Chemokines in tumor development and progression

Access this Article

Search this Article

Author(s)

Abstract

Chemokines were originally identified as mediators of the inflammatory process and regulators of leukocyte trafficking. Subsequent studies revealed their essential roles in leukocyte physiology and pathology. Moreover, chemokines have profound effects on other types of cells associated with the inflammatory response, such as endothelial cells and fibroblasts. Thus, chemokines are crucial for cancer-related inflammation, which can promote tumor development and progression. Increasing evidence points to the vital effects of several chemokines on the proliferative and invasive properties of tumor cells. The wide range of activities of chemokines in tumorigenesis highlights their roles in tumor development and progression. © 2011 Elsevier Inc. All rights reserved.

Journal

  • Experimental Cell Research

    Experimental Cell Research 318(2), 95-102, 2012-01-15

    Elsevier

Codes

  • NII Article ID (NAID)
    80022173851
  • NII NACSIS-CAT ID (NCID)
    AA00641011
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0014-4827
  • Data Source
    IR 
Page Top