Genome Streamlining in a Cosmopolitan Oceanic Bacterium

Stephen J. Giovannoni, H. James Tripp, Scott Givan, Mircea Podar, Kevin L. Vergin, Damon Baptista, Lisa Bibbs, Jonathan Eads, Toby H. Richardson, Michiel Noordewier, Michael S. Rappé, Jay M. Short, James C. Carrington, Eric J. Mathur

doi:10.1126/science.1114057

Genome Streamlining in a Cosmopolitan Oceanic Bacterium

DOI Web Site 被引用文献22件

Stephen J. Giovannoni

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
H. James Tripp

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Scott Givan

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Mircea Podar

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Kevin L. Vergin

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Damon Baptista

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Lisa Bibbs

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Jonathan Eads

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Toby H. Richardson

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Michiel Noordewier

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Michael S. Rappé

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Jay M. Short

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
James C. Carrington

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Eric J. Mathur

Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.

抄録

<jats:p> The SAR11 clade consists of very small, heterotrophic marine α-proteobacteria that are found throughout the oceans, where they account for about 25% of all microbial cells. <jats:italic>Pelagibacter ubique</jats:italic> , the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, <jats:italic>P. ubique</jats:italic> has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. <jats:italic>P. ubique</jats:italic> has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell. </jats:p>