- Volume
-
pt. 1 ISBN 9780120442751
Description
The Retina: A Model for Cell Biology Studies, Part I, is the first of a two-part series that details developments in the study of retinal cell biology. The book begins with some basic information about retinal structure and development followed by a discussion of the advantages of the retina as a model system for cell biology studies. It reviews some of the major events in the maturation of the retina pertinent to the assembly of neuronal circuits. The book describes studies of neuronal assembly in order to demonstrate that adhesion-based neuronal assembly may be the most elaborated example of a wider class of morphogenetic phenomena categorized as ""adhesion-guided multicellular assembly"" systems. The remaining chapters discuss in vivo and in vitro studies on trophic interactions in retinal development and in retinal degenerations; cell motility in the retina; molecular properties of vertebrate rod cells; the role of cyclic nucleotides in the metabolism and function of the retina; and the cellular and molecular aspects of photosensitive membrane turnover.
Table of Contents
Contributors
Preface
Issues and Questions in Cell Biology of the Retina
I. Introduction
II. The Adult Retina
III. The Developing Retina
IV. The Pathological Retina
V. Concluding Remark
References
The Development of Retinal Networks
I. Introduction
II. The Development of Retinal Layers
III. Neurochemical Differentiation in the Retina
IV. Maturation of Retinal Networks
V. Summary
References
Differential Adhesion in Neuronal Development
I. Introduction
II. Neuronal Guidance Systems: Biological Studies
III. Molecular Mechanisms of Adhesion
IV. Neuronal Recognition and Differential Adhesion
References
Trophic Interactions in Retinal Development and In Retinal Degenerations. In Vivo and In Vitro Studies
I. Introduction
II. The Regulation of Neuronal Survival
III. The Search for "Trophic" and Other Regulatory Factors
IV. The Search for Molecules Controlling Survival and Differentiation of Retinal Neurons: In Vitro Studies
V. Concluding Remarks
References
Cell Motility in the Retina
I. Introduction
II. The Structural Machinery: The Cytoskeleton
III. Force-Producing Mechanisms
IV. Vertebrate Retinomotor Movements
V. Invertebrate Retinomotor Movements
VI. Cytoskeleton and Motility in RPE Cells
VII. Morphological Aspects of Retinal Synaptic Modulation
VIII. Alignment of Photoreceptors
IX. Concluding Remarks
References
Molecular Dynamics of the Rod Cell
I. Structure of the Rod Cell
II. Disk Membrane of the Rod Cell Outer Segment
III. Rhodopsin: The Photoreceptor Protein
IV. Light-Dependent Biochemistry of the Rod Cell
References
Cyclic Nucleotides in Retinal Function and Degeneration
I. Introduction
II. Cyclic Nucleotide Metabolism in Rod-Dominant Retinas
III. Cyclic Nucleotides in Cone-Dominant Retinas
IV. Abnormalities in Cyclic Nucleotide Metabolism in Retinal Degenerations
V. Future Prospects
References
Photosensitive Membrane Turnover: Differentiated Membrane Domains and Cell-Cell Interaction
I. Introduction
II. Synthesis and Assembly of Photosensitive Membrane
III. Disk Shedding and Phagocytosis
IV. Regulation of Membrane Turnover
V. Summary
References
Index
- Volume
-
pt. 2 ISBN 9780120442768
Description
The Retina: A Model for Cell Biology Studies, Part II, is the second of a two-part series that details developments in the study of retinal cell biology. The book begins with a review of the current evidence for the role of putative neurotransmitters at particular synapses in the retina. It then discusses pre- and postsynaptic regulatory mechanisms; the interactions of neurotransmitter-neuromodulatory systems; and cellular effects of putative neurotransmitters and neuromodulators. This is followed by an introduction to vision psychophysics, showing its application in studying the functioning of cells in the retina. The remaining chapters discuss how the retinal pigment epithelium cell might be used as a model for studying biological problems of current interest; extracellular matrix molecules; concepts and controversies regarding the biology of endothelial cells, the key elements in the phenomenon of intraocular neovascularization; the use of genetic mutations and genetic mosaics for the study of the retina; and the retina as a regenerating organ.
Table of Contents
Contributors
Preface
Neurotransmitters and Neuromodulators in the Retina: Regulation, Interactions, and Cellular Effects
I. Introduction
II. Putative Neurotransmitters and Neuromodulators of Retinal Neurons
III. Pre- and Postsynaptic Regulatory Mechanisms
IV. Interactions of Neurotransmitters and Neuromodulators
V. Cellular and Morphological Effects of Neurotransmitters and Neuromodulators
VI. Concluding Remarks
References
Vision Psychophysics and Retinal Cell Biology
I. Introduction
II. The Systems Approach of Psychophysics
III. Psychophysical Studies of Photoreceptor Physiology
IV. Psychophysical Studies of Abnormal Retinal Physiology in Retinitis Pigmentosa
V. Retinal Cell Biology from a Psychophysicist's Perspective
References
The Cell Biology of the Retinal Pigment Epithelium
I. Summary of RPE Cell Structure and Functions
II. Cellular Processes That Have Been Studied in the RPE
III. Use of Cultured RPE Cells to Study Cellular Processes
IV. Summary and Future Research
References
Extracellular Matrix Molecules: Their Importance in the Structure and Function of the Retina
I. Introduction
II. Extracellular Matrices
III. Retinal Extracellular Matrices
IV. Effects of Extracellular Matrix Molecules on Retinal Neurons
V. Concluding Comments
References
Cell Biology and Biochemistry of Endothelial Cells and the Phenomenon of Intraocular Neovascularization
I. Introduction
II. New Vessels from Preexisting Vessels
III. Steps in Capillary Formation
IV. Maturation of the Vascular Bed
V. Factors Influencing Capillary Sprout Formation
VI. Conclusion
References
Genetic Mosaics as Tolls for the Study of the Retina
I. A Modest Catalog of Known Mutations Affecting the Eye
II. Genetic Mosaics: A Primer
III. The Study of the Site of Gene Action
IV. The Study of Cell Lineage
V. The Study of Embryonic Retinal Development
VI. General Conclusions
References
The Retina as a Regenerating Organ
I. Introduction
II. Characteristics of Regenerating Goldfish Retinal Ganglion Cells
III. Conditions That Modify Axonal Outgrowth
IV. Regulation of the Cell Body Reaction
V. General Conclusions
References
Index
by "Nielsen BookData"