Pharmacological aspects of heart disease : proceedings of an International Symposium on Heart Metabolism in Health and Disease and the Third Annual Cardiology Symposium of the University of Manitoba, July 8-11, 1986, Winnipeg, Canada
著者
書誌事項
Pharmacological aspects of heart disease : proceedings of an International Symposium on Heart Metabolism in Health and Disease and the Third Annual Cardiology Symposium of the University of Manitoba, July 8-11, 1986, Winnipeg, Canada
(Developments in cardiovascular medicine, v. 68)
Nijhoff , Distributors for the U.S. and Canada, Kluwer Academic Publishers, c1987
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
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  アメリカ
注記
Includes bibliographies
内容説明・目次
内容説明
The importance of heart and artery disease as a cause of death and disability is difficult to exaggerate: it causes over half of all deaths in the western world and now accounts for one-quarter of deaths in the entire world. This appalling incidence persists in spite of commendable progress in treatment and prevention, particularly in the last two or three decades. Deaths from coronary disease have decreased by a third in the past twenty years and stroke has decreased by a half in the same period. This remarkable improvement, saving thousands of lives per year, has come about due to changes in life style (low fat diet, control of high blood pressure, less smoking and more exercise) and progress in treatment (more effective drugs, coronary care units, pacemakers, and cardiac surgery). Progress in understanding the pathophysiologic and pharn,acologic mechanisms operative in heart disease have been paramount in the development of more rational and more effective therapy. Dramatic and spectacular surgical treatments have fired the public imagination. Bypass surgery is commonplace and results in complete or considerable relief of symptoms in the majority of patients operated upon.
目次
Preface.- Acknowledgements.- A. Antiarrhythmic Agents.- 1. Approaches to the Selection of an Antiarrhythmic Drug.- 2. Antiarrhythmic Action of Calcium Antagonists.- 3. Ouinidine Reduces Outward Current in Single Canine Cardiac Purkinje Cells.- 4. Antiarrhythmic Drug Therapy for Patients with Ventricular Tachyarrhythmias in the Setting of Left Ventricular Dysfunction: 1. The Role of Propafenone, 2. The Role of Adjunct Beta-Blockade.- 5. Protective Effect of Nifedipine upon Ouabain-Induced Arrhythmias.- 6. Effect of Isoprenaline or Stress on Adrenaline-Induced Arrhythmias in Albino Rats.- B. Therapy Of Hypertension And Heart Failure.- 7. Clinical Trials in Hypertension and Congestive Heart Failure.- 8. Interaction of Calcium Entry Blockers and Adrenergic System in Hypertension and Heart Failure.- 9 Prazosin Therapy in Chronic Congestive Heart Failure.- 10. Influences of a Long-Term Treatment with Antihypertensive Drugs on Left Ventricular Myosin Isoenzyme Pattern in Spontaneously Hypertensive Rats.- 11. Enhanced Action of Nifedipine upon Vascular Smooth Muscle from Hypertensive Rats.- 12. Ajmaloon a Unique Herbal Polypharmaceutical Possessing Both Hypotensive and Cadmium Lowering Property.- 13. Pathophysiology and Treatment of Decreased Cardiac Output Complicating Pulmonary Hypertension.- C. Calcium Antagonists And Beta Adrenergic Receptor Blockers.- 14. Ca Antagonists in Cardiopulmonary Changes Induced by High Altitude Hypoxia.- 15. Effect of Crystalloid Cardioplegia and Diltiazem on the Cardiac Function and Some Biochemical Parameters During Hypothermic Cardiac Arrest Using Cardiopulmonary Bypass.- 16. Effects of Verapamil on Metabolism and Function of Hearts From Normal and Hyperthyroid Rats.- 17. Regulation of Beta-Adrenergic Pathways in the Heart.- 18. Involvement of ?2-adrenergic Receptors in the Potentiation of the Chronotropic Action of Isoprenaline Evoked in Rocker-Cultured Neonatal Rat Heart Cells by Pyruvate and L(+)-Lactate.- 19. Cardiac Effects of ?-Adrenergic Blockers in Combination with Metabolic Interventions.- 20. Local Adrenergic Effects on Metabolism in Heart and Skeletal Muscle in Man.- D. Cardiac Glycosides And Sodium Pump.- 21. Multiple Forms of the Cardiac Glycoside Receptor with Different Affinities for Cardiac Glycosides.- 22. Modulation of Glycoside Sensitivity of the Cardiac Sodium Pump.- 23. Up and Down Regulation of the Sodium Pumping Sites in Myocardium.- 24. Sensitivity of the Hypertrophied Heart to Ouabain. An In Vivo and In Vitro Study..- 25. Mitochondrial Calcium Overload in Digitalis-Induced Mechanical Toxicity.- E. Newer Inotropic Agents And Calcium.- 26. Classification and Mechanism of Action of the Cardiac Inotropic Agents: An Overview.- 27. New Approaches for the Treatment of the Failing Myocardium: Myofibrillar Proteins as Potential Targets for Pharmacotherapy.- 28. The Role of the Lipid Bilayer in Amphiphile-Membrane/Receptor Interactions: A Unifying Hypothesis.- 29. Forskolin, A New Inotropic Agent.- 30. Dependence of Vasoconstrictor Responses on Extracellular Calcium.- 31. Cytosolic Free Calcium Transients Induced by Ergonovine in Cultured Vascular Smooth Muscle Cells.
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