Changes in systemic type 1 and type 2 immunity in normal pregnancy and pre‐eclampsia may be mediated by natural killer cells

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<jats:title>Abstract</jats:title><jats:p>A bias of T cell immunity towards type 2 (Th2) is thought to be critical for normal pregnancy. Pathological pregnancies, such as pre‐eclampsia, are characterised by cell‐mediated (Th1) immune dominance. The Th1/Th2 paradigm, however, is too simplistic. Normal pregnancy is associated with a systemic inflammatory response which increases throughout gestation. This inflammatory response is exaggerated in pre‐eclampsia, a syndrome of the third trimester. T helper (Th) cells are considered the primary mediators of these altered immune responses, and other T cells, <jats:italic>i.e.</jats:italic> T cytotoxic (Tc) cells, and lymphocytes of the innate immune system, <jats:italic>i.e.</jats:italic> natural killer (NK) and NKT cells, have been largely disregarded. In this study, we have used novel pan type 1 (IL‐18 receptor) and pan type 2 (ST2L) lymphocyte function markers in four‐colour flow cytometry to broadly characterise peripheral blood lymphocyte populations from non‐pregnant, normal pregnant and pre‐eclamptic women. There were no changes in the Th1/Th2 or Tc1/Tc2 cell ratios between the three groups; however, the NK1/NK2 and NKT1/NKT2 cell ratios were significantly decreased in normal pregnancy compared with non‐pregnant (<jats:italic>p </jats:italic><0.001 and <jats:italic>p </jats:italic><0.01, respectively) and pre‐eclamptic women (<jats:italic>p </jats:italic><0.05). These results confirm that immunoregulation occurs in pregnancy, but suggest a dominant role of the innate rather than the adaptive immune system.</jats:p>

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