A genetic switch : gene control and phage λ [i.e. lambda]

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Bibliographic Information

A genetic switch : gene control and phage λ [i.e. lambda]

by Mark Ptashne

Cell Press & Blackwell Scientific Publications, 1987, c1986

Available at  / 23 libraries

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Includes index

Description and Table of Contents

Description

"A Genetic Switch" is an introduction to gene function - specifically the genetic repressor. Understanding the repressor function is essential to an understanding of biochemical activity within the gene as it is fundamental to the process by which growth and development are regulated at the molecular level. The book is intended as a basic introduction to repressor function for both advanced and undergraduate and graduate level courses in genetics and biochemistry. It will also be essential reading for researchers and students of phage, viral and general genetics.

Table of Contents

  • Part 1 The master elements of control: components of the switch
  • the action of repressor and cro
  • induction - flipping the switch
  • cooperativity - switch stability and sensitivity
  • the effect of autoregulation
  • other cases. Part 2 Protein-DNA interactions and gene control : the operator
  • repressor
  • cro
  • amino acid-base pair interactions
  • the promoter
  • gene control. Part 3 Control circuits - setting the switch : a brief overview of growth
  • control of transcription
  • the decision
  • control of integration and excision
  • other phages
  • the SOS response
  • pathways and cell development. Part 4 How do we know - the key experiments : the repressor idea
  • the repressor problem in the early 1960s
  • repressor isolation and DNA-binding
  • making more repressor
  • the claims of chapters one and two
  • Appendixes.

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