Chemistry, biology, and medicine of neurohypophyseal hormones and their analogs

著者

• Smith, Clark W.

書誌事項

Chemistry, biology, and medicine of neurohypophyseal hormones and their analogs

ed. by Clark W. Smith

（The Peptides : analysis, synthesis, biology / edited by Erhard Gross, Johannes Meienhofer, v. 8）

Academic Press, 1987

注記

Includes bibliographies and indexes

内容説明・目次

内容説明

Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs, Volume 8 covers the advances in methods to study peptide hormone action at the molecular level. The book discusses the anatomy, physiology, and clinical disorders of the neurohypophysis; the biosynthesis of neurohypophyseal peptides; and the structure-activity relationships of neurohypophyseal peptides, with an emphasis on the role of conformational features. The text also describes conformational studies of neurohypophyseal hormones by physical chemical techniques; the central nervous system effects of neurohypophyseal peptides; and the effects of neurohypophyseal hormones on the kidney. The effects of neurohypophyseal hormones on the cardiovascular systems are also considered. Chemists, neurobiologists, and people involved in the study of neurohypophyseal hormones will find the book invaluable.

目次

Preface IX Chapter 1 Clinical Disorders of the Neurohypophysis I Anatomy II Synaptic Input III Physiology IV Pathophysiologic Mechanisms V Hypofunction of the Neurohypophysis: Diabetes Insipidus VI Hyperfunction of the Posterior Pituitary-Syndrome of Inappropriate Secretion of Antidiuretic Hormone References Chapter 2 The Other Neurohypophyseal Peptides I Introduction II Opioid Peptides III Hypothalamic Releasing and Release-Inhibiting Factors IV Gastrointestinal Peptides V Other Peptides VI Physiological Significance of Other Neurohypophyseal Peptides References Chapter 3 Biochemistry and Biology of Vasopressin, Oxytocin, and Their Corresponding Neurophysins I Introduction II Structural Aspects-Polyproteins III Vasopressin and Oxytocin-Functional Aspects IV Gene Structure V Comparison of the Bovine and Rat Genes VI Transcriptional Control VII Precursor Structure VIII Processing and Modifications IX Genetic Defect-Diabetes Insipidus X Expression in Peripheral Tissues XI Perspectives References Chapter 4 Structure-Activity Relationships of Neurohypophyseal Peptides I. Introduction II. Naturally Occurring Neurohypophyseal Hormones-An Overview III. Structure-Activity Relationships of Oxytocin Agonists IV. Structure-Activity Relationships of Antagonist Analogs of the Neurohypophyseal Hormones That Competitively Block the Actions of the Native Hormone at Receptors for Oxytocin V. Structure-Activity Relationships of Vasopressin Agonists VI. Antagonist Analogs of the Neurohypophyseal Hormones That Competitively Block the Action(s) of the Native Hormones at Receptors for Vasopressin VII. Concluding Remarks References Chapter 5 The Conformation of Neurohypophyseal Hormones I Introduction II Theories Relating Conformation to Activity III Conformational Assignments IV Energy-Based Molecular Modelling V Summary and Conclusions Chapter 6 Central Nervous System Effects of Neurohypophyseal Peptides I Introduction II Animal Studies III Human Studies-Neurohypophyseal Peptides and Memory IV Neurohypophyseal Peptides and Drug Tolerance and Dependence V Effects of Oxytocin in the CNS VI CNS Effects of Neurohypophyseal Peptides Not Related to Learning or Memory VII Possible Sites and Mechanisms of Action of Neurohypophyseal Peptides in the CNS VIII Conclusions References Chapter 7 Renal Effects and Hormonal Interaction with the Neurohypophyseal Hormone, Vasopressin I Introduction II Nephron Sites of AVP Action III Cellular Action of Hydroosmotic Action of AVP IV Modulating Factors of AVP Action V Interactions of Other Hormones and AVP VI Role of AVP in Pathophysiological States VII Effect of AVP on Chloride and Other Electrolyte Transport VIII Effect of AVP on Renal Hemodynamics IX Effect of AVP on Renin Secretion X Other Renal Effects and Metabolism XI AVP Antagonists References Chapter 8 Cardiovascular Effects of Neurotiypophyseal Peptides I Effects on Cells II Local Effects on Regional Vascular Tissues III Integrated Hemodynamic Effects IV Effects of Vasopressin on Neural Control of Circulation V Agonists and Antagonists Used to Study Cardiovascular Effects VI Summary References Index

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詳細情報

• NII書誌ID(NCID): BA00429820
• ISBN:
  • 0123042089
• LCCN: 78031958
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York
• ページ数/冊数: x, 370 p.
• 大きさ: 24 cm
• 分類:
  • LCC : QP552.P4
  • DC19 : 574.1/92456
• 件名:
  • LCSH : Peptides -- Collected works
  • MESH : Peptides
• 親書誌ID:
  • BA00430116