The organic chemistry of drug synthesis

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書誌事項

The organic chemistry of drug synthesis

[edited by] Daniel Lednicer, Lester A. Mitscher ; with a glossary by Philip F. von Voigtlande

Wiley, 1977-

  • [Vol. 1]
  • Vol. 2
  • Vol. 3
  • Vol. 4
  • Vol. 5
  • Vol. 6
  • Vol. 7

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注記

"A Wiley-Interscience publication"

Includes index

内容説明・目次

巻冊次

Vol. 7 ISBN 9780470107508

内容説明

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

目次

Preface xi 1 Open-Chain Compounds 1 1. Peptidomimetic Compounds 2 A. Antiviral Protease Inhibitors 2 1. Human Immunodeficiency Virus 2 2. Human Rhinovirus 9 2. Miscellaneous Peptidomimetic Compounds 11 References 19 2 Alicyclic Compounds 21 1. Monocyclic Compounds 21 A. Prostaglandins 21 B. Antiviral Agents 25 C. Miscellaneous Monocyclic Compounds 29 2. Polycyclic Compounds: Steroids 31 A. 19-Nor Steroids 31 B. Corticosteroid Related Compounds 34 3. Polycyclic Compounds 38 References 40 3 Monocyclic Aromatic Compounds 43 1. Arylcarbonyl Derivatives 43 2. Biphenyls 47 3. Compounds Related to Aniline 50 4. Compounds Related to Arylsulfonic Acids 53 5. Diarylmethanes 58 6. Miscellaneous Monocyclic Aromatic Compounds 60 References 67 4 Carbocyclic Compounds Fused to a Benzene Ring 69 1. Indenes 69 2. Naphthalenes 73 3. Tetrahydronaphthalenes 74 4. Other benzofused carbocyclic compounds 79 References 81 5 Five-Membered Heterocycles 83 1. Compounds with One Heteroatom 83 2. Compounds with Two Heteroatoms 91 A. Oxazole and Isoxazoles 91 B. Imidazoles and a Pyrrazole 94 C. Thiazoles 99 D. Triazoles 103 E. Tetrazoles 109 References 112 6 Six-Membered Heterocycles 115 1. Compounds with One Heteroatom 115 A. Pyridines 115 B. Reduced Pyridines 117 C. Miscellaneous 119 2. Compounds with Two Heteroatoms 121 A. Pyrimidines 121 B. Miscellaneous Six-Membered Heterocycles 133 References 136 7 Five-Membered Heterocycles Fused to One Benzene Ring 139 1. Compounds with One Heteroatom 139 A. Benzofurans 139 B. Indoles 141 C. Indolones 148 D. Miscellaneous Compounds with One Heteroatom 153 2. Five-Membered Rings with Two Heterocyclic Atoms 156 A. Benzimidazoles 156 B. Miscellaneous Compounds 158 References 160 8 Six-Membered Heterocycles Fused to One Benzene Ring 163 1. Compounds with One Heteroatom 163 A. Benzopyrans 163 B. Quinolines and Their Derivatives 167 C. Quinolone Antibacterial Agents 172 2. Compounds with Two Heteroatoms 176 A. Benzoxazines 176 B. Quinazolines 178 C. Miscellaneous Benzo-Fused Heterocycles 184 References 186 9 Bicyclic Fused Heterocycles 189 1. Compounds with Five-Membered Rings Fused to Six-Membered Rings 189 A. Compounds with Two Heteroatoms 189 B. Compounds with Three Heteroatoms 191 C. Compounds with Four Heteroatoms 195 2. Compounds with Two Fused Six-Membered Rings 208 3. Miscellaneous Compounds with Two Fused Heterocyclic Rings: Beta Lactams 213 References 215 10 Polycyclic Fused Heterocycles 217 1. Compounds with Three Fused Rings 217 2. Compounds with Four Fused Rings 228 3. Compounds with Five or More Fused Rings: Camptothecins 230 References 232 Subject Index 233 Cross Index of Biological Activity 241 Cumulative Index 245
巻冊次

Vol. 2 ISBN 9780471043928

内容説明

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

目次

Monocyclic and Acyclic Aliphatic Compounds. Derivatives of Benzyl and Benzhydryl Alcohols and Amines. Phenylethyl and Phenylpropylamines. Arylalkanoic Acids and Their Derivatives. Monocyclic Aromatic Compounds. Steroids. Polycyclic Aromatic and Hydro-aromatic Compounds. Five-Membered Heterocycles. Six-Membered Heterocycles. Morphinoids. Five-Membered Heterocycles Fused to One Benzene Ring. Six-Membered Heterocycles Fused to One Benzene Ring. Benzodiazepines. Heterocycles Fused to Two Benzene Rings. beta-Lactam Antibiotics. Miscellaneous Fused Heterocycles. Indexes. Errata for Volume 1 of Organic Chemistry of Drug Synthesis.
巻冊次

Vol. 3 ISBN 9780471092506

内容説明

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

目次

Alicyclic and Cyclic Compounds. Phenethyl and Phenoxypropanolamines. Arylaliphatic Compounds. Monocyclic Aromatic Agents. Polycyclic Aromatic Compounds. Steroids. Compounds Related to Morphine. Five-Membered Heterocycles. Six-Membered Heterocycles. Five-Membered Heterocycles Fused to Benzene. Benzofused Six-Membered Heterocycles. Beta Lactams. Miscellaneous Fused Heterocycles. Indexes.
巻冊次

Vol. 6 ISBN 9780471245100

内容説明

Drug synthesis is a multi-billion industry. New drugs can make or break pharmaceutical firms as well as helping untold numbers of people as witnessed by the news coverage given the impotence drug. This volume will continue the successful series focusing on the synthesis of medicinal agents. Covering the literature from 1994 to 1998, the book targets practitioners in the field who seek a quick overview of the synthetic routes which have been used to access specific classes of therapeutic agents.

目次

Open--Chain Compounds. Monocyclic Aromatics. Carbocyclic Compounds. Five--Membered Heterocycles. Six-- and Seven--Membered Heterocycles. Five--Membered Heterocycles Fused to One Benzene Ring. Six--Membered Heterocycles Fused to One Benzene Ring. Beta Lactam Antibiotics. Bicyclic Fused Heterocycles. Polycyclic Fused Heterocycles. Indexes.
巻冊次

[Vol. 1] ISBN 9780471521419

内容説明

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

目次

  • A Case Study in Molecular Manipulation: The LocalAnesthetics. Monocyclic Alicyclic Compounds. Benzyl and Benzhydryl Derivatives. Penethyl and Phenylpropylamines. Arylacetic and Arylpropionic Acids. Arylethylenes and Their Reduction Products. Monocyclic Aromatic Compounds. Polycyclic Aromatic Compounds. Steroids. Tetracyclines. Acyclic Compounds. Five-Membered Heterocycles. Six-Membered Heterocycles. Derivatives of Morphine, Morphinan, and Benzomorphan
  • 4-Phenylpiperidines. Five-Membered Heterocycles Fused to One Benzene Ring. Six-Membered Heterocycles Fused to One Benzene Ring. Benzodiazepines. Phenothiazines. Additional Heterocycles Fused to Two Benzene Rings. beta-Lactam Antibiotics. Miscellaneous Fused Heterocycles. Cross Index of Drugs. Glossary. Index.
巻冊次

Vol. 5 ISBN 9780471589594

内容説明

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

目次

Acyclic and Alicyclic Compounds. Monocyclic Aromatic Compounds. Polycyclic Aromatic and Hydroaromatic Compounds. Steroids. Five-Membered Heterocycles. Six-Membered Heterocycles. Five-Membered Benzoheterocycles. Six- and Seven-Membered Benzoheterocycles. Bicyclic Fused Heterocycles. Beta Lactams. Miscellaneous Fused Heterocycles. Indexes.

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