Advances in cancer research

Author(s)

• Klein, George
• Weinhouse, Sidney
• Vande Woude, George F.
• Tew, Kenneth D.
• Fisher, Paul B.

Bibliographic Information

Advances in cancer research

edited by George Klein and Sidney Weinhouse

Academic Press, 1982-

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Note

Vol. 52-111 edited by George F. Vande Woude, George Klein

Vol. 112- edited by Kenneth D.Tew, Paul B. Fisher

Vol. 73. Cumulative subject index, volumes 50-72

vol. 1-35 は別書誌 <BA2310193X>

子書誌あり

Publisher Vol. 89- : Elsevier Academic Press

Description and Table of Contents

Volume

v. 56 ISBN 9780120066568

Description

Intended for basic and clinical researchers, immunologists, virologists and molecular biologists, this book is part of a series which presents critical overviews on selected aspects of both cancer research and the basic underlying sciences.

Table of Contents

• Control of c-myc regulation in formal and neoplastic cells, C.A.Spencer and M.Groudine
• T-cell receptors - adhesion and signalling, B.E.Bierer and S.J.Burakoff
• localizing the genes for ataxia-telangiectasia - a human model for inherited cancer susceptibility, R.A.Gatti
• in site carcinoma-associated immunogenicity - therapeutic and prophylactic implications in breast cancer patients, M.M.Black and R.E.Zachrau
• transforming activity of bovine and human papillomaviruses in cultured cells, D.DiMaio
• analysis of cancer incidence data on the basis of multistage and clonal growth models, W.D.Stein
• mouse retrotransposons - a cellular reservoir of long terminal repeat (LTR) elements with diverse transcriptional specificities, E.Keshet et al
• chemistry and biology of a -Fetoprotein, H.F.Deutsch
• autocrine regulation of normal and malignant B lymphocytes, J.Gordon and J.A.Cairns
• transformation by herpesvirus saimiri, J.J.Trimble and R.C.Desrosiers.

Volume

v. 57 ISBN 9780120066575

Description

This volume in a cancer research series is concerned with oncogenes and tumour suppressor genes and their transcriptional, mitogenic and signal transducing activities as well as with major viral and immunological aspects of cancer.

Table of Contents

• myc-Family oncogenes in the development of normal and neoplastic cells, R.A. DePinho, et al
• transcriptional and transforming activities of the adenovirus E1A proteins, T. Schenk and J. Flint mitogenic action of (Lyso)-phosphatidic acid, W.H. Moolenaar
• expression and interaction of the SRC family tyrosine protein kinases in T lymphocytes, J.B. Bolen, et al
• implication the bcr/abl gene in the pathogenesis of Philadelphia chromosome-positive human leukemia, G.Q. Daley and Y. Ben-Neriah
• oncoprotein kinases in Mitosis, D. Shalloway and S. Shenoy
• current status of the BCR gene and its involvement with human leukemia, M.L. Campbell and R.B. Arlinghaus
• p53 and human malignancies, V. Rotter and M. Prokocimer
• directed plasminogen activation of the surface of normal and malignant cells, J. Pollanen, et al
• Epstein Barr virus associated lymphoproliferative disorders in immunocompromised individuals, J.A. Thomas, et al
• ADF, a growth-promoting factor derived from adult T-cell leukemia and homologous to thioredoxin - involvement in lymphocyte immortalization by HTLV-1 and EBV, J. Yodoi and T. Tursz
• the hunt for endogenous growth inhibitor and/or tumour suppressing factors - their role in physiological and pathological growth regulation, O.H. Iversen.

Volume

v. 58 ISBN 9780120066582

Description

Part of a serial which presents comprehensive reviews on advances in the broad field of cancer research. This volume covers all aspects of the molecular basis of human cancer, discussing such topics as viral interaction with lymphocytes; tumour oncogenesis, rejection and eradication.

Volume

v. 59 ISBN 9780120066599

Description

This latest volume of the biannual serial continues rapid, current coverage of all aspects of the molecular basis of human cancer, functions of oncogenes, and research strategies for cancer drug development and treatment. New topics reviewed in Volume 59 include viral hepatitis, MHC interactions, three important oncogenes and immunotherapeutic efforts.

Volume

v. 60 ISBN 9780120066605

Description

Discusses fibroblast and tyrosine kinase growth factor receptors; molecular genetic characteristics of soft tissue tumours and tumour progression; human multidrug resistance gene; oncogene activation and major histocompatibility gene expression.

Table of Contents

• Structural and functional diversity in the FGF receptor multigene family, D.E. Johnson and L.T. Williams
• protein tyrosine kinase growth factor receptors and their ligands in development, differentiation, and cancer, A.F. Wilks
• the molecular and genetic characterization of human soft tissue tumours, C.S. Cooper
• genomic instability and tumour progression - mechanistic considerations, K.C. Cheng and L.A. Loeb
• function and regulation of the human multidrug resistance gene, I.-V. Chin, et al
• relationship between MYC oncogene activation and MHC class I expression, P.I. Schrier and L.T.C. Peltenburg
• immunosuppressive factors in human cancer, D. Sulitzeanu
• lysosomes, lysosomal enzymes, and cancer, M.J. Boyer and I.F. Tannock.

Volume

v. 61 ISBN 9780120066612

Description

Volume 61 of "Advances in Cancer Research" includes coverage of the following: molecular approaches to cancer therapy, radiation resistance, cancer prevention research trials, mammalian gene amplification, retinoblastoma gene function, molecular genetic basis of breast cancer, and tumour promotion by okadaic acid class compounds.

Table of Contents

• P. Greenwald, W.F Malone, ME. Cerny, and H.R. Stern, Cancer Prevention Research Trials. M.J van de Vyver, Molecular Genetic Changes in Human Breast Cancer. M.A. Israel, Molecular Approaches to Cancer Therapy. G.R. Stark
• Regulation and Mechanism of Mammalian Gene Amplification. E. Zacksenhaus, R. Bremner, Z. Jiang, R.M. Gill, M. Muncaster, M. Sopta, R.A. Phillips, and B.L. Gallie, Unravelling the Function of the Retinoblastoma Gene. H. Fujiki and M. Suganuma, Tumour Promotion by Inhibitors of Protein Phosphatases I and 2A, the Okadaic Acid Class of Compounds. U. Kasid, K Pirollo, A. Dritschilo, and E. Chang, Oncogenic Basis of Radiation Resistance.

Volume

v. 62 ISBN 9780120066629

Description

This latest volume of the biannual serial continues rapid, current coverage of all aspects of the molecular basis of human cancer, functions of oncogenes, and research strategies for cancer drug development and treatment. Topics reviewed in Volume 62 include chromosomes and cancer; pathways in Ras function; APC gene in human cancer; molecular cytogenetics of renal cell tumors; reverse transformation, genome exposure, and cancer; peptide-binding heat shock proteins in endoplasmic reticulum; new developments in the Epstein-Barr virus field; direct cellular communication and humoral immune response.

Table of Contents

P.C. Nowell, Foundations in Cancer Research: Chromosomes and Cancer: The Evolution of an Idea. G.C. Prendergast and J.B. Gibbs, Pathways in Ras Function. Y. Nakamura, The Role of the APC (Adenomatous PolyposisColi) Gene in Human Cancers. G. Kovacs, Molecular Cytogenetics of Renal Cell Tumors. T.T. Puck and A. Krystosek, Reverse Transformation, Genome Exposure and Cancer. P.K. Srivastava, Peptide-Binding Heat Shock Proteins in the EndoplasmicReticulum: Role in Immune Response to Cancer and in Antigen Presentation. G. Pallesen, S.J. Hamilton-Dutoit, and X. Zhou, The Association of Epstein-Barr Virus (EBV) with T Cell Lymphoproliferations and Hodgkin's Disease: Two New Developments in the EBV Field. E.C. Snow and R.J. Noelle, The Role of Direct Cellular Communication during the Development of a Humoral Immune Response. Subject Index.

Volume

v. 63 ISBN 9780120066636

Description

This latest volume of the biannual serial continues rapid, current coverage of all aspect of the molecular basis of human cancer, functions of oncogenes , and research strategies of cancer drug development and treatment

Table of Contents

Foundations in Cancer Research: J. Klein, Alone on the Heart of the Earth: An Immunogeneticists Journey into the Past. D. Metcalf, Hemopoietic Regulators and Leukemia Development: A Personal Retrospective. Current Reviews: D.J. Robbins, E. Zhen, M. Cheng, S. Xu, D. Ebert, and M.H. Cobb, MAP Kinases ERK1 and ERK2: Pleiotropic Enzymes in a Ubiquitous Signaling Network. G. McFadden and K. Kane, How DNA Viruses Perturb Functional MHC Expression to Alter Immune Recognition. R. Grassmann, B. Fleckenstein, and R.C. Desrosiers, Viral Transformation of Human T Lymphocytes. N. Haran-Ghera, Lymphomagenesis in AKR Mice: B Cell Lymphomas as a Model of Tumor Dormancy. J.F. Rehfeld and W.W. van Solinge, The Tumour Biology of Gastrin and Cholecystokinin. Chapter References. Subject Index.

Volume

v. 64 ISBN 9780120066643

Description

This volume contains reviews highlighting some of the most important achievements in understanding the molecular basis of cancer. Included are reviews on human papilloma virus and tumor suppressor gene products, the function of SH2 and SH3 domains in tyrosine kinase signal transduction, oncogene activation in mammary tumors, the phenotypes of polyoma middle T antigen in transgenic animals, and the role of protein kinase C and FCg receptors in neoplastic disease. Transgenic animal models for the study of molecular events in cancer are especially featured in these reviews.

Table of Contents

Interactions between Papillomavirus Proteins and tumor Suppressor Gene Products, K.H. Vousden. The Retinoblastoma Tumor Suppressor Protein, J.Y.J. Wange, E.S. Knudsen, and P.J. Welch. SH2 and SH3 Domains in Signal Transduction, T. Pawson. Activation of the Src Family of Tyrosine Kinases in Mammary Tumorigenesis, S.K. Muthuswamy and W.J. Muller. Oncogenic Properties of the Middle T Antigens of Polyomaviruses, F. Kiefer, S.A. Courtneidge, and E.F. Wagner. Selective Involvement of Protein Kinase C Isozymes in Differentiation and Neoplastic Transformation, J.Goodnight, H. Mischark, and J.F. Mushinski. FCg Receptors in Malignancies: Friends of Enemies? J. Gergely and G. Sarmay. Dissecting Molecular Carcinogenesis: Development of Transgenic Mouse Models by Epidermal Gene Targeting, D.A. Greenhalgh and D.R. Roop. Index.

Volume

v. 66 ISBN 9780120066667

Description

ADVANCES IN CANCER RESEARCH is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Volume 66 contains encompassing overviews of p53 and its role in both breast cancer and in the cell cycle. Approximately 50% of all human tumors involve mutations of the p53 gene, suggesting that proper understanding of its properties and mechanisms could offer real hope for finding successful clinical therapy. Other themes presented in Volume 66 include cyclins and cyclin-dependent kinases in the cell cycle. Approximately 50% of all human tumors involve mutations of the p53 gene, suggesting that proper understanding of its properties and mechanisms could offer real hope for finding sucessful clinical therapy. Other themes presented in Volume 66 include cyclins and cyclin-dependant kinases in the cell cycle: the molecular genetics of 11q23 chromosome translocations: the possible link between the aberrant expression of Scatter Factor and c-Met with AIDS Associated kaposi's Sarcoma, the use of Radiation Leukemia Virus to induce leukemogenesis, and the Adenovirus system as a model for the insertion of foreign DNA into mammalian genomes. Also of note in the "Foundations of cancer Research" section are articles by two prominent cancer researchers recollecting the ideas and paths taken in their lifelong work. Paradigms proposed in these reviews mark thoughtful progress toward preventative therapy in oncogenesis and gene therapy of cancer. They also cast light on the fact that the ideas presented in these chapters are only the tip of the iceburg in this complex and ever evolving field, and suggest many more to come in future volumes.

Table of Contents

Foundations in Cancer Research Articles: L. Sachs, The Adventures of a Biologist: Prenatal Diagnosis, Hematopoiesis, Leukemia, Carcinogenesis, and Tumor Suppression. M. Feldman, From Aristotle, through Spemann, to Tumor Immunology: A Personal Experience. Regular Articles: M.A. Ozbun and J.S. Butel, Tumor Suppressor p53 Mutations and Breast Cancer: A Critical Analysis. G. Selivanova and K.G. Wiman, p53: A Cell Cycle Regulator Activated by DNA Damage. J. Pines, Cyclins and Cyclin-Dependent Kinases: Theme and Variations. E. Canaani, P.C. Nowell, and C.M. Croce, Molecular Genetics of 11q23 Chromosome Translocations. P.J. Polverini and B.J. Nickoloff, Role of Scatter Factor and the c-Met Protooncogene in the Pathogenesis of AIDS-Associated Kaposis Sarcoma. S. Miyamoto and I.M. Verma, REL/NF-(B/1(B Story. E. Yefenof and M. Kotler, Radiation Leukemia Virus-Induced Leukemogenesis: A Paradigm of Preleukemia and Its Control by Preventive Therapy. W. Doerfler, The Insertion of Foreign DNA into Mammalian Genomes and Its Consequences: A Concept in Oncogenesis. References. Subject Index.

Volume

v. 67 ISBN 9780120066674

Description

Advances in Cancer Research is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Topics covered in Volume 67 include a developmental model of progenitor cell oncogenesis based on a description of transcriptional control; pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples; the genetics of murine lung tumors; the molecular pathogenesis of AIDS-related lymphomas; HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development; a summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis. There are two reviews discussing angiogenesis: the first focuses on the role of scatter factor and the second, the VEGF-FH receptor system. The "Foundations in Cancer Research" article by Alfred G. Knudson is a personal account of his career studying mutation and cancer.

Table of Contents

Foundations in Cancer Research Article: A.G. Knudson, Jr., Mutation and Cancer: A Personal Odyssey. Regular Articles: A.T. Look, Oncogenic Role of "Master" Transcription Factors in Human Leukemias and Sarcomas: A Developmental Model. B. Dutrillaux, Pathways of Chromosome Alteration in Human Epithelial Cancers. T.A. Dragani, G. Manenti, and M.A. Pierotti, Genetics of Murine Lung Tumors. G. Gaidano and R. Dalla-Favera, Molecular Pathogenesis of AIDS-Related Lymphomas. F. Garrido, T. Cabrera, M.A. Lopez-Nevot, and F. Ruiz-Cabello, HLA Class I Antigens in Human Tumors. J.W. Gratama and I. Ernberg, Molecular Epidemiology of Epstein-Barr Virus Infection. E.M. Rosen and I.D. Goldberg, Scatter Factor and Angiogenesis. M. Shibuya, A Review on the Role of VEGF-Flt Receptor System in Normal and Tumor Angiogenesis. References. Subject Index.

Volume

v. 68 ISBN 9780120066681

Description

Volume 68 of Advances in Cancer Research continues the tradition of publishing up-to-date reviews and "hot" topics in cancer research. This volume begins with a "Foundations in Cancer Research" article by Harald zur Hausen that reviews his years of research on the idea that cancer can be triggered by infection. The structure and function of the cytokine receptor superfamily and its association with leukemias are discussed in depth by James Ihle. Marcia Hall and Gordon Peters review the evidence indicating that genetic abnormalities hinder the function of certain cyclins and their inhibitors. The most widely studied protooncogene, c-myc, is reviewed by Marie Henriksson and Bernhard Luscher; the chapter focuses on the function of c-myc as a transcription factor rather than on the effects of gene translocation and activation on malignancies. Ham Werner and Derek LeRoith present data on the role that insulin-like growth factors play on cell growth and regulation. In the final chapter, Olli-P. Kallioniemi and Tapio Visakorpi investigate the field of prostate cancer and, more importantly, the biological reason and natural history behind the growth of this cancer.

Table of Contents

Foundations in Cancer Research: H. zur Hausen, Viruses in Human Tumors--Reminiscences and Perspectives: Epstein-Barr Virus DNA in Burkitt's Lymphomas and Nasopharyngeal Cancers. Papillomavirus Etiologyof Cancer of the Cervix. Papillomaviruses in Nonanogenital Cancers. Viruses as Tumor Initiators--Their Role as Inducers of Specific DNA Amplifications and as Mutagens. The Search for Other Tumorviruses. References. J.N. Ihle, Signaling by the Cytokine Receptor Superfamily in Normal and Transformed Hematopoietic Cells: Introduction. Structure of the Cytokine Receptor Superfamily. Leukemic Transformation by Structurally Altered Cytokine Receptors. Tyrosine Phosphorylation in Cytokine Receptor Function. Cytoplasmic Tyrosine Kinases Implicated in Specific Cytokine Responses. Janus, Kinases: A Unique Family of Cytoplasmic Protein Tyrosine Kinases: Association of Jaks with Cytokine Receptors and Activation Following Ligand Binding. Activation of ras Signaling Pathway by Cytokine Receptors. Cytokine-Induced Increases in Phosphatidylinositol (PI) 3-Kinase Activity. Cytokine-Induced Tyrosine Phosphorylation of Vav. Hematopoietic Cell Phosphatase: A Negative Growth Regulator. Syp Tyrosine Phosphatase: A Positive Growth Regulator. IRS-1 and 4PS: Signal Transducers Phosphorylated in Response to Cytokines. Stats: A Novel Family of Transcription Factors Identified in Interferon Signaling. Stats: A Common Theme in Cytokine Signaling. Mechanisms of Stat Recruitment to Cytokine Receptor Complexes. Concluding Remarks. References. M. Hall and G. Peters, Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer: Introduction. The Cell Cycle and Cancer. Chromosomal Translocations Affecting Cyclin D1. Amplification of Cyclin D1 in Human Tumors. Amplification of Cdk4 in Sarcomas and Gliomas. Deletion or Mutation of the p16/CDKN2 Gene in Primary Tumors. The Cyclin D1-p16-pRb Pathway in HumanCancer. References. M. Henriksson and B. Luscher, Myc Proteins: Essential Regulators of Cell Growth: Introduction. The myc Genes and Functional Domains of the Myc Proteins. The Myc Network. Myc Target Genes. The Role of the Myc Network Proteins in the Cell Cycle and during Differentiation. Myc-Mediated Apoptosis. Effects of Myc Network Proteins on Transformation. Future Aspects. References. H. Werner and D. LeRoith, The Role of Insulin-like Growth Factor System in Human Cancer: The Insulin-like Growth Factor (IGF) System of Ligands, Receptors, and Binding Proteins. Molecular Organization. Signal Transduction through the IGF-1 Receptor. IGFs and the Cell Cycle. Apoptosis. Role of the IGF-1 Receptor in Transformation. Role of IGF-II in Tumorigenesis. Regulation of IGF-II and IGF-1 Receptor Gene Promoters by Tumor Suppressor WT1: Implications for Wilms' Tumor. Loss of Imprinting of the IGF-II Gene: A Possible Mechanism for Tumorigenesis. IGFs as Motility Factors. Selected Examples of IGF Involvement in Human Cancer. IGF-II-Secreting Tumors and Hypoglycemia. IGF-Binding Proteins and Tumorigenesis. Therapeutics. Conclusions. References. O.-P. Kallioniemi and T. Visakorpi, Genetic Basis and Clonal Evolution of Human Prostate Cancer: Introduction. Histological and Clinical Progression of Prostate Cancer. Multistep Tumorigenesis and the Clonal Evolution of Cancer. Inherited Predisposition to Prostate Cancer. Genes and Genetic Alterations in Primary Prostate Cancer and Precursor Lesions. Genes and Genetic Alterations in Metastases. Genetic Alterations in Hormone-Refractory Prostate Cancer. Conclusions, Unanswered Questions, and Clinical Implications. References. Subject Index.

Volume

v. 69 ISBN 9780120066698

Description

This volume of Advances in Cancer Research begins with a "Foundations in Cancer Research" articles by Harold Varmus. He focuses on Andrew Lwoff who influenced a generation of scientists and how Dr. Lwoff's influence on Howard Temlin, in particular, led to the identification of the cause of AIDS. Hiroto Okayama and colleagues discuss the conserved control mechanisms of the G1 and G2 phases in fission yeasts and mammals, and the newly identified control genes. Nilis Mandahl presents the cytogenetic findings in bone and soft tissue tumors and introduces the major molecular genetic findings. Hannel Tapiovaara dn co-workers review plasmin generation at restricted areas of the cell surface and hypothesize that it may be a catalyst for tumor cells to metastasize. Noel Bouck et al. review the evidence suggesting that certain types of stimulations of inducers by activated oncogenes, and decreased production of inhibitors of angiogenesis, may be instrumental in enabling developing tumour cells to attract new cells and continue the malignant growth. Peter L. Stern reviews the role of immunity and the prospects for immune intervention in cervical neoplasia. Lastly, Denis J. Moss and his associates discuss the Epstein-Barr virus (EBV) host-virus relationship and the immune control of EBV infections and examine development of vaccines and immunotherapy.

Table of Contents

Foundations in Cancer Research: H. Varmus, The Pastorian: A Legacy of Louis Pasteur. H. Okayama, A. Nagata, S. Jinno, H. Murakami, K. Tanaka, and N. Nakashima, Cell Cycle Control in Fission Yeast and Mammals: Identification of New Regulatory Mechanisms: Introduction. Life Cycle of Fission Yeast. Cell Cycle Start Control of Fission Yeast. Cell Cycle Start Control of Mammals. Mitotic Start Control of Fission Yeast. Mitotic Start Control of Mammals. Closing Remarks. References. N. Mandahl, Cytogenetics and Molecular Genetics of Bone and Soft Tissue Tumors: Introduction. Cytogenetic and Major Molecular Genetic Findings. Aberrations Shared by Several Tumor Types. Diagnosis and Prognostication Based on Genetic Analysis. References. H. Tapiovaara, R. Alitalo, and A. Vaheri, Plasminogen Activation on Tumor Cell Surface and Its Involvement in Human Leukemia: Introduction. Components of Plasminogen Activation. Activation of Plasminogen on Cell Surface. Regulators of Plasminogen Activation. Internalization of uPA. Plasminogen Activators in Tumors. Plasminogen Activators in Cell Migration. Plasminogen Activation and Leukemia. Future Aspects. References. N. Bouck, V. Stellmach, and S. Hsu, How Tumors Become Angiogenic: Introduction. Tumor Angiogenesis. Development of an Angiogenic Phenotype. Therapeutic Strategies Targeting Tumor Angiogenesis. Conclusions. References. P.L. Stern, Immunity to Human Papillomavirus-Associated Cervical Neoplasia: Introduction. Human Papillomaviruses. Immunological Recognition of HPV in Cervical Neoplasia. Evasion of Immune Surveillance. Prospects for Immune Intervention. Conclusions. References. D.J. Moss, C. Schmidt, S. Elliott, A. Suhrbier, S. Burrows, and R. Khanna, Strategies Involved in Developing an Effective Vaccine to EBV-Associated Diseases: Introduction. Host-Virus Relationships. Humoral Response to EBV Infection. CTL Response to EBV Infection. Developing a Vaccine for EBV. Vaccines and Immunotherapy for EBV-Associated Diseases. References. Subject Index.

Volume

v. 70 ISBN 9780120066704

Description

Volume 70 begins with two "Foundations in Cancer Research" articles, a staple of the Advances in Cancer Research series. The first article by Michael Stoker presents a review of some of the early advances made by cancer cell biology researchers. The second article by Emmanuel Farber describes the methods by which researchers delineate the phenotype of cells and ways to alter these phenotypes to prevent or delay carcinomas. Chidambaram and Dean illustrate the tumors and associated malformations of nevoid basal cell carcinoma. Koli and Keski-Oja review the effects of how transforming growth factor-b regulates cell proliferation, differentiation, and morphogenesis and its regulation by the steroid hormone superfamily. Jean-Marc Lemaitre and colleagues discuss the involvement of protooncogenes in the control of the cell cycle and embryonic development with specific attention paid to c-Myc expression and c-Myc function. A review of the various studies involving tumor-infiltrating lymphocytes and their possible role in cancer prevention is presented by Steven Rosenberg and co-workers. Finally, Bruce Ponder and Darrin Smith review the genetic and biological aspects of multiple endocrine neoplasia type-2 syndromes and the phenotypes associated with ret mutations.

Table of Contents

Foundations in Cancer Research: M. Stoker, Fundamentals of Cancer Cell Biology: Introduction. Antecedents. Autobiographical Note. Foundations of Tissue Culture. Foundations of Cell Culture. Clones. The Immortals: Stable Cell Lines. The Mortals: Cell Strains. Food for Cells in Culture. Growth Factors. Short-Range Cell Interactions. Junctional Communication. Cell and Substrate Adhesion. The Tumor Viruses. Cell Fusion. Conclusion. References. E. Farber, The Step-by-Step Development of Epithelial Cancer: From Phenotype to Genotype: Cancer Development as Basic to Cancer Research. Patterns of Development of Epithelial Cancers. A Working Hypothesis. The Phenotypes. The Genotypes. The Challenge. References. A. Chidambaram and M. Dean, Genetics of the Nevoid Basal Cell Carcinoma Syndrome: Introduction. Clinicopathological Features of NBCCS. Genetics of NBCCS. Strategies for Isolation of Candidate Genes. Discussion. References. K. Koli and J. Keski-Oja, Transforming Growth Factor-( System and Its Regulation by Members of the Steroid-Thyroid Hormone Superfamily: Introduction. Transforming Growth Factor-(. Dual Effects of TGF-(on Cell Proliferation. Regulation of Cell Differentiation by TGF-(. TGF-(in the Regulation of the Immune System. The Steroid-Thyroid Hormone Superfamily. Steroid Hormone Regulation of TGF-( Isoform Expression. Regulation of Plasminogen Activation by Steroids. Summary. References. J.-M. Lemaitre, R.S. Buckle, and M. Mechali, c-Mycin the Control of Cell Proliferation and Embryonic Development: Introduction. The c-myc Gene. Structural and Functional Features of the c-Myc Protein. c-Myc as a Transcription Factor. c-Myc and Cell Proliferation. c-Myc in Embryonic Development. c-Myc and Differentiation. c-Myc and Apoptosis. References. S.A. Rosenberg, Y. Kawakami, P.F. Robbins, and R.-F. Wang, Identification of the Genes Encoding Cancer Antigens: Implications for Cancer Immunotherapy. Introduction. Methodology. Human Melanoma Antigens Recognized by T Cells. Cancer Therapies Based on the Molecular Identification of Cancer Antigens. References. B.A.J. Ponder and D. Smith, The MEN II Syndromes and the Role of the ret Proto-oncogene:. Introduction. The MEN II Syndromes. The ret Proto-oncogene. Development of the Tissues Involved in MEN II, and Patterns of ret Expression. Speculations on How Different ret Mutations Result in the Associated Phenotypes and in Tumor Formation. Other Events in Tumor Progression. Animal Models of MEN II. Clinical Implications of the Identification of ret Mutations in MEN II. Future Prospects. References. Subject Index.

Volume

v. 71 ISBN 9780120066711

Description

Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies. Kok et all. Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.

Table of Contents

S.E. Morgan and M.B. Kastan, p53 and ATM: Cell Cycle, Cell Death and Cancer. K. Kok, S.L. Naylor, and C.H.C.M. Buys, Deletion of the Short Arm of Chromosome 3 in Solid Tumors and the Search for Suppressor Genes. P. Peltomaki and A. de la Chapelle, Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer. S.L. McKenna and T.G. Cotter, Functional Aspects of Apoptosis in Hematopoiesis and Consequence of Failure. M.J Ravitz and C.E. Wenner, Cyclin Dependent Kinase Regulation during G1 Phase and Cell Cycle Regulation by TGF-B. A.J.G. Simpson, The Natural Somatic Mutation Frequency and Human Carcinogenesis. D. Naor, R.V. Sionov, and D. Ish-Shalom, CD44: Structure, Function, and Association with the Malignant Process. L.L. Villa, Human Papillomaviruses and Cervical Cancer. M.L. Disis and M.A. Cheever, HER-2/neu Protein: A Target for Antigen Specific Immunotherapy of Human Cancer. References. Subject Index.

Volume

v. 72 ISBN 9780120066728

Description

The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.

Table of Contents

G. Klein, Foulds Dangerous Idea Revisited: The Multistep Development of Tumors 40 Years Later. L.A. Loeb, Cancer Cells Exhibit a Mutator Phenotype. R. Khosravi-Far, S. Campbell, K.L. Rossman, and C.J. Der, Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins. M. Saville and R. Watson, B-Myb: A Key Regulator of the Cell Cycle. S.B. Baylin, J.G. Herman, J.R. Graff, P.M. Vertino, and J.-P. Issa, Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia. S. Grant, Ara-C: Cellular and Molecular Pharmacology.

Volume

v. 73 ISBN 9780120066735

Description

Academic Press proudly presents this Cumulative Subject Index covering Volumes 50-72 of Advances in Cancer Research. In one comprehensive source, the interested reader can find references to specific articles on topics such as breast cancer, prostate cancer, Kaposi's sarcoma, Burkitt's lymphoma, leukemias, oncogenes, transcription factors, tumor genetics, p53, T-cell receptors, and drug resistance. This cumulative index will serve not only as a complete overview of the major topics published in Advances in Cancer Research, but also as an indicator of the progress made in cancer research over the last ten years.

Table of Contents

Cumulative Index, Volumes 50-72.

Volume

v. 74 ISBN 9780120066742

Description

This volume of Advances in Cancer Research begins with a review by M. Roussel of the key effectors of cytokine and growth factor signaling to the cell cycle block. P 53 and how it controls the cell cycle, genomic stability, and apoptosis are reviewed by M.R.A. Mowat. The third chapter, by T.S. Lewis and colleagues, discusses the effect of MAP kinase cascades as examples of signal transduction mechanisms in signaling pathways. In Chapter 4, Sozi et al. Review the frequent abnormalities found in the FHIT gene in a variety of cancer-derived cell lines. Volume 74 concludes with an overview by J.J. Hsuan and co-workers of the cellular functions of PtdlnsP2 and the regulation of its biosynthesis.

Table of Contents

M.F. Roussel, Key Effectors of Signal Transduction and G1 Progression. M.R.A. Mowat, p53 in Tumor Progression: Life, Death, and Everything. T.S. Lewis, P.S. Shapiro, and N.G. Ahn, Signal Transduction through MAP Kinase Cascades. G. Sozzi, K. Huebner, and C.M. Croce, FHIT in Human Cancer. J.J. Hsuan, S. Minogue, and M. dos Santos, Phosphoinositide 4- and 5-Kinases and the Cellular Roles of Phosphatidylinositol 4,5-Bisphosphate.

Volume

v. 75 ISBN 9780120066759

Description

Volume 75 of Advances in Cancer Research continues the series' goal of publishing timely and authoritative reviews in the broad field of cancer research. Graves and Petersen begin the volume with a review of ets proteins and their role in biological specificity. Chapter 2 by Boshoff and Weiss discusses Kaposi's sarcoma and its associated herpesviruses. Chapter 3 by Taipale and colleagues discusses the ways in which the effects of TGF-B can be targeted through its deposition to the extracellular matrix in a latent form. Petersen and colleagues present their research on breast cancer from the phenotypic differentiation standpoint in Chapter 4. The clinical, pathological, and genetic characteristics of hereditary renal carcinoma are reviewed by Zbar and Lerman in Chapter 5. In Chapter 6, Ellem and co-workers discuss the numerous ways in which metastatic cells escape immune killing. Chapter 7 by Kramer et al. Concludes the volume with a discussion on the role of apoptosis via CD95 in liver, colon, and hematopoetic cells.

Table of Contents

B.J. Graves and J.M. Peterson, Specificity within the ets Family of Transcription Factors. C. Boschoff and R.A. Weiss, Kaposi's Sarcoma - Associated Herpesvirus. J. Taipale, J. Saharinen, and J. Keski-Oja, Extracellular Matrix Associated Transforming Growth Factor-b: Role in Cancer Cell Growth and Invasion. O.W. Petersen, L. Ronnov-Jessen, V.M. Weaver, and M.J. Bissell, Differentiation and Cancer in the Mammary Gland: Shedding Light on an Old Dichotomy. B. Zbar and M. Lerman, Inherited Carcinomas of the Kidney. K.A.O. Ellem, C.W. Schmidt, M.G.E. O'Rourke, C-L. Li, G. Sing, G. Macdonald, I. Misko, and A. Kelso, The Labyrinthine Ways of Cancer Immunotherapy - T Cell, Tumour Cell Encounter "How Do I Lose Thee? Let Me Count the Ways." P.H. Krammer, P.R. Galle, P. Moeller, and K.-M. Debatin, CD95 (APO-1/FAS)-Mediated Apoptosis in Normal and Malignant Liver-, Colon-, and Hematopoietic Cells. Subject Index.

Volume

v. 76 ISBN 9780120066766

Description

Volume 76 of Advances in Cancer Research continues the series' goal of publishing timely and authoritative reviews in the broad field of cancer research. Ruoslahti begins the volume with a review of fibronectin and its integrin receptors in cancer. Chapter 2 by Ganter and Lipsick discusses Myb and oncogenesis. Biscardi and colleagues present their research on c-Src, receptor tyrosine kinases, and human cancer in Chapter 3. Chapter 4 by Schulz covers epidemiology of Kaposi's sarcoma and associated herpesvirus/human herpesvirus 8. The consensus on synergism between cigarette smoke and other environmental carcinogens in the causation of lung cancer is reviewed by Reif and Heeren in Chapter 5. In Chapter 6, Breivik and Gaudernack discuss perspectives on carcinogenesis and natural selection in the genetics and epigenetics of colorectal cancer. Chapter 7 by Coulie and co-workers concludes the volume with a discussion of anti-tumor immunity at work in a melanoma patient.

Table of Contents

E. Ruoslahti, Fibronectin and Its Integrin Receptors in Cancer. B. Ganter and J.S. Lipsick, Myb and Oncogenesis. J.S. Biscardi, D.A. Tice, and S.J. Parsons, C-Src, Receptor Tyrosine Kinases, and Human Cancer. T.F. Schulz, Epidemiology of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8. A.E. Reif and T. Heeren, Consensus on Synergism Between Cigarette Smoke and Other Environmental Carcinogens in the Causation of Lung Cancer. J. Breivik and G. Gaudernack, Carcinogenesis and Natural Selection: A New Perspective to the Genetics and Epigenetics of Colorectal Cancer. P.G. Coulie, H. Ikeda, J.-F. Baurain, and R. Chiari, Anti-Tumor Immunity at Work in a Melanoma Patient. Subject Index.

Volume

v. 77 ISBN 9780120066773

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.

Table of Contents

• N. Barker, P.J. Morin, and H. Clevers, The Yin-Yang of TCF/ -Catenin Signalling. L.N. Klapper, M.H. Kirschbaum, M. Sela, and Y. Yarden, Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors. P. Hainaut and M. Hollstein, p53 and Human Cancer: The First Ten Thousand Mutations. E.J. Leonard and A. Danilkovitch, Macrophage Stimulating Protein. V.J.M. Wielenga, R. van der Neut, G.J.A. Offerhaus, and S.T. Pals, CD44 Glycoproteins in Colorectal Cancer
• Expression, Function, and Prognastic Value. N. Janin, A Simple Model For Carinogenesis of Colorectal Cancer with Microsatellite Instability.

Volume

v. 78 ISBN 9780120066780

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.

Table of Contents

W. Zwerschke and P. Jansen-Durr, Cell Transformation by the E7 Oncoprotein of HPV Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins. A. Wells, Tumor Invasion: Role of Growth Factor-Induced Cell Motility. P. Mignatti and D.B. Rifkin, Non-Enzymatic Interactions Between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology. K. Murakami-Mori, S. Mori, and B. Bonavida, Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis. G.J. Kelloff, Perspectives on Cancer Chemoprevention Research and Drug Development.

Volume

v. 79 ISBN 9780120066797

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.

Volume

v. 80 ISBN 9780120066803

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented on a variety of topics including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.

Volume

v. 81 ISBN 9780120066810

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells.

Volume

v. 82 ISBN 9780120066827

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papilloma viruses, and modeling prostate cancer in the mouse.

Volume

v. 83 ISBN 9780120066834

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including suppressor and oncogenic roles of TGF-b and its signaling pathways in tumorigenesis, hereditary diffuse gastric disease, the role of heparan sulfate proteoglycans in cell signaling and cancer, V-gene mutations in B-cell-derived human malignancy, MHC antigens and tumor escape from immune surveillance, the role of selection in progressive neoplastic transformation, and the genomic stability, neuronal development, and cancer cross paths of ATM.

Volume

v. 84 ISBN 9780120066841

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including gene expression in inherited breast cancer, multiparameter analyses of cell cycle regulation in tumorigenesis, Rho GTPases in transformation and metastasis, the myc oncogene, genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes, treatment of Epstein-Barr virus-associated malignancies with specific T cells, the role of glycogen synthase kinase-3 in cancer, chronic immune activation and inflammation in the pathogenesis of AIDS and cancer, and molecular biology of Hodgkin's lymphoma.

Volume

v. 85 ISBN 9780120066858

Table of Contents

The Von Hippel-Lindau Tumor Suppressor Complex and Regulation of Hypoxia-Inducible Transcription. Retinoblastoma Tumor Suppressor and Genome Stability. The Abl Family Kinases: Mechanisms of Regulation and Signaling. Cellular Immunity to the Her-2/neu Proto-oncogene. A New Challenge for Successful Immunotherapy by Tumors That Are Resistant to Apoptosis: Two Complementary Signals to Overcome Cross-Resistance. Cell Volume and Ion Changes During Apoptotic Cell Death. Mitochondria and Apoptosis: New Therapeutic Targets.

Volume

v. 86 ISBN 9780120066865

Table of Contents

Coordinate Regulation of Translation by the PI 3-Kinase and mTOR Pathways. Histone Acetyl-Transferases and Deacetylases in the Control of Cell Proliferation and Differentiation. Molecular Pathogenesis of Human Hepatocellular Carcinoma. The Cell Mediated Immune Response to Human Papillomavirus Induced Cervical Cancer: Implications for Immunotherapy. The T-cell Response in Patients with Cancer. The Life and Death of a B Cell.

Volume

v. 87 ISBN 9780120066872

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including chromosome instability in cancer; telomerase inhibitors as an option for chemotherapy; avian retrovirus pathogenicity; Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma; immunotherapy for prostate cancer; and the role of lymphocytes in anti-tumor immunity.

Table of Contents

Chromosome Instability in Cancer: How, When and Why Telomerase Inhibitors - A New Option for Chemotherapy Variation of Especially Avian Retrovirus Pathogenicity: A Historical Background Epstein-Barr Virus and Undifferentiated Nasopharyngeal Carcinoma New Immunobiological and Molecular Insights on a Long-Standing Etiopathogenic Association Advances in Immunotherapy for Prostate Cancer The Role of Lymphocytes in Anti-Tumor Inmmunity

Volume

v. 88 ISBN 9780120066889

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including HAMLET and tumor cells; survivin and apoptosis control; retroviral insertional mutagenesis; aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis; and epigenetic variability and the evolution of human cancer.

Table of Contents

• HAMLET Kills Tumor Cells by Apoptosis - Cellular, Molecular and Therapeutic Aspects
• Survivin and Apoptosis Control
• Retroviral Insertional Mutagenesis: Tagging Cancer Pathways
• Aberrant Ubiquitin-Mediated Proteolysis of Cell Cycle Regulatory Proteins and Oncogenesis
• Epigenetic Variability and the Evolution of Human Cancer

Volume

v. 89 ISBN 9780120066896

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.

Table of Contents

Mdm2 - A Regulator of Cell Growth and Death The Systemic Progression of Human Cancer: A Focus on the Individual Disseminated Cancer Cell - The Unit of Selection Seizing of T-Cells by Human T-Cells Leukemia/Lymphoma Virus Type II Host Cell Dependent Expression of Latent Epstein-Barr Virus Genomes Regulation by DNA Methylation Gene Expression Profiling of Renal Cell Carcinoma and Its Implications in Diagnosis, Prognosis, and Therapeutics

Volume

v. 90 ISBN 9780120066902

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.

Volume

v. 91 ISBN 9780120066919

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including

Table of Contents

• Imatinib as a Paradigm Of Targeted Therapies
• Prostate Cancer and the Met Hepatocyte Growth Factor Receptor
• Keratinocyte Growth Factor (KGF/FGF7), a Homeostatic Factor with Therapeutic Potential for Epithelial Protection and Repair
• Histone Deacetylase Inhibitors
• Raf-1 Kinase Inhibitor Protein (RKIP): Structure, Function, Regulation of Cell Signaling and Pivotal Role in Apoptosis

Volume

v. 92 ISBN 9780120066926

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics.

Table of Contents

An Analysis of a Wrong Nobel Prize - Johannes Fibiger 1926: A Study in the Nobel Archives Tumor-Host Immune Interactions and Dendritic Cell Dysfunction Non-invasive Imaging of Reporter Gene Expression in Living Subjects A Role for Id Proteins in Mammary Gland Physiology and Tumorigenesis p38 MAP Kinase's Emerging Role as a Tumor Suppressor Deregulation of the Cell Cycle by Epstein-Barr Virus (EBV)

Volume

v. 93 ISBN 9780120066933

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Central Roles of Mg2+ and MgATP2- in the Regulation of Protein Synthesis and Cell Proliferation: Significance for Neoplastic Transformation; Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer; T-Cell Transformation and Oncogenesis by a2-Herpesviruses; Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis; Soluble Mediators of Inflammation During Tumor Development; Classical and Non-Classical HLA Class I Antigen and NK Cell Activating Ligand Changes in Malignant Cells: Current Challenges and Future Directions.

Table of Contents

• Central Roles of Mg2+ and MgATP2- in the Regulation of Protein Synthesis and Cell Proliferation: Significance for Neoplastic Transformation
• Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer
• T-Cell Transformation and Oncogenesis by a2-Herpesviruses
• Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis
• Soluble Mediators of Inflammation During Tumor Development
• Classical and Non-Classical HLA Class I Antigen and NK Cell Activating Ligand Changes in Malignant Cells: Current Challenges and Future Directions.

Volume

v. 94 ISBN 9780120066940

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Molecular Mechanisms in Gliomagenesis; Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting; Mitochondria as Functional Targets of Proteins Coded by Human Tumor Viruses; Apoptotic Pathways and Therapy Resistance in Human Malignancies; Endostatin Signaling and Regulation of Endothelial Cell-Matrix Interactions; Molecular Mechanisms and Clinical Development.

Table of Contents

• Molecular Mechanisms in Gliomagenesis
• Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting
• Mitochondria as Functional Targets of Proteins Coded by Human Tumor Viruses
• Apoptotic Pathways and Therapy Resistance in Human Malignancies
• Endostatin Signaling and Regulation of Endothelial Cell-Matrix Interactions
• Molecular Mechanisms and Clinical Development.

Volume

v. 95 ISBN 9780120066957

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including NY-ESO-1: review of an immunogenic tumor antigen; Order, disorder, death: lessons from a superorganism; Control of differentiation in progression of epithelial tumors; Cancer vaccines: preclinical studies and novel strategies; Clinical results of vaccine therapy for cancer: learning from history for improving the future; Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell based cancer vaccines; NK cell receptors as tools in cancer immunotherapy; Innate immune recognition and suppression of tumors; Inhibitors of the HSP90 molecular chaperone: current status.

Table of Contents

NY-ESO-1: Review of an Immunogenic Tumor Antigen. Order, Disorder, Death: Lessons from a Superorganism. Control of Differentiation in Progression of Epithelial Tumors. Cancer Vaccines: Preclinical Studies and Novel Strategies. Clinical Results of Vaccine Therapy for Cancer: Learning from History for Improving the Future. Immunodominance and Immunodomination: Critical Factors in Developing Effective CD8+ T-Cell Based Cancer Vaccines. NK Cell Receptors as Tools in Cancer Immunotherapy. Innate Immune Recognition and Suppression of Tumors. Inhibitors of the HSP90 Molecular Chaperone: Current Status.

Volume

v. 97 ISBN 9780120066971

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, "Molecular Oncology - From Bench to Bedside," held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein's combined 160th birthday. To honor this occasion, this volume brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called "Foundations in Cancer Research" was initiated and the tributes honoring the Kleins' bodies of work presented at the minisymposium are especially appropriate for the series.

Table of Contents

Opening Dedication. Structural Biology of the Tumor Suppressor p53 and Cancer-Associated Mutants. Immunotherapy by Allogeneic Stem Cell Transplantation. Mnt Takes Control as a Key Regulator of the Myc/Max/Mxd Network. Lytic Cycle Switches of Oncogenic Human Gammaherpesviruses. No Life Without Death. Control of Apoptosis in Human Multiple Myeloma by Insulin Like Growth Factor I (IGF-I). C-MYC Impairs Immunogenicity of Human B Cells. Cancer Dormancy: Lessons From a B Cell Lymphoma and Adenocarcinoma of the Prostate. Therapeutic Targets of Multiple Angiogenic Factors for the Treatment of Cancer and Metastasis.

Volume

v. 98 ISBN 9780123738967

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, "Molecular Oncology - From Bench to Bedside," held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein's combined 160th birthday. To honor this occasion, this 2nd of two volumes brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called "Foundations in Cancer Research" was initiated and the tributes honoring the Kleins' bodies of work presented at the minisymposium are especially appropriate for the series.

Table of Contents

Why Do We Not All Die of Cancer at an Early Age? The Early History of Plasma Cell Tumors in Mice, 1954-1976 Mouse Mammary Tumor Biology: A Short History Ordered Heterogeneity and Its Decline in Cancer and Aging Reversal of Tumor Resistance to Apoptotic Stimuli by Alteration of Membrane Fluidity: Therapeutic Implications Mutant Transcription Factors and Tyrosine Kinases as Therapeutic Targets for Leukemias: From Acute Promyelocytic Leukemia to Chronic Myeloid Leukemia and Beyond The Effect of Cell-Matrix Interactions and Aging on the Malignant Process Index

Volume

v. 99 ISBN 9780123742247

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer. Immunotherapy

Table of Contents

Chapter 1: FOUNDATIONS IN CANCER RESEARCH: The Turns of Life and Science Chapter 2: RUNX Genes in Development and Cancer: Regulation of Viral Gene Expression and the Discovery of RUNX Family Genes. Chapter 3: The RNA Continent. Chapter 4: The c-myc Promoter: Still MysterY and Challenge. Chapter 5: Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond. Chapter 6: Dendritic Cells in Cancer Immunotherapy.

Volume

v. 100 ISBN 9780123743589

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer Immunotherapy.

Volume

v. 101 ISBN 9780123743596

Description

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including cancer cell migration and invasion, human tumor suppressors, FAK expression, adhesion proteins, homeobox genes in cancer development, glucocorticoid-induced apoptosis, histocompatibility antigens in tumors, NKT cells, chronic immune activation, and cancer cells and leukocytes.

Table of Contents

Chapter 1 Contribution of AZAP Type Arf GAPs to Cancer Cell Migration and Invasion Chapter 2 Role and Regulation of Human Tumor Suppressor SUFU in Hedgehog Signaling Chapter 3 FAK Expression: Regulation and Therapeutic Potential Chapter 4 Adhesion Proteins Meet Receptors: A Common Theme? Chapter 5 The Six Family of Homeobox Genes in Development and Cancer Chapter 6 Mechanisms Regulating the Susceptibility of Hematopoietic Malignancies to Glucocorticoid-Induced Apoptosis Chapter 7 IFN Inducibility of Major Histocompatibility Antigens in Tumors Chapter 8 The Role of NKT Cells in Tumor Immunity Chapter 9 HIV Induced AIDS and Related Cancers: Chronic Immune Activation and Future Therapeutic Strategies Chapter 10 The Cancer Cell-Leukocyte Fusion Theory of Metastasis

Volume

v. 102 ISBN 9780123744371

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including tumor dormancy, micro RNA, tumor angiogenesis, cancer in mouse models, liposome based chemo and autoimmunotherapy, signaling in angiogenesis, targeted cancer therapy, and regulatory t-cells.

Table of Contents

1: Tumor Dormancy and Metastasis 2: The Role of Micro RNA in CLL 3: Tumor Angiogenesis and Wound Repair 4: Deciphering the Complexities of Cancer in Mouse Models 5: Liposome Based Chemo and Autoimmunotherapy: From Basic Research to Approved Drugs 6: P13K/PTEN Signaling in Angiogenesis and Tumorigenesis 7: The Trail to the Targeted Therapy of Breast Cancer 8: Regulatory T-Cells

Volume

v. 107 ISBN 9780123747709

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

Chapter 1 Breaking Tolerance in a Mouse Model of Multiple Myeloma by Chemoimmunotherapy Amir Sharabi and Nechama Haran Ghera Chapter 2 Obesity, Cholesterol and Clear-Cell Renal Cell Carcinoma (RCC) Harry A. Drabkin and Robert M. Gemmill Chapter 3 Regulatory T Cells in Cancer Dimitrios Mougiakakos, Aniruddha Choudhury, Alvaro Lladser, Rolf Kiessling, and C. Christian Johansson Chapter 4 Role of EBERs in the Pathogenesis of EBV Infection Dai Iwakiri and Kenzo Takada Chapter 5 Androgen Regulation of Gene Expression Kristin R. Lamont and Donald J. Tindall

Volume

v. 106 ISBN 9780123747716

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including liposome-based chemotherapy and immunotherapy, human polyomaviruses, the role of micro RNAs in CLL, and cancer and cholesterol.

Table of Contents

Chapter 1 Insights into the Evolution of Lymphomas Induced by Epstein-Barr Virus David Vereide and Bill Sugden Chapter 2 Update on Human Polyomaviruses and Cancer Ole Gjoerup and Yuan Chang Chapter 3 The Tyrosine Phosphatase Shp2 in Development and Cancer Katja S. Grossmann, Marta Rosario, Carmen Birchmeier, and Walter Birchmeier Chapter 4 CXC Chemokines in Cancer Angiogenesis and Metastases Ellen C. Keeley, Borna Mehrad, and Robert M. Strieter Chapter 5 Genetically Engineered Mouse Models in Cancer Research Jessica C. Walrath, Jessica J. Hawes, Terry Van Dyke, and Karlyne M. Reilly

Volume

v. 103 ISBN 9780123747730

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papillomavirus, and modeling prostate cancer in the mouse.

Table of Contents

Liposome based chemo- and immunotherapy: From basic research to approved drugs. (Yechezkel Barenholz) Tumor Angiogenesis and Wound Repair (Nancy Boudreau) Tumor Dormancy and Metastasis (Ann F. Chambers) The Role of Micro RNAs in CLL (Carlo Croce) P13K/PTEN signaling in angiogenesis and tumorigenesis (Bing-Hua Jiang) The TRAIL to the Targeted Therapy of Breast Cancer (Stan Lipkowitz) Regulatory T-Cells (Danila Valmori) Deciphering the complexities of cancer in mouse models (Terry Van Dyke)

Volume

v. 108 ISBN 9780123808882

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

Chapter 1 Insights into the Evolution of Lymphomas Induced by Epstein-Barr Virus David Vereide and Bill Sugden Chapter 2 Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma: Epidemiological and Molecular Biological Aspects Jia-Horng Kao, Pei-Jer Chen, and Ding-Shinn Chen Chapter 3 The ATM-Chk2 and ATR-Chk1 Pathways in DNA Damage Signalling and Cancer Joanne Smith, Lye Mun Tho, and David A. Gillespie Chapter 4 microRNAs in Cancer: From Bench to Bedside Maria Angelica Cortez, Cristina Ivan, Peng Zhou, Xue Wu, Mircea Ivan, and George Adrian Calin

Volume

v. 109 ISBN 9780123808905

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

Chapter 1 Mechanisms of Prostate Cancer Initiation and Progression Beatrice Knudsen and Valera Vasioukhin Chapter 2 Genetic Basis for Susceptibility to Lung Cancer: Recent Progress and Future Directions Jun Yokota, Kouya Shiraishi, and Takashi Kohno Chapter 3 Functional and Clinical Relevance of Chondroitin Sulfate Proteoglycan 4 Michael Campoli, Soldano Ferrone, and Xinhui Wang Chapter 4 KRAS Signaling Pathway Alterations in Microsatellite Unstable Gastrointestinal Cancers Sergia Velho, Giovanni Corso, Carla Oliveira, and Raquel Seruca

Volume

v. 111 ISBN 9780123855244

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Volume

v. 110 ISBN 9780123864697

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics

Table of Contents

Chapter 1 Hedgehog Signaling and Pancreatic Tumor Development Matthias Lauth and Rune Toftgard Chapter 2 The Microenvironment and Molecular Biology of the Multiple Myeloma Tumor Miguel Lemaire, Sarah Deleu, Elke De Bruyne, Els Van Valckenborgh, Eline Menu, and Karin Vanderkerken Chapter 3 Chromatin Insulators: A Role in Nuclear Organization and Gene Expression Jingping Yang and Victor G. Corces Chapter 4 Proteolytic Control of the Oncoprotein Transcription Factor Myc Lance R. Thomas and William P. Tansey Chapter 5 TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade Thierry Soussi

Volume

v. 113 ISBN 9780123942807

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

The AID dilemma: infection, or cancer? The microRNA regulatory network in normal- and HTLV-1-transformed T cells The multifaceted oncoprotein Tax: Sub-cellular localization, post-translational modifications and NF-?B activation Lynch or not Lynch? Is that always a question? Activation induced deaminase in antibody diversification and chromosome translocation Opportunities and challenges in tumor angiogenesis research: back and forth between bench and bed Molecular Logic Underlying Chromosomal Translocations, Random or non-Random?

Volume

v. 118 ISBN 9780124071735

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

1. Role of Oxidative Stress and Microenvironment in Breast Cancer Development and Progression 2. Bioengineering Strategies for Cancer Targeting 3. Advances in Understanding the Coupling of DNA Base Modifying Base Enzymes to Processes Involving Base Excision Repair 4. Recent Advances in the Treament of Prostrate Cancer Stemming from Improvements in the Biology of the Disease 5. Autophagy: Cancer's Friend or Foe

Volume

v. 119 ISBN 9780124071902

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

Vaccines for Cancer: Past, Present and Future Understanding the role of Ets-mediated gene regulation in complex biological processes Non-Small Cell Lung Cancer Mitochondrial Alterations During Carinogenesis Human polynucleotide phosphorylase (hPNPaseold-35): should I eat you or not- that is the question?

Volume

v. 121 ISBN 9780128002490

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

1. Glial Progenitors as Targets for Transformation in Glioma2. Therapeutic Cancer Vaccines 3. IKK/Nuclear Factor-kappaB and Oncogenesis: Roles in Tumor Initiating Cells and in the Tumor Microenvironment4. The Rb-E2F Transcriptional Regulatory Pathway in Tumor Angiogenesis and Metastasis5. ATP-Dependent Chromatin Remodeling Complexes as Novel Targets for Cancer Therapy6. Diffuse Intrinsic Pontine Gliomas: Treatments and Controversies7. In Vivo Modeling of Malignant Glioma: The Road to Effective Therapy8. Genetically Engineered Mice as Experimental Tools to Dissect the Critical Events in Breast Cancer9. Life is Three-Dimensional - As in vitro Cancer Cultures Should be

Volume

v. 127 ISBN 9780128029206

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including taxane-anti-androgens cross-resistance in advanced prostate cancer and proteasome inhibitors in the treatment of multiple myeloma.

Table of Contents

1. Unravelling the Complexity and Functions of MTA Coregulators in Human CancerDa-Qiang Li, Rakesh Kumar2. Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic DatasetsManny D. Bacolod , Swadesh K. Das , Upneet K. Sokhi, Steven Bradley , David A. Fenstermacher , Maurizio Pellecchia, Luni Emdad, Devanand Sarkar and Paul B. Fisher 3. Exploitation of the Androgen Receptor to Overcome Taxane Resistance in Advanced Prostate Cancer Sarah K. Martin and Natasha Kyprianou 4. Stem Cell-Based Therapies for Cancer Deepak Bhere and Khalid Shah5. Emerging Therapeutic Strategies for Overcoming Proteasome Inhibitor Resistance Nathan G. Dolloff6. Influence of Bone Marrow Microenvironment on Leukemic Stem Cells: Breaking up an Intimate RelationshipPuneet Agarwal and Ravi Bhatia7. Perspectives on Epidermal Growth Factor Receptor Regulation in Triple-negative Breast Cancer: Ligand-mediated Mechanisms of Receptor Regulation and Potential for Clinical TargetingCarly Bess Williams, Adam C. Soloff, Stephen P. Ethier, and Elizabeth S. Yeh8. The Quest for an Effective Treatment for an Intractable Cancer: Established and Novel Therapies for Pancreatic AdenocarcinomaBridget A. Quinn, Nathaniel A. Lee, Timothy P. Kegelman, Praveen Bhoopathi, Luni Emdad, Swadesh K. Das, Maurizio Pellecchia, Devanand Sarkar and Paul B. Fisher

Volume

v. 131 ISBN 9780128047880

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Table of Contents

1. The Dual Role of Senescence in Pancreatic Ductal AdenocarcinomaAngelo Porciuncula, Cristina Hajdu and Gregory David2. Small Molecule Targeting of BET Proteins in CancerChristopher A. French3. H3K27 Methylation: A Focal Point of Epigenetic Deregulation in CancerJessica N. Nichol, Daphne Dupere-Richer, Teresa Ezponda, Jonathan D. Licht, Wilson H. Miller and Jr.4. AEG1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity and CNS DiseasesLuni Emdad, Swadesh K. Das, Bin Hu, Timothy Kegelman, Dong-chul Kang, Seok-Geun Lee, Devanand Sarkar and Paul B. Fisher5. Role of the RB Interacting Proteins in Stem Cell BiologyM. Mushtaq, H. Vinas Gaza and E.V. Kashuba6. Evolving Strategies for Therapeutically Targeting Cancer Stem Cells (CSCs)Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar and Paul B. Fisher

Volume

v. 130 ISBN 9780128047897

Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research, presenting outstanding and original reviews on a variety of topics.

Table of Contents

1. The Evolving, Multifaceted Roles of Autophagy In CancerJennifer Liu and Jayanta Debnath2. Inhibitors of DNA Methylation, Histone Deacetylation and Histone Demethylation: A Perfect Combination for Cancer TherapyCynthia A. Zahnow, Michael Topper, Meredith Stone, Tracy Murray-Stewart, Huili Li, Stephen B. Baylin, and Robert A. Casero, Jr.3. Emerging Roles of Epigenetic Regulator Sin3 in CancerNidhi Bansal, Gregory David, Eduardo Farias and Samuel Waxman4. PAKs in Human Cancer Progression - From Inception to Therapeutic to Future Oncobiology Rakesh Kumar and Da-Qiang Li5. Sirtuins and the Estrogen Receptor as Regulators of the Mammalian Mitochondrial UPR in Cancer and AgingDoris Germain6. Keratinocyte Carcinoma as a Marker of a High Cancer-Risk PhenotypeJames Small, Virginia Barton, Brett Peterson and Anthony J. Alberg

Volume

v. 137 ISBN 9780128151235

Description

Advances in Cancer Research, Volume 137, the latest release in this ongoing, well-regarded serial provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, with this volume covering unconventional approaches to modulating the immunogenicity of tumor cells, tumor dormancy and immunoediting, the emerging role of anti-apoptotic Bcl-2 family proteins in chemoresistance, Beclin-1 and autophagy, MDA-7/IL-24, and nanotechnology and medicine.

Table of Contents

1. Unconventional approaches to modulating the immunogenicity of tumor cellsPaul Dent2. Tumor dormancy and immunoeditingMasoud H. Manjili3. Emerging role of anti-apoptotic Bcl-2 family proteins in chemoresistanceRupesh Dash4. Beclin-1 and AutophagyPaul Fisher5. Nanotechnology and MedicineRajagopal Ramesh6. PENDING TITLEMonica Valentovic

Volume

v. 138 ISBN 9780128151273

Description

Advances in Cancer Research, Volume 138, the latest release in this ongoing, well-regarded serial provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, with this volume covering unconventional approaches to modulating the immunogenicity of tumor cells, tumor dormancy and immunoediting, the emerging role of anti-apoptotic Bcl-2 family proteins in chemoresistance, Beclin-1 and autophagy, MDA-7/IL-24, and nanotechnology and medicine.

Table of Contents

1. Leveraging Epigenetics to Enhance the Cellular Response to Chemotherapies and Improve Tumor ImmunogenicityLiliya Tyutyunyk-Massey, Syed Haqqani, Reshma Mandava, Kirubel Kentiba, Mallika Dammalapati, Nga Dao, Joshua Haueis, David Gewirtz and Joseph W. Landry2. VDAC Regulation: A Mitochondrial Target to Stop Cell ProliferationDiana Fang and Eduardo N. Maldonado3. Acquired Resistance to Drugs Targeting Tyrosine KinasesSteven A. Rosenzweig4. Extracellular Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological OutcomesScott T. Eblen5. Role of MDA-7/IL-24 a Multifunction Protein in Human DiseasesMitchell E. Menezes, Praveen Bhoopathi, Anjan K. Pradhan, Luni Emdad, Swadesh K. Das, Chunqing Guo, Xiang-Yang Wang, Devanand Sarkar and Paul B. Fisher6. Advances and Challenges of HDAC Inhibitors in Cancer TherapeuticsJesse J. McClure, Xiaoyang Li and C. James Chou7. Prospects of Gene Therapy to Treat MelanomaMitchell E. Menezes, Sarmistha Talukdar, Stephen L. Wechman, Swadesh K. Das, Luni Emdad, Devanand Sarkar and Paul B. Fisher

Volume

v. 142 ISBN 9780128171530

Description

Advances in Cancer Research, Volume 142, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research.

Table of Contents

1. Highly variant DNA methylation in normal tissues identifies a distinct subclass of cancer patientsJayashri Ghosh, Bryant Schultz, Christos Coutifaris and Carmen Sapienza2. Bittersweet tumor development and progression: Emerging roles of epithelial plasticity glycosylationsRyan M. Phillips, Christine Lam, Hailun Wang and Phuoc T. Tran3. The second genome: Effects of the mitochondrial genome on cancer progressionAdam D. Scheid, Thomas C. Beadnell and Danny R. Welch4. Pathways- and epigenetic-based assessment of relative immune infiltration in various types of solid tumorsManny D. Bacolod, Francis Barany, Karsten Pilones, Paul B. Fisher and Romulo J. de Castro5. HVEM network signaling in cancerJohn R. Sedy and Parham Ramezani-Rad6. Pharmacology of ME-344, a novel cytotoxic isoflavoneLeilei Zhang, Jie Zhang, Zhiwei Ye, Danyelle M. Townsend and Kenneth D. Tew

Volume

v. 144 ISBN 9780128171554

Description

Advances in Cancer Research, Volume 144, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research. Chapters in this new release include Gene-Environment-Microenvironment Interactions in Melanomagenesis, PP2A and the Cell Cycle, Current Progress Defining Calcium Signals as Therapeutic Targets in Cancer Cells, and much more.

Table of Contents

1. Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesisXuan Mo, Sarah Preston and M. Raza Zaidi2. PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancerHolly Fowle, Ziran Zhao and Xavier Grana3. Clinical and translational advances in esophageal squamous cell carcinomaZachary Wilmer Reichenbach, Mary Grace Murray, Reshu Saxena, Daniel Farkas, Erika G. Karassik, Alena Klochkova, Kishan Patel, Caitlin Tice, Timothy M. Hall, Henry P. Parkman, Sarah J. Ward, Marie-Pier Tetreault and Kelly A. Whelan4. MDA-9/Syntenin: An emerging global molecular target regulating cancer invasion and metastasisSwadesh K. Das, Devanand Sarkar, Luni Emdad and Paul B. Fisher5. Expression of costimulatory and inhibitory receptors in FoxP3+ regulatory T cells within the tumor microenvironment: Implications for combination immunotherapy approachesAras Toker and Pamela S Ohashi6. Capsaicinoids enhance chemosensitivity to chemotherapeutic drugsJamie R. Friedman, Stephen D. Richbart, Justin C. Merritt, Haley E. Perry, Kathleen C. Brown, Austin T. Akers, Nicholas A. Nolan, Cathryn D. Stevenson, John D. Hurley, Sarah L. Miles, Maria T. Tirona, Monica A. Valentovic and Piyali Dasgupta7. Marine natural products in the discovery and development of potential pancreatic cancer therapeuticsXiaojuan Wang and Mark T. Hamann8. Cancer stem cells in breast and prostate: Fact or fictionSampayo, Rocio G and Bissell, Mina J9. Racial disparities, cancer and response to oxidative stressJie Zhang, Zhi-wei Ye, Danyelle M. Townsend, Chanita Hughes Halbert and Kenneth D. Tew

by "Nielsen BookData"

Details

• NCID: BA00351632
• ISBN:
  • 012006636X
  • 0120066378
  • 0120066386
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  • 9780120066971
  • 9780123738967
  • 9780123742247
  • 9780123743589
  • 9780123743596
  • 9780123744371
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  • 9780123747716
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  • 9780128047880
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  • 9780128151273
  • 9780128171530
  • 9780128171554
• LCCN: 52013360
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Orlando ; Tokyo
• Pages/Volumes: v.
• Size: 24 cm
• Classification:
  • NLM : W1
• Subject Headings:
  • MESH : Neoplasms, Experimental