Papillomaviruses
著者
書誌事項
Papillomaviruses
（Ciba Foundation symposium, 120）
J. Wiley, 1986
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注記
Proceedings of the Symposium on Papillomaviruses, held at the Ciba Foundation, London, 9-11 July 1985; editors, David Evered (organizer) and Sarah Clark
Includes bibliographies and indexes
内容説明・目次
内容説明
Papillomaviruses cause benign papillomas in humans and other mammals, but concern about their association with certain malignant lesions and appreciation of their heterogeneity (over 30 different types exist) have recently heightened interest in the genus. This multidisciplinary symposium volume brings together new research on molecular biological, physiological and clinical aspects of papillomaviruses, focusing on the virus - host interaction and the links between genomic organization and the pathological consequences of infection. The book starts with discussion of the classification and molecular genetics of papillomaviruses, with emphasis on transcriptional control, transforming functions and plasmid replication. The in vitro studies described provide clues to how benign papillomavirus-associated lesions might progress to malignancy. The nature and range of papillomavirus-associated diseases are then explored by reference to diverse lesions, from skin warts and laryngeal papillomatosis to epidermodysplasia verruciformis, bovine carcinomas of the bladder and alimentary tract and human cervical carcinoma.
The potential of both vaccines and interferon in preventing or treating such disorders is also assessed. It is stressed throughout that problems remain in establishing the oncogenicity of papillomaviruses and evaluating the possible roles of cocarcinogens and immunosuppression, and that despite improved methods for diagnosing infection there is still much to be learnt about the natural history of the viruses.
目次
- Partial table of contents: Classification of the Papillomaviruses (H. Pfister et al.). Organization and Expression of the Genome of Bovine Papillomavirus Type I (U. Pettesson et al.). Papillomavirus Transforming Functions (P. Howley et al.). The bovine papillomavirus replicon (M. Botchan et al.). General Discussion I: The E6 Protein. Criteria for Establishing that a Virus is Oncogenic (L. Crawford). Persistence and Expression of Human Papillomavirus DNA in Genital Cancer (L. Gissmann and E. Schwartz). Papillomaviruses and interferon (E. Androphy). General Discussion II: Epidemiological Trends and Legal Aspects
- Sites, Types and Transmission of Infection
- Immunosuppression and Infection. Index of Contributors. Subject Index.
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