Monoclonal antibodies against bacteria

著者

• Macario, Alberto J. L.
• Conway de Macario, Everly

書誌事項

Monoclonal antibodies against bacteria

edited by Alberto J.L. Macario, Everly Conway de Macario

Academic Press, 1985-

• v. 1
• v. 2
• v. 3

注記

Includes bibliographies and indexes

内容説明・目次

巻冊次

v. 1 ISBN 9780124630017

内容説明

Monoclonal Antibodies against Bacteria, Volume I explores the generation, characterization, and utilization of monoclonal antibodies against bacteria and on other monoclonal products relevant to antibacterial immune responses. Organized into 12 chapters, this book begins with a discussion on monoclonal antibodies against bacteria, encompassing its scope, research, and directions. It shows that the coordinated use of antisera and panels of monoclonal antibodies is proving useful for classification as a diagnostic tool with prognostic implications in the case of pathogens, or as a preliminary step in taxonomy. Also, monoclonal antibodies hold great potential as instruments in working with bacteria for industrial or biotechnological purposes, including genetic engineering. This book also elucidates the use of monoclonal antibodies of predefined molecular specificity for tracing molecular ""signatures"" left by a given strain in other microorganisms, subcellular structures, and materials from ecologic niches. The possibility of antibacterial and antitoxin therapies with monoclonal antibodies is also addressed. This treatise will be a valuable reference work to anyone working with monoclonal antibodies or getting ready to prepare them against the strain(s) (or bacterial structures) of his/her interest.

目次

Contributors Preface Introduction: Monoclonal Antibodies against Bacteria for Medicine, Dentistry, Veterinary Sciences, Biotechnology, and Industry-An Overview Contents of Volume II 1 Monoclonal Antibodies against Gonococcal Pili: Uses in the Analysis of Gonococcal Immunochemistry and Virulence I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 2 Monoclonal Antibodies against Group B Streptococcus I. Introduction II. Background III. Methods and Results IV. Conclusions V. Summary References 3 Studies with Monoclonal Antibodies to Mycobacteria I. Introduction II. Results and Discussion III. Conclusions and Prospects for the Future IV. Summary References 4 Monoclonal Antibodies to Characterize the Antigenic Heterogeneity of Bacteroides intermedius I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 5 Monoclonal Antibodies against Legionella pneumophila Serogroup 1 Antigens: Characterization and Their Potential Applications I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 6 Monoclonal Antibodies Specific for the O-Antigen of Shigella flexneri and Shigella sonnei: Immunochemical Characterization and Clinical Usefulness I. Introduction II. Background III. Results and Discussion IV. Conclusions and Prospects for the Future V. Summary References 7 Monoclonal Antibodies against Group- and Type-Specific Antigens of Vibrio cholerae O:1 I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 8 Monoclonal Antibodies against Tetanus Toxin and Tetanus Toxoid I. Introduction II. Background III. Methods for Generation of Monoclonal Antibodies IV. Results and Discussion V. Prospects for the Future VI. Summary References 9 Human Monoclonal Antibodies for Prophylaxis and Therapy of Bacterial Infections I. Introduction II. Background III. Results and Discussion IV. Conclusions and Future Prospects V. Summary References 10 Monoclonal T Cells and T-Cell Hybridomas with Antibacterial Activity I. Introduction II. Background III. Results and Discussion IV. Conclusions and Prospects for the Future V. Summary References 11 A Preview of the Uses of Monoclonal Antibodies against Methanogens in Fermentation Biotechnology: Significance for Public Health I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 12 An International Hybridoma Data Bank: Aims, Structure, Function I. Introduction II. Background of Sponsoring Organizations III. Operations Framework IV. System Design V. Funding and Support VI. Prospects for the Future VII. Conclusions VIII. Summary References Index

巻冊次

v. 2 ISBN 9780124630024

内容説明

Monoclonal Antibodies Against Bacteria, Volume II provides the basis for understanding new developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume starts with the analysis of streptococcal antigens implicated in the causation of rheumatic fever and heart disease to find ways of inducing protective immunity. The next chapters deal with the detection of staphylococcal enterotoxins in foods and treatment of staphylococcal food poisoning, the classification of meningococcal isolates associated with meningitis and related disorders, and the immunology of brucellosis with emphasis on the problem of distinguishing antibrucella antibodies elicited by vaccination of cattle from antibodies elicited by infection. These topics are followed by discussions of the diagnostic and epidemiologic studies of legionellosis; the identification of antigens in gram-negative bacteria; and the development of means to study and control infections by Pseudomonas in cystic fibrosis and other pathologic conditions. Other chapters explore the analysis of toxigenicity and neutralization of botulinum toxin, the pathogenetic role of Escherichia coli's pili, and study of its antigens to understand regulatory networks of the immune system involving antiidiotypic antibodies. The remaining chapters consider the elucidation of antigenic mosaics of archaebacteria and identification of their molecular signatures in their ecological niches and other life forms. These chapters also look into the combination of bacterial genetics with hybridoma technology for elucidating structure-function relationships in membrane molecules, as well as the strategies, methods, quality control, and other practical aspects connected with industrial production of monoclonal antibodies against bacteria. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

目次

Contributors Preface Contents of Volume I 1 Structure-Function Analysis of Group A Streptococcal M Proteins with Hybridoma Antibodies I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 2 Monoclonal Antibodies to the Enterotoxins and to the Toxic Shock Syndrome Toxin Produced by Staphylococcus aureus I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Future Research VI. Summary References 3 The Use of Monoclonal Antibodies for Detecting and Serotyping Neisseria meningitidis I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 4 Development of Monoclonal Antibodies to Brucella Cell Surface Antigens I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 5 Monoclonal Antibodies to Legionella pneumophila: Possible Applications in Clinical Diagnostic Tests and Epidemiologic Investigations I. Introduction II. Background III. Results and Discussion IV. Conclusions and Prospects for the Future V. Summary References 6 Use of Monoclonal Antibodies in the Study of Common Antigens of Gram-Negative Bacteria I. Introduction II. Background III. Results and Discussion IV. Conclusions and Prospects V. Summary References 7 Application of Monoclonal Antibodies to the Study of the Surface Antigens in Pseudomonas aeruginosa I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 8 Analysis of Antigenic Structure of Clostridium botulinum Type C1 and D Toxins by Monoclonal Antibodies I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 9 Escherichia coli Capsules and Pili: Serological, Functional, Protective, and Immunoregulatory Studies with Monoclonal Antibodies I. Introduction II. Background III. Results and Discussion IV. Conclusions and Prospects for the Future V. Summary References 10 Monoclonal Antibodies of Predefined Molecular Specificity for Identification and Classification of Methanogens and for Probing Their Ecologic Niches I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References 11 Monoclonal Antibodies and the Structure of Bacterial Membrane Proteins I. Introduction II. Results and Discussion III. Conclusions and Prospects for the Future IV. Summary References 12 Industrial Applications of Monoclonal Antibodies Against Bacteria I. Introduction II. Background III. Commercial Application of Monoclonal Antibody IV. Product Design V. Regulatory VI. Summary References Index

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詳細情報

• NII書誌ID(NCID): BA00293729
• ISBN:
  • 0124630014
  • 0124630022
  • 0124630030
• LCCN: 84024455
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Orlando
• ページ数/冊数: v.
• 大きさ: 24 cm
• 分類:
  • LCC : QR186.6.B33
  • DC19 : 616.9/20793
• 件名:
  • LCSH : Bacterial antigens -- Analysis -- Collected works
  • LCSH : Antibodies, Monoclonal -- Collected works
  • MESH : Antibodies, Monoclonal
  • MESH : Bacteria