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[Pt. A] ISBN 9780121820053
内容説明
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
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Pt. C ISBN 9780121821340
内容説明
Since biological tissues are unstable in an oxygen atmosphere, a great deal of effort is expended by organisms to metabolically limit or repair oxidative tissue damage. This volume of Methods in Enzymology and its companion Volume 234 present methods developed to investigate the roles of oxygen radicals and antioxidants in disease.
目次
Generation, Detection, and Characterization of Oxygen Radicals in Chemistry, Biochemistry, and Intermediate States of Reduction:C. von Sonntag and H.-P. Schuchmann, Pulse Radiolysis.M. Saran and W. Bors, Pulse Radiolysis for Investigation of Nitric Oxide-Related Reactions.M. D'Aquino, C. Bullion, M. Chopra, D. Devi, S. Devi, C. Dunster, G. James, E. Komuro, E. Niki, F. Raza, F. Robertson, J. Sharma, and R. Willson, Sulfhydryl Free Radical Formation by Sonolysis, by Radiolysis, and Thermally: Vitamin A, Curcumin, Muconic Acid, and Related Conjugated Olefins and References.C. von Sonntag and H.-P. Schuchmann, Suppression of Hydroxyl Radical Reactions in Biological Systems: Considerations Based on Competition Kinetics.O.I Aruoma, Deoxyribose Assay for Detecting Hydroxyl Radicals.H. Kaur and B. Halliwell, Detection of Hydroxyl Radicals by Aromatic Hydroxylation.P.J. Evans and B. Halliwell, Measurement of Iron and Copper in Biological Systems: Blemycin and Copper-Phenanthroline Assays.L.M. Weiner, Oxygen Radicals Generation and DNA Scission by Anticancer and Synthetic Quinones.G.M. Rosen, S. Pou, B.E. Britigan, and M.S. Cohen, Spin Trapping of Hydroxyl Radicals in Biological Systems.R.P. Mason and K.T. Knecht, In Vivo Detection of Radical Adducts by Electron Spin Resonance.E. Albano, A. Tomasi, and M. Ingelman-Sundberg, Spin Trapping of Alcohol-Derived Radicals in Microsomes and Reconstituted Systemsby Electron Spin Resonance.M. Tsuchiya, M. Suematsu, and H. Suzuki, In Vivo Visualization of Oxygen Radical-Dependent Photoemission.J. Fuchs, N. Groth, T. Herrling, and L. Packer, In Vivo Electron Paramagnetic Resonance Imaging of Skin.A. Mori, X. Wang, and J. Liu, Electron Spin Resonance Assay of Ascorbate-Free Radicals in Vivo.N. Gotoh and E. Niki, Measurement of Superoxide Reaction by Chemiluminescence.Isolation, Characterization, and Assay of Enzymes or Substances Involved in Formation or Removal of Oxygen Radicals:J.D. Morrow and L.J. Roberts, II, Mass Spectrometry of Prostanoids: F2-Isoprostances Produced by NonCyclooxygenase Free Radical-Catalyzed Mechanism.R. Cueto, G.L. Squadrito, and W.A. Pryor, Quantifying Aldehydes and Distinguishing Aldehydic Product Profiles from Autooxidation and Ozonation of Unsaturated Fatty Acids.S.P. Wolff, Ferrous Ion Oxidation in Presence of Ferric Ion Indicator Xylenol Orange for Measurement of Hydroperoxides.C. Giulivi and E. Cadenas, Ferrylmyoglobin Formation: Chemical Reactivity Toward Electron-Donating Compounds.A. Roveri, M. Maiorino, and F. Ursini, Enzymatic and Immunological Measurements of Soluable and Membrane-Bound Phospholipid-Hydroperoxide Glutathione Peroxidase. M. Inoue, Targeting Superoxide Dismutase by Gene and Protein Engineering.O.T.G. Jones and J.T.Hancock, Assays of Plasma and Membrane NADPH Oxidase.J.S. Beckman, J. Chen, H. Ischiropoulos, and J.P. Crow, Oxidative Chemistry of Peroxynitrite.M.E. Murphy and E. Noack, Nitric Oxide Assay Using Hemoglobin Method.J.M. Hevel and M.A.Marletta, Nitric-Oxide Synthase Assays.U. Firstermann, J.S. Pollock, W.R. Tracey, and M. Nakane, Isoforms of Nitric-Oxide Synthase: Purification and Regulation.C.J. Lowenstein and S.H Snyder, Purification, Cloning, and Expression of Nitric-Oxide Synthase.Methods for Assessing Molecular, Cell, and Tissue Damage: Assay and Repair of Oxidative Damage:G. van Ginkel and A. Sevanian, Lipid Peroxidation-Induced Membrane Structural Alterations.W. Jessup, R.T. Dean, and J.M. Gebicki, Iodometric Determination of Hydroperoxides in Lipids and Proteins.F.P. Corongiu and S. Banni, Detection of Conjugated Dienes by Second Derivative Ultraviolet Spectrophotometry.O. Sergent, P. Cillard, and J. Cillard, Ultraviolet and Infraed Methods for Analysis of Fatty Acyl Esters in Cellular Systems.S. Chirico, High-Performance Liquid Chromatography-Based Thiobarbituric Acid Tests.Y. Yamamoto, Chemiluminescence-Based High-Performance Liquid Chromatography Assay of Lipid Hydroperoxides.T. Miyazawa, K. Fujimoto, T. Suzuki, and K. Yasuda, Determination of Phospholipid Hydroperoxides using Luminol Chemiluminescence-High-Performance Liquid Chromatography.G.A.S. Ansari and L.L. Smith, Assay of Cholesterol Autoxidation.H. Shimaski, Fluorescent Lipid Peroxidation Products.R.L. Levine, J.A. Williams. E.R. Stadtman, and E. Shacter, Carbonyl Assays for Determination of Oxidatively Modified Proteins.A.Z. Reznick and L. Packer, Oxidative Damage to Proteins: Spectrophotometric Method for Carbonyl Assay.C. Giulivi and K.J.A. Davies, Dityrosine: A Marker for Oxidatively Modified Proteins and Selective Proteolysis.K. Uchida and E.E. Stadtman, Quantitation of 4-Hydroxynonenal Protein Adducts.M.-L. Hu, Measurement of Protein Thiol Groups and Glutathione in Plasma.J.A. Thomas, Y.-C. Chai, and C.-H. Jung, Protein S-Thiolation and Dethiolation.E. Kalef and C. Gitler, Purification of Vicinal Dithiol-Containing Proteins by Arsenical-Based Affinity Chromatography.C. Gitler, M. Mogyoros, and E. Kalef, Labeling of Protein Vicinal Dithiols: Role of Protein-S2 to Protein-(SH)2 Conversion in Metabolic Regulation and Oxidative Stress.T.P.M. Akerboom and H. Sies, Transport of Glutathione Disulfide and Glutathione S-Conjugates in Hepatocyte Plasma Membrane Vesicles.H. Puhl, G. Waeg, and H. Esterbauer, Methods to Determine Oxidation of Low Density Lypoproteins.D. Bonnefont-Rousselot, M. Gardes-Albert, J. Delattre, and C. Ferradini, Quantitative Low Density Lipoprotein Oxidation by Gamma Radiolysis. B. Arrio, M. Arrio, D. Bonnefont-Rousselot, J.D. Catudioc, and L. Packer, Assaying Low Density Lipoprotein by Laser Light Scattering.N. Doussett. G.Ferretti, M. Taus. P. Valdiguig, and G. Curatola, Fluorescence Analysis of Lipoprotein Peroxidation.W. Sattler, D. Mohr, and R. Stocker, Lipoprotein Isolation and Peroxidation: High-Performance Liquid Chromatography Postcolumn Chemiluminescence.N. Noguchi and E. Niki, Apolipoprotein B Protein Oxidation in Low Density Lipoproteins.M. Nakano and S. Koga, Luciferin Derivative for Assay of Myeloperoxidase and Dopamine Metabolism.A.J. Kettle and C.C. Winterbourn, Chlorination Activity of Myeloperosidase.J. Jahngen-Hodge, A. Taylor, F. Shang, L.L. Huang, and C. Mura, Oxidative Stress to Lens Crystallins.K.P. Mitton and J.R. Trevithick, High-Performance Liquid Chromatography-Electrochemical Detection of Antioxidantsin Vertebrate Lens: Glutathione, Tocopherol, and Ascorbate.G. Rothe and G. Valet, Flow Cytometric Assays of Oxidative Burst Activity in Phagocytes.W. Seeger, D. Walmrath, F. Grimminger, S. Rosseau, H. Schatte, H.-J. Kramer, L. Ermert, and L. Kiss, Acute Respiratory Distress Syndrome: Model Systems using Isolated Perfused Rabbit Lung. C.S. Lieber and L.M. DeCarli, Animal Models of Chronic Ethanol Toxicity.W. Drige, H.P. Eck, and S. Mihm, Oxidant-Antioxidant Status in Human Immunodeficiency Virus Infection.D.K. Das and N. Maulik, Antioxidant Effectiveness in Ischemia-Reperfusion Tissue Injury.V. Ravindranath, Animal Models and Molecular Markers for Cerebral Ischemia-Reperfusion Injury in Brain.C.F. Babbs, Histochemical Methods for Localization of Endothelial Superoxide and Hydrogen Peroxide Generation in Perfused Organs.D.K. Bhuyan and K.C. Bhuyan, Assessment of Oxidative Stress to the Eye in an Animal Model for Cataract.Index.
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Pt. D ISBN 9780121821357
内容説明
Since biological tissues are unstable in an oxygen atmosphere, a great deal of effort is expended by organisms to metabolically limit or repair oxidative tissue damage. This volume of Methods in Enzymology and its companion Volume 233 present methods developed to investigate the roles of oxygen radicals and antioxidants in disease. It includes techniques and assays of the activity of biothiols in soluble systems, their interaction with lipids and proteins, and the various new thiol enzymes, such as thioltransferases, being elucidated. Antioxidant reactions and gene regulation are also included.
目次
Oxidative Damage to DNA and DNA Repair:
M. Dizdaroglu, Chemical Determination of Oxidative DNA Damage by Gas Chromatography-Mass Spectrometry.
M.K. Shigenaga, E.N. Aboujaoude, Q. Chen, and B.N. Ames, Assays of the Oxidative DNA Damage Biomarker 8-Oxo-2-deoxyguanosine and 8-Oxoguanine in Nuclear DNA and Biological Fluids by High-Performance Liquid Chromatography with Electrochemical Detection.
K.K. Hamilton, K. Lee, and P.W. Doetsch, Detection and Characterization of Eukaryotic Enzymes That Recognize Oxidative DNA Damage.
W.A. Schulz, M.S.W. Obendorf, and H. Sies, Localization of Strand Breaks in Plasmid DNA Treated with Reactive Oxygen Species.
Y. Luo, E.S. Henle, R. Chatopadhyaya, R. Jin, and S. Linn, Detecting DNA Damage Caused by Iron and Hydrogen Peroxide.
P.K. Wong and R.A. Floyd, Photochemical Synthesis of 8-Hydroxyguanine Nucleosides.
M.J. Burkitt, Copper (DNA Adducts).
J. Cadet. J.-L. Ravanat, G.W. Buchko, H.C. Yeo, and B.N. Ames, Singlet Oxygen DNA Damage: Chromatographic and Mass Spectrometric Analysis of Damage Products.
C. Baumstark-Khan, Alkaline Elution versus Fluorescence Analysis of DNA Unwinding.
L. Augeri, K.K. Hamilton, A.M. Martin, P. Yohannes, and P.W. Doetsch, Purification and Properties of Yeast Redoxyendonuclease.
C.F.M. Menck, Shuttle Vector between Prokaryotes and Eukaryotes for Assaying Singlet Oxygen-Induced DNA Damage and Mutagenicity.
B. Epe and J. Hegler, Oxidative DNA Damage: Endonuclease Fingerprinting.
Assay of Stress Genes/Proteins, Effects of Reactive Oxygen Species and Antioxidants on Cell Regulatory Processes:
W. Drige, S. Mihm, M. Bockstette, and S. Roth, Effect of Reactive Oxygen Intermediates and Antioxidants on Proliferation and Function of T Lymphocytes.
R. Schreck and P.A. Baeuerle, Assessing Oxygen Radicals as Mediators in Activation of Inducible Eukaryotic Transcription Factor NF-(B.
S. Xanthoudakis and T. Curran, Analysis of c-Fos and c-Jun Redox-Dependent DNA Binding Activity.
D.R. Crawford, C.A. Edbauer-Nechaman, C.V. Lowry, S.L. Salmon, Y.K. Kim, J.M.S. Davies, and K.J.A. Davies, Assessing Gene Expression during Oxidative Stress.
G. Storz and S. Altuvia, OxyR Regulon.
R.M. Tyrrell and S. Basu-Modak, Transient Enhancement of Heme Oxygenase 1 mRNA Accumulation: A Marker of Oxidative Stress to Eukaryotic Cells.
J.S. Bertram and L.-X. Zhang, Assays for Regulation of Gap Junctional Communication and Connexin Expression by Carotenoids.
G.H.W. Wong and D.V. Goeddel, One-Day Northern Blotting for Detection of mRNA: NDGA Inhibits the Induction of Mn-SOD mRNA by Agonists of Type 1 Receptor.
C.E. Cross and B. Halliwell, Evaluation of Biomolecular Damage by Ozone.
B.K. Tarkington, T.R. Duvall, and J.A. Last, Ozone Exposure of Cultured Cells and Tissues.
Antioxidant Identification, Characterization, and Assay: A. Total Antioxidant Status:
P.A. Motchnik, B. Frei, and B.N. Ames, Measurementof Antioxidants in Human Blood Plasma.
C. Rice-Evans and N.J. Miller, Total Antioxidant Status in Plasma and Body Fluids.
B. Natural Source Antioxidants: Vitamin E:
W. Schaep and R. Rettenmaier, Analysis of Vitamin E Homologs in Plasma and Tissue: High-Performance Liquid Chromatography.
G. Riss, A.W. Kormann, E. Glinz, W. Walther, and U.B. Ranalder, Separation of the Eight Stereoisomers of all-rac-(-Tocopherol from Tissues and Plasma: Chiral Phase High-Performance Liquid Chromatography and Capillary Gas Chromatography.
D.C. Liebler, Tocopherone and Epoxytocopherone Products of Vitamin E Oxidation.
V.E. Kagan and L. Packer, Light-Induced Generation of Vitamin E Radicals: Assessing Vitamin E Regeneration.
M. Yamaoka and K. Komiyama, Antioxidative Activity of Tocotrienol in Heterogeneous System: Indication of Restriction within Membrane by Fluorescence Measurement.
G.T. Vatassery, Determination of Tocopherols and Tocopherolquinone in Human Red Blood Cell and Platelet Samples.
Vitamin C:
G. Barja and A. Hernanz, Vitamin C, Dehydroascorbate, and Uric Acid in Tissues and Serum: High-Performance Liquid Chromatography.
M. Inoue and K. Koyama, In Vivo Determination of Superoxide and Vitamin CRadicals Using Cytochrome c and Superoxide Dismutase Derivatives.
Quinones:
V.E. Kagan, E.A. Serbinova, D.A. Stoyanovsky, S. Khwaja, and L. Packer, Assay of Ubiquinones and Ubiquinols as Antioxidants.
E.A. Serbinova and L. Packer, Antioxidant Properties of (-Tocopherol and (-Tocotrienol.
Glutathione:
M. Asensi, J. Sastre, F.V. Pallardo, J.M. Estrela, and J. Vita, Determination of Oxidized Glutathione in Blood: High Performance Lipid Chromatography.
Carotenoids and Vitamin A:
M. Tsuchiya, V.E. Kagan, H.-J. Freisleben, M. Manabe, and L. Packer, Antioxidant Activity of (-Tocopherol, (-Carotene, and Ubiquinol in Membranes: cis-Parinaric Acid-Incorporated Liposomes.
A.R. Sundquist, K. Briviba, and H. Sies, Singlet Oxygen Quenching by Carotenoids.
W. Stahl and H. Sies, Separation of Geometrical Isomers of (-Carotene and Lycopene.
M.A. Livrea and L. Tesoriere, Lipoperoxyl Radical-Scavenging Activity of Vitamin A and Analogs in Homogeneous Solution.
Flavonoids:
D.K. Das, Overview of Naturally Occurring Flavonoids: Structure, Chemistry, and High Performance Lipid Chromatography Methods for Separation and Characterization.
W. Bors, C. Michel, and M. Saran, Flavonoid Antioxidants: Rate Constants for Reactions with Oxygen Radicals.
A.E. Hagerman and L.G. Butler, Assay of Condensed Tannins or Flavonoid Oligomers and Related Flavonoids in Plants.
I. Morel, G. Lescoat, P. Cillard, and J. Cillard, Role of Flavonoids andIron Chelation in Antioxidant Action.
J.R.S. Hoult, M.A. Moroney, and M. Paya, Actions of Flavonoids and Coumarins on Lipoxygenase and Cyclooxygenase.
(-Lipoic Acid:
Y.J. Suzuki, M. Tsuchiya, and L. Packer, Determination of Structure-Antioxidant Activity Relationships of Dihydrolipoic Acid.
Extracts from Natural Products:
L. Marcocci, L. Packer, M.-T. Droy-Lefaix, A. Sekaki, and M. Gardos-Albert, Antioxidant Action of Ginkgo biloba Extract EGb 761.
C. Synthetic Antioxidants: Drugs:
H. Sies, Ebselen: A Glutathione Peroxidase Mimic.
P. Moldeus and I.A Cotgreave, N-Acetylcysteine.
M.E. Anderson, E.J. Levy, and A. Meister, Preparation and Use of Glutathione Monoesters.
E.J. Levy, M.E. Anderson, and A. Meister, Preparation and Properties of Glutathione Diethyl Ester and Related Derivatives.
S.J.T. Mao, M.T. Yates, and R.L. Jackson, Antioxidant Activity and Serum Levels of Probucol and Probucol Metabolites.
D.M. Lee, (-Phenyl N-tert-Butylnitrone as Antioxidant for Low Density Lipoproteins.
J.M. Carney and R.A. Floyd, Brain Antioxidant Activity of Spin Traps in Mongolian Gerbils.
L. Marcocci, Y.J. Suzuki, M. Tsuchiya, and L. Packer, Antioxidant Activity of Nitecapone and Its Analog OR-1246: Effect of Structural Modification on Antioxidant Action.
M. Miki, Penicillamine as Antioxidant.
E.D. Hall and J.M. McCall, Antioxidant Action of Lazaroids.
A.M. Miles and M.B. Grisham, Antioxidant Properties of Aminosalicylates.
L. Horakova, H. Sies, and S. Steenken, Antioxidant Action of Stobadine.
M.C. Krishna and A. Samuni, Nitroxides as Antioxidants.
H. Wiseman, Tamoxifen and Estrogens as Membrane Antioxidants: Comparison with Cholesterol.
O.H. Morand, Reactivity of Plasmalogens to Singlet Oxygen and Radicals.
I.T. Mak and W.B. Weglicki, Antioxidant Activity of Calcium Channel Blocking Drugs.
T.G. Gantchev, J.E. van Lier, D.A. Stoyanovsky, J.C. Yalowich, and V.E. Kagan, Interactions of the Phenoxyl Radical of Antitumor Drug, Etoposide, with Reductants in Solution and in Cell and Nuclear Homogenates: Electron Spin Resonance and High-Performance Liquid Chromatography.
Author Index.
Subject Index.
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