Melanoma antigens and antibodies

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書誌事項

Melanoma antigens and antibodies

edited by Ralph A. Reisfeld and Soldano Ferrone

Plenum Press, c1982

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Includes bibliographies and index

内容説明・目次

内容説明

The ever-expanding research on human cancer has resulted in numerous technical and conceptual advances during the last few years. Serological, structural, and biological char- acterization of human melanoma constitutes one area of research that has received consid- erable attention from researchers and clinicians and has generated new and exciting infor- mation. In this volume, we have attempted to assemble work on topics that produced some of the most recent advances. We asked each author to describe and interpret his most cur- rent research and, whenever possible, to compare and contrast it with work of other inves- tigators in the field. We have been careful not to impose our viewpoints except in contri- butions from our own laboratories, since we want to provide the reader with as many divergent and sometimes opposing viewpoints as feasible. Therefore, we have not been overly concerned with overlaps in some individual topics. We hope that this volume will provide the reader with a well-balanced overview of current problems and ideas in a par- ticular area of cancer research. We wish to express our thanks to all contributors for their timely and very interesting manuscripts, and we sincerely hope that the reader will enjoy this volume and benefit as much from it as we did. R. A. Reisfeld S. Ferrone La Jolla ix Contents CHAPTER 1 Immunogenetics of Melanoma RONALD T. ACTON, CHARLES M. BALCH, BRUCE BUDOWLE, RODNEY C. P. Go, JEFFREY M. ROSEMAN, SENG-jAW SOONG, AND BRUCE O. BARGER 1. Introduction ...

目次

1 Immunogenetics of Melanoma.- 1. Introduction.- 2. Genetic Factors.- 3. An Immunogenetic Analysis of Melanoma Patients in Alabama.- 4. Implications and Future Direction.- References.- 2 Indomethacin, Prostaglandin, and Immune Regulation in Melanoma.- 1. Introduction.- 2. Prostaglandin and Indomethacin.- 3. Helper- and Suppressor-Cell Function in Tumor-Bearing Mice.- 4. Helper- and Suppressor-Cell Function in Cancer Patients.- 5. Mitogen Response in Melanoma Patients and Normal Subjects.- 6. Effects of Indomethacin on Mitogen Response.- 7. Correlation with Clinical Status of Melanoma Patients.- 8. Indomethacin Effects on Purified Lymphocytes and Monocytes.- 9. Are the Indomethacin Effects Related to Prostaglandin?.- 10. Summary.- References.- 3 Shedding and Degradation of Cell-Surface Macromolecules and Melanoma-Associated Antigens by Human Melanoma.- 1. Introduction.- 2. Release of Tumor Antigens.- 3. Degradation of Shed Tumor Antigens.- 4. Conclusion.- References.- 4 Monoclonal Antibodies as a Tool to Detect Melanoma-Associated Antigens.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- References.- 5 Tumor-Directed Cellular Immunity in Malignant Melanoma and the Antigens That Evoke It.- 1. Introduction.- 2. Studies Employing the Direct One-Stage Capillary Leukocyte Migration-Inhibition Technique.- 3. Clinical Stage and Tumor-Directed Cellular Immunity.- 4. Tumor-Directed Immunity during Tumor Regression.- 5. Effects of Treatment on Tumor-Directed Immunity.- 6. Correlation of Tumor-Directed Immunity and Histology.- 7. Formalinized Cell Suspensions as "Antigen" in One- and Two-Stage Leukocyte-Migration Assays.- 8. Reactions of Melanoma Patients' and Control Donors' Leukocytes with Fetal Materials.- 9. Reactions of Melanoma Patients' and Control Donors' Leukocytes with Materials from Nevi, Perimelanomatous Skin, Skin Involved by Lentigo Maligna, and Normal Skin.- 10. Indirect Leukocyte-Migration Assays.- 11. Concordance of Indirect and Direct Leukocyte-Migration Assays.- 12. Mechanism of Tumor-Cell-Induced Inhibition of Human Leukocyte Migration.- 13. Tissue-Cultured Lymphoblastoid Cells as Indicators of Lymphokine Generation.- References.- 6 Heterogeneity of Human Melanoma-Associated Antigens Revealed by Alloantisera and Xenoantisera.- 1. Introduction.- 2. Methodological Considerations.- 3. Human Antibodies to Melanoma.- 4. Nonhuman Primate Antibodies to Melanoma.- 5. Rabbit Antibodies to Melanoma.- 6. Monoclonal Antibodies to Melanoma.- 7. Factors That Affect Expression of Melanoma-Associated Antigens.- 8. Characterization of Melanoma-Associated Antigens.- 9. Clinical Implications of Melanoma Immunology.- 10. Summary.- References.- 7 Protein Antigens of Mouse Melanomas.- 1. Introduction.- 2. Xenogeneic Immunization.- 3. Absorption.- 4. Specificity Testing.- 5. Derivatization.- 6. Immune-Affinity Chromatography.- 7. Sodium Dodecyl Sulfate- Leukocytes with Materials from Nevi, Perimelanomatous Skin, Skin Involved by Lentigo Maligna, and Normal Skin.- 10. Indirect Leukocyte-Migration Assays.- 11. Concordance of Indirect and Direct Leukocyte-Migration Assays.- 12. Mechanism of Tumor-Cell-Induced Inhibition of Human Leukocyte Migration.- 13. Tissue-Cultured Lymphoblastoid Cells as Indicators of Lymphokine Generation.- References.- 6 Heterogeneity of Human Melanoma-Associated Antigens Revealed by Alloantisera and Xenoantisera.- 1. Introduction.- 2. Methodological Considerations.- 3. Human Antibodies to Melanoma.- 4. Nonhuman Primate Antibodies to Melanoma.- 5. Rabbit Antibodies to Melanoma.- 6. Monoclonal Antibodies to Melanoma.- 7. Factors That Affect Expression of Melanoma-Associated Antigens.- 8. Characterization of Melanoma-Associated Antigens.- 9. Clinical Implications of Melanoma Immunology.- 10. Summary.- References.- 7 Protein Antigens of Mouse Melanomas.- 1. Introduction.- 2. Xenogeneic Immunization.- 3. Absorption.- 4. Specificity Testing.- 5. Derivatization.- 6. Immune-Affinity Chromatography.- 7. Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis.- 8. Testing of Recovered Molecules.- 9. Discussion.- References.- 8 Clinical Significance of Tumor-Associated Antigens and Antitumor Antibodies in Human Malignant Melanoma.- 1. Introduction.- 2. Immune Response vs. Development of Malignancy.- 3. Recognition of Tumor-Assciated Antigens Expressed by Human Melanoma.- 4. Types of Tumor-Associated Antigens Expressed by Melanoma Cells.- 5. Significance of Melanoma Tumor-Associated Antigens Recognized by Allogeneic Antibody.- 6. Antibodies Bound in Vivo to Melanoma Cells.- 7. Isolation of Antitumor Antibodies by Affinity Chromatography.- 8. Melanoma Tumor-Associated Antigens in Spent Culture Medium.- 9. Development of Radioimmunoassay.- 10. Presence of Tumor-Associated Antigens in Urine of Melanoma Patients.- 11. Relationship of Serum Tumor-Associated Antigens and Immune Complexes with Inhibition of Lymphocyte Blastogenesis.- 12. Conclusions.- References.- 9 Specificity of Cell-Mediated Immunoreactivity in Melanoma and Comments on the Nature of Serum Blocking Factors.- 1. Introduction.- 2. Techniques of Cell-Mediated Immunity in Vitro.- 3. Specificity of Leukocyte-Adherence Inhibition.- 4. Some Current Concepts Concerning Tumor Antigens.- 5. Serum Blocking Factors.- 6. Conclusion.- References.- 10 Antigens in Human Melanomas Detected by Using Monoclonal Antibodies as Probes.- 1. Introduction.- 2. Methodology.- 3. Various Antigens Identified by Monoclonal Antibodies to Human Melanomas.- 4. Future Goals.- 5. Conclusions.- References.- 11 The Nature and Significance of Melanoma Antigens Recognized by Human Subjects.- 1. Introduction.- 2. Heterogeneity of Tumor-Associated Antigens Recognized by Human Subjects on Melanoma Cells.- 3. Nature of Melanoma Antigens Detected by Human Subjects.- 4. Tumor-Related Immune Responses to Melanoma Antigens.- 5. Biochemical Nature of Melanoma Antigens.- 6. Biological Significance of Melanoma Antigens.- 7. Summary Table.- 8. Conclusions.- References.- 12 Cellular and Humoral Studies of Malignant Melanoma.- 1. Work by Others.- 2. Work by Our Group.- References.- 13 Immunodiagnosis of Human Melanoma: Detection of Circulating Melanoma-Associated Antigens by Radioimmunoassay.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- References.- 14 The Association between Antigens of Human Malignant-Melanoma Cells and Mycobacterium bovis (BCG).- 1. Introduction.- 2. Shared Antigens between Mycobacterium bovis (BCG) and the Guinea Pig Line-10 Hepatocarcinoma.- 3. Shared Antigens between BCG and Human Malignant-Melanoma Cells.- 4. In vitro Immunization against Human Malignant-Melanoma Cells with Bacterial Extracts.- 5. Antibodies to Melanoma-Cell and BCG Antigens in Sera from Tumor-Free Individuals and from Melanoma Patients.- 6. Concluding Remarks.- References.- 15 Monoclonal Antibodies to Human Melanoma-Associated Antigens: Elicitation and Evaluation with Immunochemically Defined Antigen Preparations.- 1. Introduction.- 2. Elicitation of Tumor-Associated-Antigen-Specific Hybridomas with Immunochemically Defined Immunogens.- 3. Evaluation of Hybridomas with Solid-Phase, Immunochemically Defined Antigens.- 4. Characteristics of Monoclonal Antibodies Elicited and Selected with Immunochemically Defined Antigens.- 5. Conclusions.- References.- 16 The Significance of Circulating Immune Complexes in Patients with Malignant Melanoma.- 1. Introduction.- 2. Physicochemical Properties of Immune Complexes.- 3. Detection and Isolation of Immune Complexes.- 4. Dissociation and Separation of Immune-Complex Components.- 5. Analysis of Isolated Immune Complexes in Human Malignant Melanoma.- 6. Presence of Antiimmunoglobulin Complexes.- 7. Conclusions.- References.- 17 Molecular and Immunological Characterization of Human Melanoma-Associated Antigens.- 1. Introduction.- 2. Characterization of Antimelanoma Xenoantisera.- 3. Purification of Melanoma-Associated Antigens.- 4. Molecular Profile of Melanoma-Associated Antigens.- 5. Role of Carbohydrate in Shedding and Cell-Surface Expression of Melanoma-Associated Antigens.- 6. Functional Properties of 94K and 240K Melanoma-Associated Antigens.- 7. Conclusions.- References.- 18 Cell-Surface Structure and State of Malignancy in Human Malignant Melanoma.- 1. Introduction.- 2. Melanoma-Associated Antigens.- 3. Concluding Remarks.- References.- 19 Immunotherapy of Melanoma.- 1. Introduction.- 2. Malignant Melanoma.- 3. Bacillus Calmette Guerin.- 4. Levamisole.- 5. Transfer Factor.- 6. The Future.- 7. Summary.- References.- 20 Biological Studies of Antimelanoma Monoclonal Antibodies.- 1. Introduction.- 2. Monoclonal-Antibody-Defined Melanoma Antigens.- 3. Biological Functions of Monoclonal Antibodies.- References.- 21 The Features of Malignant Melanoma Organ-Specific Neoantigens Recognized by the Antitumor Immune Response of the Human Host.- 1. Introduction.- 2. Tube Leukocyte-Adherence-Inhibition Assay.- 3. Blocking Tube Leukocyte-Adherence-Inhibition Assay.- 4. Organ-Specific Neoantigens of Human Cancer.- 5. Summary.- References.- 22 Immunochemical Analysis of the Antigenic Profile of Human Melanoma Cells with Monoclonal Antibodies.- 1. Introduction.- 2. Expression of Histocompatibility Antigens on Human Melanoma Cells.- 3. Approach for Defining Tumor-Associated Antigens with Monoclonal Antibodies.- 4. Detection and Characterization of Melanoma-Associated Antigens Using Monoclonal Antibodies.- 5. Discussion.- 6. Perspective.- References.

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