Synthetic peptides as antigens
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Bibliographic Information
Synthetic peptides as antigens
（Ciba Foundation symposium, 119）
Wiley, 1986
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"Symposium on synthetic peptides as antigens, held at the Ciba Foundation, London, 4-6 June 1985"
Description and Table of Contents
Description
Synthetic peptides as antigens Ciba Foundation Symposium 119 Chairman: Gordon L. Ada 1986 Vaccination is a major means of combating infectious disease but no effective vaccine is available yet for many parasitic, viral and bacterial infections. A new approach consists of vaccines based on synthetic peptides rather than native parent antigens. The contributors to this symposium discuss the antigenicity and immunogenicity of synthetic peptides and their potential use in vaccines against malaria and other serious diseases. They consider the relationship between protein conformation and antigenicity, including the role of localized mobility and the conformational changes induced when peptides bind with immunoglobulin. A new method of synthesizing peptides able to mimic discontinuous epitopes is described. The symposium opens with a review of the regulation of immune responses in vivo. Carrier molecules such as PPD are being investigated; carrier choice plays a crucial role in the anti-hCG vaccine (based on a synthetic peptide) being tested as a means of birth control, and discussed here.
Synthetic peptides are also of use as research tools, as described for the analysis of IgG sites responsible for autoantibody production in rheumatoid arthritis, and the localization of the c-myc oncoprotein in normal and transformed cells and in tumour masses. Other Ciba Foundation Symposia published by Pitman: No 114: Fibrosis Chairman: A.J. Bailey 1985 ISBN 0 272 79814 2 No 116: Growth factors in biology and medicine Chairman: Sir Michael Stoker 1985 ISBN 0 272 79818 5 No 118: Biochemistry of macrophages Chairman: Z.A. Cohn 1986 ISBN 0 272 79822 3
Table of Contents
Symposium on Synthetic Peptides as Antigens, held at the Ciba Foundation, London, 4 6 June 1985. The subject of this symposium was proposed by P. Dukor and D. G. Braun. Editors: Ruth Porter (Organizer) and Julie Whelan. G. L. Ada Introduction. J. H. Humphrey Regulation of in vivo immune responses: few principles and much ignorance. Discussion. P. J. Lachmann, L. Strangeways, A. Vyakarnam and G. I. Evan Raising antibodies by coupling peptides to PPD and immunizing BCG-sensitized animals. Discussion. H. J. Dyson, K. J. Cross, J. Ostresh, R. A. Houghten, I. A. Wilson, P. E. Wright and R. A. Lerner Selection by site-directed antibodies of small regions of peptides which are ordered in water. Discussion. M. H. V. Van Regenmortel, D. Altschuh and A. Klug Influence of local structure on the location of antigenic determinants in tobacco mosaic virus protein. Discussion. M. J. Crumpton The importance of conformation and of equilibria in the interaction of globular proteins and their fragments with antibodies. Discussion. A. B. Edmundson and K. R. Ely Three-dimensional analyses of the binding of synthetic chemotactic and opioid peptides in the Mcg light chain dimer. Discussion. H. M. Geysen, S. J. Rodda and T. J. Mason The delineation of peptides able to mimic assembled epitopes. Discussion. V. Nussenzweig and R. S. Nussenzweig Experimental basis for the development of a synthetic vaccine against Plasmodium falciparum malaria sporozoites. Discussion. R. F. Anders, P-T. Shi, D. B. Scanlon, S. J. Leach, R. L. Coppel, G. V. Brown, H-D. Stahl and D. J. Kemp Antigenic repeat structures in proteins of Plasmodium falciparum. Discussion. M. Sela, R. Arnon and C. O. Jacob Synthetic peptides with antigenic specificity for bacterial toxins. Discussion. V. C. Stevens Use of synthetic peptides as immunogens for developing a vaccine against human chorionic gonadotropin. Discussion. D. R. Stanworth, D. S. Butt and G. Z. Hastings The use of synthetic peptides in the delineation of immunoglobulin antigenic epitopes and Fc effector functions. Discussion. G. I. Evan, D.C. Hancock, T. Littlewood and C. D. Pauza Characterization of the human c-myc protein using antibodies prepared against synthetic peptides. Discussion. S. S. Alkan and D. G. Braun Epitope mapping of human recombinant interferon alpha molecules by monoclonal antibodies. Discussion. Final general discussion Reactivity of anti-peptide antibodies with the parent proteins. The proportion of monoclonal antibodies reactive to conformational or other linear sequences. High and low affinity antibodies and their roles. T-dependent and T-independent antigen presentation. G. L. Ada Chairman's summing-up. Index of contributors. Subject index
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