Growth factors in biology and medicine
著者
書誌事項
Growth factors in biology and medicine
（Ciba Foundation symposium, 116）
Wiley, 1985
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注記
"Symposium on Growth Factors in Biology and Medicine, held at the Ciba Foundation, London, 22-24 January 1985. Editors: David Evered, Jonathan Nugent (organizer) and Julie Whelan"--P. v
Includes bibliography and index
内容説明・目次
内容説明
Growth factors in biology and medicine Ciba Foundation Symposium 116 Chairman: Sir Michael Stoker 1985 An important current theme in biomedical research is the regulation of growth and development at the molecular and cellular level. Linked to this is the search for a means of controlling proliferative diseases, especially cancer. In this symposium, key research workers discuss the relationship between growth factors, their specific cell surface receptors, the cellular and viral oncogenes, and mitogenesis. The part that growth factors may play in malignant transformation, atherosclerosis, embryonic development and normal and abnormal haemopoiesis is debated. The main factors considered here are epidermal growth factor, platelet-derived growth factor, the haemopoietic growth factors, and nerve growth factor (a non-mitogenic, neurotrophic factor). The emphasis of the symposium is on the molecular biology of growth factors and their receptors and the analysis of the intracellular events that follow receptor-ligand interaction.
Specific topics include the relationship of the EGF receptor to the v-erb-B transforming protein, the role of protein phosphorylation in growth control, receptors for phorbol ester tumour promoters and their putative endogenous ligands, and a newly described regulatory factor which both inhibits and stimulates cell growth. Other Ciba Foundation Symposia published by Pitman: No 113: Retinoids, differentiation and disease Chairman: M.B. Sporn 1985 ISBN 0 272 79813 4 No 114: Fibrosis Chairman: A.J. Bailey 1985 ISBN 0 272 79814 2 No 117: Photoperiodism, melatonin and the pineal Chairman: R.V. Short 1985 ISBN 0 272 79821 5 No 118: Biochemistry of macrophages Chairman: Z.A. Cohn 1985 ISBN 0 272 79822 3
目次
Symposium on Growth Factors in Biology and Medicine, held at the Ciba Foundation, London, 22 24 January 1985 The topic of this symposium was proposed by Professor Russell Ross Editors: David Evered, Jonathan Nugent (Organizers) and Julie Whelan Sir Michael Stoker Introduction J. K. Heath and A. R. Rees Growth factors in mammalian embryogenesis Discussion Y. Yarden and J. Schlessinger The EGF receptor kinase: evidence for allosteric activation and intramolecular self-phosphorylation Discussion J. S. Huang and S. S. Huang Role of growth factors in oncogenesis: growth factor - proto-oncogene pathways of mitogenesis Discussion E. Rozengurt, A. Rodriguez-Pena and J. Sinnett-Smith Signalling mitogenesis in 3T3 cells: role of Ca2+-sensitive, phospholipid-dependent protein kinase Discussion M. Callahan, B. H. Cochran and C. D. Stiles The PDGF-inducible competence genes': intracellular mediators of the mitogenic response Discussion R. Ross, D. F. Bowen-Pope and E. W. Raines Platelet-derived growth factor: its potential roles in wound-healing, atherosclerosis, neoplasia, and growth and development Discussion H. Thoenen, S. Korsching, R. Heumann and A. Acheson Nerve growth factor Discussion T. M. Dexter, C. M. Heyworth and A. D. Whetton The role of haemopoietic cell growth factor (interleukin 3) in the development of haemopoietic cells Discussion A. W. Burgess Haemopoietic growth factors: structure and receptor interactions Discussion J. Zapf, E. Schoenle and E. R. Froesch In vivo effects of the insulin-like growth factors (IGFs) in the hypophysectomized rat: comparison with human growth hormone and the possible role of the specific IGF carrier proteins Discussion T. Hunter, C. B. Alexander and J. A. Cooper Protein phosphorylation and growth control Discussion P. M. Blumberg, K. L. Leach, B. Konig, A. Y. Jeng and N. A. Sharkey Receptors for the phorbol ester tumour promoters Discussion J. E. De Larco and D. A. Pigott Ectopic peptides released by a human melanoma cell line that modulate the transformed phenotype Discussion R. W. Holley, J. H. Baldwin, S. Greenfield and R. Armour A growth regulatory factor that can both inhibit and stimulate growth Discussion Final general discussion Receptor modulation and signalling systems Biological functions of growth factors Medical aspects of growth factors Index of contributors Subject index
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