Animal cell biotechnology
著者
書誌事項
Animal cell biotechnology
Academic Press, 1985-
- v. 1
- v. 2
- v. 3
- v. 4
- v. 5
- v. 6
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注記
Includes bibliographies and index
内容説明・目次
- 巻冊次
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v. 5 ISBN 9780126575552
内容説明
The Animal Cell Biotechnology series provides an in-depth state-of-the art coverage of a field which has developed into a multi-billion dollar industry over the last ten years. Written by leading experts, each volume contains well-referenced, fully-indexed reviews on practical and theoretical aspects of a specific subject, including:
Bioreactor design and development
Cell products and their development
Downstream processing
Product testing
The main theme of this volume - applications of animal cells - has been broadened from the recurring theme of production of biologicals to the cells themselves as a product, and cells as a pharmacological/toxicological assay system. The need to replace animals in research and for the testing of drugs, foods and cosmetics is becoming increasingly critical as society has succeeded in making this a high profile ethical issue. It is the perceived belief that the best chance of reducing the use of animals will be to develop suitable assays based on cells in culture. Two chapters in this volume cover replacement animal cells and the use of skin cells for in vitro testing. Other chapters also detail the cell products tPA, Factor VIII, and Growth Factors.
The basic tool is, of course, the cell and the text contains chapters on how to standardize the cell and process in order to achieve reproducible conditions, whether for production or assay purposes. Also featured is a review of immortalization techniques that can be used to construct new cell lines which fulfill the specialized criteria required of them. Finally a chapter on surface active agents is included.
目次
- R.E. Spier, Animal Cell Biotechnology in the 90s: from Models to Morals. C. MacDonald, Isolation of New Animal Cell Lines Using Immortalization Techniques. A. Doyle and J.B. Griffiths, Standardization of Animal Cell Culture Processes. D.J. Benford, The Use of Animal Cells as Replacements for Whole Animals in the Toxicity Testing of Chemicals and Pharmaceuticals. B. Coulomb and L. Dubertret, Production and Use of Skin Cell Cultures for the in Vitro Testing of Chemicals and Pharmaceuticals. A. Burt and D.A. McGrouther, The Production and Use of Skin Cell Cultures in Therapeutic Situations. F.L.J. van Lier, J.M. Vlak, and J. Tramper, Production of Baculovirus-Expressed Proteins from Suspension Cultures of Insect Cells. A.J. Beale, The Production of Viruses for Human Vaccines from Animal Cells in Culture. A.J. MacLeod, Production of Therapeutic Plasma Proteins Using Recombinant Mammalian Cells
- The Example of Coagulation Factor VIII. T. Cartwright, Production of tPA from Animal Cell Cultures. P. Collodi and D.W. Barnes, Production of Growth Stimulating Factors from Animal Cells. A. Handa-Corrigan, S. Zang, and R. Brydges, Surface Active Agents in Animal Cell Cultures. Index.
- 巻冊次
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v. 6 ISBN 9780126575569
内容説明
There has been a dramatic increase in the perception of the value of animal cell biotechnology to the research and manufacturing communities in recent years. This volume seeks to keep the reader up-to-date with this progress. This sixth and final volume in the series concentrates on the biology of animal cells in culture, giving special attention to the relationship between biology and the ability to use such cells productively. As the search continues for greater productivity, there is a need to understand the switches within cells that control expression. Additional abilities to manipulate those switches in a controllable manner are also required. In the last five years, considerable progress has been made in the elucidation of the mechanisms for cell signaling and control of gene expression. The 13 chapters of this volume are devoted to these subjects and to techniques in areas of particular concern in manufacturing circles. The achievements in the field to date are described in this book, which, together with its five companion volumes in the series, will provide a building block for the future development of animal cell biotechnology.
目次
R.E. Spier and J.B Griffiths, Introduction to Volume 6: Animal Cell Biotechnology Comes of Age.
T.W. Rademacher, Monitoring and Control of Glycosylation.
D. Stephens, S. Kulkarni, and B. Austen, Assembly of Membrane Proteins and their Movement to the Cell Surface.
L.-J. Eales, Measurement of Cell Surface Area.
M. Raes, Cell-Matrix Interactions.
K.E. Nye, Signalling in the Activation of Immunologically Relevant Cells.
R.H. Burdon, Oxidative Stress in Cultured Animal Cells.
P.D. Darbre, The Actions of Steroid Hormones on Animal Cells in Culture: Mechanisms and Applications.
J.R.E. Davis and N. Hoggard, Mechanisms of Action of Non-steroid Hormones in Animal Cells: Events in theNucleus.
F. Ruiz-Larrea and C.P. Berrie, Molecular Mechanisms of Cell Growth and Oncogene Action.
M.L. Wolf and M.D. Hirschel, Growing TIL and LAK Cells in Hollow Fibre Bioreactors.
W.J. Harris, Humanizing Monoclonal Antibodies for in Vivo Use.
R.J. Long, The Production and Regulation of Veterinary Virus Vaccines.
M. Mackett, Vaccinia Virus Recombinants: Expression Vectors and Potential Vaccines.
References.
Subject Index.
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