Mechanisms of cytotoxicity by NK cells

著者

    • Herberman, Ronald B.
    • Callewaert, Denis M.
    • International Workshop on NK Cells

書誌事項

Mechanisms of cytotoxicity by NK cells

edited by Ronald B. Herberman, Denis M. Callewaert

Academic Press, 1985

タイトル別名

Mechanisms of cytotoxicity by natural killer cells

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注記

Based on the Third International Workshop on NK Cells held at Meadow Brook Hall, Oakland University, Rochester, Mich., in May 198

Includes bibliographies and index

内容説明・目次

内容説明

Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their activity. The text is further divided into five major sections according to the sequence of the workshop sessions. A separate chapter from the sections has been included at the beginning of the book. The introductory chapter clarifies some points in the subject area of NK cells, particularly its definition. The heterogeneity of NK cells is also discussed in this chapter. Then, the book presents the major topics, including the purification and characterization of NK cells and NK target structures and recognition sites. The mechanisms of postrecognition interactions between NK cells and targets; regulation of NK activity and NK cells; and cultured cells with NK-like activity are also discussed. This book will serve as a helpful guide to students and professionals (scientists, researchers, and professors) in the fields of immunology, biology, microbiology, biochemistry, among others.

目次

Contributors Preface I Purification and Characterization of NK Cells Purification and Characterization of NK Cells Surface Phenotype and Functions of Human Natural Killer Cells Characteristics of Mouse NK Cells and Their Precursors Enrichment Methodology for Murine NK Activity II Characterization of NK Target Structures and Recognition Sites on NK Cells Molecular Characterization of NK Target Antigens and Target Recognition Sites on NK Cells Analysis of NK Target Structures. K562 Membrane Components Associated with Susceptibility to NK Attack Role of Target Histocompatibility Antigens in Regulation of Natural Killer Activity: A Reevaluation and a Hypothesis Role of NK Cells in Hybrid Resistance to Bone Marrow Grafts Evidence That Natural Killer Cells Are Pre-Thymic T Cells with Receptors for Self and Non-Self H Antigens Receptors for "Self" Recognition Shared by Human T Lymphocytes and NK Cells Analysis of NK Activity against Virus-Infected Target Cells III Mechanisms of Postrecognition Interactions between NK Cells and Targets Biochemistry of NK Cytotoxicity NK-Target Cell Interactions in Binding, Triggering, Programming, and Lethal Hit Stages of NK Cytotoxicity NK Mediated Cell Lysis: A Directed Secretory Event of Cytolytic Tubular Structures Involvement of the Cytoskeleton and an Associated 95 KD Protein in Recognition and Lysis by NK Cells Ultrastructural Analysis of Human Natural Killer Cell-Target Cell Interactions Leading to Target Cell Lysis Role of Proteases in NK Activity Enzymes Involved in Natural Killer Cell Activity: Evidence for Phospholipases, Lipoxygensases, and Serine Dependent Proteinases The Role of Phospholipid Methylation and Chromosomally Regulated Target Structures in Pre- and Post-Recognition Events in the NK Cytolytic Pathway Monosaccharide Concentration Dependent Inhibition of Human Natural Cytotoxicity The Potential Role of Arachidonic Acid Metabolism in Human Natural Killer Cell Activity The Role of the Lipoxygenase in Regulation of NK Activity No Confirmed Role for Reactive Oxygen Intermediates in Natural Killer (NK) Cell-Mediated Cytolysis Oxidative Burst Does Not Mediate Human Monocyte Tumoricidal Activity The Role of Cytoplasmic Granules in NK Cell Cytotoxicity Functional and Biochemical Characterization of Natural Killer Cytotoxic Factors and Their Role in the NK Lytic Mechanism Characteristics of Human Natural Killer Cytotoxic Factor (NKCF) Lysis and Possible Relationship to Lysis by NK Cells Role of Soluble Lytic Factors in NK Activity Cytotoxic Factors from Marmoset Monkey NK-Like Cell Lines IV Regulation of NK Activity and Regulation by NK Cells Regulation of NK Cells Kinetic Models for Natural Cytotoxicity and Their Use for Studying Activated NK Cells Augmentation of Natural Killer Cell Activity by Recombinant Interleukin-2 and Recombinant Interferons Lymphokines Involved in the Generation and Regulation of NK and NC Cells Regulation of Mouse NK Activity Alterations in Numbers of LGLs as Important Component of Regulation of NK Activity Effects of Phorbol Esters on NK Activity Characterization of Soluble Suppressor Factors Produced by Unstimulated Normal Human Lymphocytes Role of Transferrin and Transferrin-Related Proteins in Regulation of NK Activity in Vitro Effect of UVR and Membrane Fluidity on NK Cytotoxic Activity Immunoregulatory Effects of NK Cells Regulation of the B Cell Response by NK Cells Defective NK Cell Mechanism in Patients with Leukemia Characterization of NK Cells in Patients with Chronic Myelogenous Leukemia Natural Killer Cell Activity in Genetic Diseases V Cultured Cells with NK-Like Activity: Models for Analysis of NK Activity NK Clones: Isolation and Characterizations K562 Tumor Cells Preferentially Activate Leu 11 + Human Large Granular Lymphocytes in a Mixed Lymphocyte Response Culture Discrimination between Anomolous Killer Cells and NK-Like Cells Differentiation of Large Granular Lymphocytes during Induction of Activated Killer Cells in Vitro Patterns of Proliferation in Human NK Cells: Practical and Theoretical Implications Culture of NK Cells: Specificity, Phenotypes, Functions, and Comparison with Activated T Cells Analysis and Functional Characterization of T3-, NK Cell Derived and T3+, CTL Precursor Cell Derived Clones NK Cells and T Cell Differentiation Recognitive Heterogeneity of NK Cells Index

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