Biology of proteoglycans
著者
書誌事項
Biology of proteoglycans
(Biology of extracellular matrix, A series)
Academic Press, 1987
大学図書館所蔵 全26件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographies and index
内容説明・目次
内容説明
Biology of Proteoglycans provides a representative, but by no means inclusive, sample of current research on the role of proteoglycans in the cell biology of the extracellular matrix. The book is organized into four areas: methodological developments; proteoglycan metabolism; proteoglycans in cartilage; and proteoglycans in "soft" tissues. It begins with discussions of current methodological developments which have had enormous impact on understanding the complexity of proteoglycan structure. These include the use of monoclonal antibodies to probe the structure of the protein and carbohydrate portions of proteoglycans; and studies on the genes that code for the proteoglycan protein cores and associated proteins. This is followed by separate chapters on various aspects of proteoglycan metabolism, including the synthetic pathway used by cells to synthesize proteoglycans containing heparin and heparan sulfate; the molecular organization of different proteoglycans in cartilage; the role of proteoglycans and associated proteins in the calcification process in growth plate; and the emerging field of proteoglycans in "soft" or noncartilagenous tissue.
目次
Preface
Monoclonal Antibodies as Probes for Elucidating Proteoglycan Structure and Function
I. Introduction
II. Production, Screening, and Characterization of Monoclonal Antibodies Directed against Epitopes Present on Proteoglycan Substructures
III. Monoclonal Antibodies to Epitopes Present on Proteoglycan Monomers
IV. Monoclonal Antibodies to the Link Proteins of Cartilage Proteoglycan Aggregate
V. General Discussion
References
Molecular Biology of Proteoglycans and Link Proteins
I. Perspectives
IL Cell-Free Translation of mRNAs Encoding Proteoglycan Core Proteins and Link Proteins
III. Cloning of Proteoglycan Core Protein and Link Protein cDNAs
IV. Prospectives
References
Biosynthesis of Heparin and Heparan Sulfate
I. Introduction
II. The Proteoglycans-Structures and Interactions
III. Outline of the Biosynthetic Process
IV. Regulation of Polymer Modification
V. Organization of the Biosynthetic Apparatus
VI. Perspectives for the Future
References
Proteoglycan Metabolism by Rat Ovarian Granulosa Cells In Vitro
I. Introduction
II. Characterization of Granulosa Cell Proteoglycans
III. Metabolism of Granulosa Cell Proteoglycans
IV. General Considerations
References
Integral Membrane Proteoglycans as Matrix Receptors: Role in Cytoskeleton and Matrix Assembly at the Epithelial Cell Surface
I. Introduction
II. Characteristics of Mammary Epithelial Cell Surface Proteoglycan
III. Distribution of Epithelial Cell Surface Proteoglycan
IV. Heparan Sulfate Proteoglycan Binds Stromal Matrix Components
V. Cell Surface Proteoglycan as a Matrix Anchor to the Cytoskeleton
VI. Cell Surface Proteoglycan is a Matrix Receptor
VII. Summary
References
Structural Organization of Proteoglycans in Cartilage
I. Introduction
II. Macromolecular Structure of Isolated Proteoglycans Based on Electron-Microscopic Analysis
III. Preservation Methods for Proteoglycans in Tissue
IV. Morphology of Proteoglycans in Cartilage
V. Spatial Arrangement of Proteoglycans in Native Tissue
References
Proteoglycans, Chondrocalcin, and the Calcification of Cartilage Matrix in Endochondrial Ossification
I. Anatomical Organization of the Growth Plate
II. Composition and Organization of the Cartilage Matrix of Growth Plate
III. Changes in the Proteoglycans of the Growth Plate Associated with Calcification
IV. Purified Proteoglycans and Glycosaminoglycans Can Bind Calcium and Inhibit Calcification In Vitro
V. A Unifying Hypothesis to Explain the Proteoglycan Changes That May Occur in Calcifying Growth Plate Cartilage
References
Biochemical Basis of Age-Related Changes in Proteoglycans
I. Introduction
II. Aging and Maturation
III. Proteoglycan Populations: Age-Related Changes
IV. Biosynthesis
V. Proteoglycans in Disease
References
Extracellular Matrix Components of the Synapse
I. Introduction
II. ECM Components are Involved in Synaptic Regeneration
III. Axonal Transport of Sulfated Materials
IV. Proteoglycans in Secretory Vesicles
V. A Synaptic Junctional Proteoglycan Related to the Vesicle Form
VI. Purification and Characterization of the ECM Proteoglycan
VII. The Antigenic Determinant of Electric Organ TAP
VIII. Insertion of the Anchorage Protein
IX. Other Components of the ECM at the Synapse
References
Blood Vessel Proteoglycans
I. Introduction
II. Biochemistry of Arterial Proteoglycans
III. Morphology of Arterial Proteoglycans
IV. Proteoglycans in Atherosclerosis
V. Cell Culture Studies
VI. Concluding Remarks
References
Heparan Sulfate Species and Blood Vessel Wall Function
I. Introduction
II. The Role of Heparan Sulfate Species as a Regulator of Coagulation Mechanism Activity
III. Role of Heparan Sulfate as a Modulator of Smooth Muscle Proliferation
References
Cell-Associated Proteoglycans in Human Malignant Melanoma
I. Extracellular Matrix Composition during Tumorigenesis
II. Chondroitin Sulfate Proteoglycans Synthesized by Human Melanoma Cells: Production of Monoclonal Antibodies
III. Biosynthesis and Intracellular Transport of Proteoglycans
IV. Conclusion
References
Intracellular Proteoglycans in Cells of the Immune System
I. Introduction
II. Localization and Characterization of Secretory Granule Proteoglycans in Different Cell Types
III. Speculated Functions of Intracellular Proteoglycans in Immunity and Inflammation
IV. Summary
References
Index
「Nielsen BookData」 より