Neuroendocrine perspectives
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書誌事項
Neuroendocrine perspectives
Elsevier, 1982, c1986
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- v.8:us
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注記
Includes bibliographies and indexes
vol. 5:Proceedings of the Second Meeting of the European Neuroendocrine Association on Hypophysiotropic peptides in Basis and Clinical Neuroendocrinology held in Milano (Italy) on Octover 15-17, 1985
v.6-:Published by Springer-Verlag
内容説明・目次
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v.6:us ISBN 9780387966366
内容説明
In the first section of this volume, we have attempted to bring together some of the papers that reflect exciting new areas of development in relation to neuroendocrine investigation. Very recently, specific nucleotide recognition sequences for thyroid hormones, steroid hormones and the fundamental intracellular regulator, cyclic AMP, have been determined. In this section, the preliminary characterization and investigation of the nuclear binding proteins that mediate the actions of cAMP are described. Not only does this represent an important advance in cell biology, but it may represent a further level of alteration in control in normal and disease states. Intercellular pituitary "cross talk" is well described in the in vitro setting. The active molecules are clearly It is now important able to exert significant actions at the subnanomolar level. to design experiments in order to define the precise physiological relevance of these novel and potentially important observations. Paracrine and autocrine cellular interactions are of established importance in growth control in a variety of body tissues.
But it is only very recently that the investigation of normal and abnormal anterior pituitary growth has reached the forefront of neuroendocrine research. This is perhaps surprising, beause the inhibitory effects of doapmine agonism on lactotroph growth and differentiation have been appreciated for some time. The anterior pituitary gland produces numerous growth factors that exert a variety of functional effects on pituitary hormone synthesis and release.
目次
A. Developing Areas of Neuroendocrine Research.- Regulation of Expression of the Human Pre-ProVTP Gene.- Paracrine Interactions in the Anterior Pituitary.- Pituitary Growth Factors.- Mechanisms of Action of Growth Factors.- Neuropeptides and Neurotransmitters: Inositol Phospholipid and cAMP Responses in Cultured Brain Cells.- Brain Hormones and the Immune System.- Neuroendocrine Aspects of Cardiovascular Control: The Brain Renin-Angiotensin System.- Control of Fluid Balance.- Endogenous Na+, K+-ATPase Inhibitors.- Neuromedin U: A Novel Brain-Gut Peptide.- B. The Control of Gonadotropin Secretion.- Regulation of Gonadotropin Secretion: A 1987 Perspective.- Opioid Peptides Inhibit the Noradrenergic Input to the Rostral Hypothalamus to Reduce LH Secretion in Fasted Rats.- Attenuation of the Inhibitory Action of Corticotropin-Releasing Hormone on Luteinizing Hormone Secretion After Chronic Opioid Receptor Occupation.- A Spectrum of Disorders of LH Pulsatility in Underweight Women with Multifollicular Ovaries.- Changes in Prolactin and Proopiomelanocortin Messenger RNA in Rat Pituitary as Shown by in Situ Hybridization.- Evidence Against D2 Dopaminergic Influence on Phosphoinositide Metabolism in Pituitary and Neural Cells.- "Cured" Prolactinoma Patients After Transsphenoidal Adenomectomy: Prediction of Recurrence.- Altered Dopaminergic Control of Thyrotropin Secretion in Patients with Idiopathic Central Hypothyroidism.- C. Growth Hormone Neuroregulation.- Levels of Neuroendocrine and Pharmacologic Regulation of Growth Hormone Secretion.- Intracellular Mechanisms in GH Control.- ?1 Adrenergic Stimulation of Cytosolic Ca2+ Concentration and Growth Hormone (GH) in Rat Somatotrophs.- L-Dopa Releases GH via a GRF-dependent Mechanism in Normal Human Subjects, Whereas Arginine, Clonidine and Adrenalin Plus Propranolol Do Not.- Direct Growth Inhibitory Action of Sandostatin on Rat Pituitary 7315b Tumor Cells in Vitro.- Human Pituitary Tumors in Cell Culture: Modulation of Prolactin and Growth Hormone Messenger RNA Levels in Vitro.- Influence of Chronic Depolarization on Synthesis and the Relative Amounts of Different Forms of Somatostatin in Cultured Fetal Cerebrocortical Cells.- D. The Control and Function of the Opiate Pathways.- A Survey of the Functional Anatomy of Opiate Pathways Relating to the Hypothalamus.- Post-translational Processing of POMC in Brain and Pituitary.- Dopaminergic Agents Have Differential Effects on Both Content and Processing of ?-N-acetylated Endorphin in the Ovine Pituitary Intermediate Lobe.- Dopaminergic Modulation of Pituitary ?-N-Acetyl-transferase Activity and Adrenarche.- LHRH Priming of CRF-stimulated ACTH Output in Vitro: A Possible Paracrine Effect?.- Secretion of CRF-41, AVP and SREF by Fetal Hypothalamic Neurons Cultured in Defined Medium.- The Effects of Endogenous Catecholamines on the Hypothalamo-Pituitary Adrenal Axis in Man.- Acute and Long-term Suppression of Stress-induced ACTH Secretion by a Rat Monoclonal Antibody to Corticotropin Releasing Factor.- Diagnostic Dilemmas in Hypercortisolism: Investigation and Management.- Dual Control of ACTH Secretion by Hypothalamic and Placental Corticotropin-Releasing Factor (CRF) in Late Pregnancy.- E. Growth Hormone Neuroregulahon.- The Therapeutic Modulation of Growth Hormone Release.- F. The Future of Neuroendocrine Research.- The Future of Neuroendocrine Research: A Realistic Appraisal.- Author index.
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v.7:us ISBN 9780387968285
内容説明
Neuroendocrine Perspectives, Volume 7, is part of an international book series designed to keep clinicians and researchers appraised of important trends and new data in basic and clinical neuroendocrinology. It focuses on four very rapidly evolving major topics: - the role of dopaminergic regulation of the intermediate pituitary lobe in elucidating intracellular signal transaction pathways and other regulatory mechanisms involved in transsynaptic regulation of peptide biosynthesis, post-translational processing, and hormone secretion; - the physiological and clinical implications of corticotropin releasing factor for such areas as diagnosing Cushing's syndrome, defining the hypothalamic and pituitary origins of secondary adrenal insufficiency, and distinguishing Cushing's syndrome from psychiatric states associated with hypercortisolism; - the large number of neurotrophic factors that affect CNS neurons and of neurite promoting factors that modulate neuronal performance, with emphasis on their mechanisms of action and their possible therapeutic applications to peripheral neuropathies and central diseases; - and the many factors that regulate changes in female reproductive cycles during middle age, with careful distinction between neuroendocrine and ovarian components and special attention to the possible cause-and-effect relationship within the cascade of events resulting in acyclicity and infertility.
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v.8:us ISBN 9780387973654
内容説明
Topics of special interest in current research are presented in each volume of the series Neuroendocrine Perspectives. Volume 8 has five major sections that address new findings in our knowledge of the CNS neurotransmitter and neuropeptide systems. They broaden the traditional view of the hypothalamo-pituitary control and of the modulation of brain function by target hormones.
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v:9:us ISBN 9780387975245
内容説明
This issue of Neuroendocrine Perspectives, Volume 9, begins with a fascinating aspect of neurobiology: the steroid control of vertebrate behavior, in this case aggressive behavior. In the first chapter, Schlinger and Callard, after an extensive historical perspective of the behavioral effects of steroid hormones, review results of their own and others' laboratories on the hormonal basis of individual and sex-related differences in the intensity ofaggressive displays in birds. These studies provide evidence that brain aromatase exerts considerable control over both sex-dependent and individual differences in aggressive behavior by controllingestrogenreceptoroccupancyinsteroid-sensitivebrainregions. A greatdeal ofattention has been devoted to psychological, socio economic and cultural factors as potential causes of drug abuse and dependence, whereas the information on the neurobiologic effects of drugs of abuse is rather scanty. Wand and Froehlich address this topic in an exhaustive chapter on the effects of ethanol on the release, synthesis and posttranslational processing of hypothalamo-hypophyseal hormones. In addition, in keeping with neurophysiological and epidemiological evidence of a genetic susceptibility to alcohol addiction, they present data to indicate how the neuroendocrine system may function as a marker for genetic susceptibility to ethanol addition."
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v.8:gw ISBN 9783540973652
内容説明
Topics of special interest in current research are presented in each volume of the series "Neuroendocrine Perspectives". Volume 8 has five major sections that address new findings in our knowledge of the CNS neurotransmitter and neuropeptide systems. They broaden the traditional view of the hypothalamo-pituitary control and of the modulation of brain function by target hormones.
目次
- Prolactin releasing and inhibiting factors in the posterior pituitary
- effects of prolactin on target cells
- cellular and molecular aspects of the neuroendocrine-immune dialogue in T-cell differentiation
- the hippocampus - a site for modulatory interactions between steroid hormones, meurotransmitters and neuropeptides
- gastrointestinal peptide binding and function in the brain - emphasis on peptide YY.
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v.9:gw ISBN 9783540975243
内容説明
This volume presents five new studies in the field of neuroendocrine medicine which have implications for clinical research in neuroscience and immunology. The first study provides evidence that brain aromatase exerts considerable control over aggressive behaviour in vertebrates. The second discusses how the neuroendocrine system may function as a marker for genetic susceptibility to ethanol addiction. The third examines a new vascular endothelial growth factor that may facilitate tumour growth and metastasis. The fourth study investigates the molecular basis of neuroendocrine immunology and what processing mechanisms the CNS, endocrine and immune systems have in common. The text concludes with a discussion of the possible function of prolactin receptors in the immune and central nervous systems.
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