Biological Science and Technology, Faculty of Industrial Science and Technology, and Tissue Engineering Research Center, Research Institute of Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan; Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Kagoshima 890-0064, Japan; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan; Pharmaceutical Research Laboratory, JT Inc., Takatsuki, Osaka 569-1125,...
抄録
<jats:p>Adult T cell leukemia/lymphoma (ATLL) has been characterized as one of the most aggressive human neoplasias and its incidence is thought to be caused by both genetic and epigenetic alterations to the host cellular genes of T cells infected with human T cell leukemia virus type I (HTLV-I). A multilobulated nuclear appearance is an important diagnostic marker of ATLL, and we have now identified that the molecular mechanisms underlying these formations occur through microtubule rearrangement via phosphatidylinositol 3-kinase (PI3-kinase) activation by AILIM/ICOS signaling. We also show that PTEN and/or SHIP-1, which are PIP3 inositol phosphatases that inhibit the activation of downstream effectors of the PI3-kinase cascade, are disrupted in both ATLL neoplasias and in multilobulated nuclei-forming Jurkat cells. This down-regulation of PTEN was found to be essential for the formation of ATLL-type nuclear lobules. Furthermore, PI3-kinase and PTEN activities were observed to be closely associated with cellular proliferation. Thus, our results suggest that alteration of PI3-kinase signaling cascades, as a result of the down-regulation of inositol phosphatases, induces ATLL-type multilobulated nuclear formation and is also associated with the cellular proliferation of malignant T cell leukemias/lymphomas.</jats:p>
収録刊行物
-
- Proceedings of the National Academy of Sciences
-
Proceedings of the National Academy of Sciences 102 (42), 15213-15218, 2005-10-10
Proceedings of the National Academy of Sciences
- Tweet
キーワード
詳細情報
-
- CRID
- 1363951795454520960
-
- NII論文ID
- 80017610873
-
- ISSN
- 10916490
- 00278424
-
- データソース種別
-
- Crossref
- CiNii Articles
- KAKEN