Oxidative Stress, Inflammation, and Atherosclerotic Changes in Retinal Arteries in the Japanese Population; Results from the Mima Study

• SAKANE Naoki

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

• FUJIWARA Shinji

  Mima City National Health Insurance Koyadaira Clinic Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University

• SANO Yoshiko

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

• DOMICHI Masayuki

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

• TSUZAKI Kokoro

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

• MATSUOKA Yukiyo

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

• HAMADA Taku

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

• SAIGA Kyoko

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

• KOTANI Kazuhiko

  Division of Preventive Medicine and Diabetes Education, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center

抄録

Oxidative stress and inflammation are known to play roles in the pathogenesis of vascular events. The aim of this study was to investigate the relationship between oxidative stress, inflammation, and atherosclerosis in the general population. A population-based, cross-sectional study was made of 282 people (126 men and 156 women, mean age; 65 13, mean BMI; 25.4 2.7 kg/m ² ) recruited from the Mima study in Tokushima Prefecture. Risk factors included age, sex, body mass index (BMI), cigarette smoking, systolic and diastolic pressure, fasting blood glucose, serum lipids, and high-sensitive C-reactive protein (hs-CRP). Oxidative stress in blood samples was measured by the diacron reactive oxygen metabolites (ROMs) test. The degree of sclerotic change was determined from fundus photographs according to Scheie's classification. After adjustment for age and sex, ROM levels positively correlated with hs-CRP levels, but not with ghrelin, leptin and adiponectin levels. Furthermore, ROM and hs-CRP levels positively and individually correlated with the grade of sclerotic change in the fundus oculi independent of age in a multiple regression analysis. These results suggest that oxidative stress and chronic inflammation promote atherosclerosis in the retinal arteries in the general population. <br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 55 (3), 485-488, 2008

  一般社団法人 日本内分泌学会

キーワード

• Oxidative stress
• C-reactive proteins
• Atherosclerosis
• General population

詳細情報

• CRID: 1390001206299477248
• NII論文ID: 80019611329
• NII論文ID: 130004770078
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k07e-073
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/55/3/55_K07E-073/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008285026
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可