Prostaglandins, leukotrienes, and lipoxins : biochemistry, mechanism of action, and clinical applications
Author(s)
Bibliographic Information
Prostaglandins, leukotrienes, and lipoxins : biochemistry, mechanism of action, and clinical applications
（GWUMC Department of Biochemistry annual spring symposia）
Plenum Press, c1985
Available at 13 libraries
Note
Based on the 4th International Spring Symposium on Health Sciences held in Washington, D.C. in May 1984
Includes bibliographies and index
Description and Table of Contents
Table of Contents
I - General Biochemistry and Enzymology of Prostaglandins, Leukotrienes, and Lipoxins.- 1. Lipoxins: A Novel Series of Biologically Active Compounds.- 2. Occurrence of Leukotrienes in Rat Brain: Evidence for a Neuroendocrine Role of Leukotriene C4.- 3. Properties of Prostaglandin-Biosynthesizing Enzymes.- 4. A Two Receptor Model for the Mechanism of Action of Prostaglandins in the Renal Collecting Tubule.- 5. Prostaglandin Endoperoxide Synthase from Human Cell Line LU-65.- 6. Coronary Arterial Prostacyclin Synthetase and Prostaglandin E2 Isomerase Activities.- 7. Glutathione Transferases Catalyzing Leukotriene C Synthesis and Metabolism of Leukotrienes C4 and E4in Vivo and in Vitro.- 8. Formation and Role of Lipoxygenase Products in Human Platelets.- 9. Lipoxygenation of Mitochondrial Membranes by Reticulocyte Lipoxygenase.- 10. The Major Pathway for Leukotriene B4 Catabolism in Human Polymorphonuclear Leukocytes Involves ?-Oxidation by a Cytochrome P-450 Enzyme.- 11. Hematin-Assisted Intramolecular Oxygen Transfer Mechanism is Involved in the Formation of 8-Hydroxy-l 1,12-epoxyeicosa-5,9,14-trienoic Acid (8H-11,12-EPETE) from 12-HPETE.- II - Regulatory Mechanisms in Eicosanoid Release and Metabolism.- 12. Molecular Mechanisms of the Modulation of Phospholipid Metabolism by Glucocorticoids.- 13. Transmembrane Signal in the Secretory Process of A23187-Stimulated Human Leukocytes: A Study of Eicosanoid Release.- 14. Postphospholipase Activation of Lipoxygenase/Leukotriene Systems.- 15. Regulation of Cyclooxygenase Synthesis in Vascular Smooth Muscle Cells by Epidermal Growth Factor.- 16. Fuel Metabolism as a Determinant of Arachidonic Acid Release and Oxygenation: Studies with Intact Rat Islets of Langerhans.- 17. Regulation of Differentiation of Canine Kidney (MDCK) Cells by Prostaglandins.- 18. Human Trabecular Meshwork Cells: Arachidonic Acid Metabolism and Prostaglandin Release.- 19. Prostacyclin Can Inhibit DNA Synthesis in Vascular Smooth Muscle Cells.- 20. Quantitation of Arachidonate Released during the Platelet Phosphatidylinositol Response to Thrombin.- 21. Phospholipases in the Macrophage.- 22. Lipid Bodies: Widely Distributed Cytoplasmic Structures That Represent Preferential Nonmembrane Repositories of Exogenous [3H] Arachidonic Acid Incorporated by Mast Cells, Macrophages, and Other Cell Types.- 23. Differences between the Effects of f-Met-Leu-Phe and Leukotriene B4 on Phosphoinositide Turnover and Their Relationship to Calcium Mobilization and Protein Kinase C Activation.- 24. Prostaglandylinositol Cyclic Phosphate: An Antagonist to Cyclic AMP.- III - Cardiovascular-Pulmonary Interactions of Prostaglandins, Prostacyclin, and Leukotrienes.- 25. Regulatory Mechanisms in Prostacyclin-Blood Vessel Interactions.- 26. A Comparison of the Contractile Responses of Rodent and Human Pulmonary Vascular Segments to Eicosanoids.- 27. Leukotriene C4 is Released from the Anaphylactic Heart: A Case for Its Direct Negative Inotropic Effect.- 28. Comparative Responses to Leukotriene D4 in the Sheep and Cat.- 29. Platelet-Activating Factor as a Modulator of Cardiac and Coronary Functions.- 30. Distinct Sulfidopeptide Leukotriene Receptors.- 31. Some Novel Aspects of the Function of Prostaglandin E2 in the Coronary Circulation.- 32. Prostaglandin H2 Causes Calcium Mobilization in Intact Human Platelets.- 33. Control of Ca2+ Mobilization and Polyphosphoinositide Metabolism in Platelets by Prostacyclin.- 34. Heme-Polyenoic Acid Interaction and Prostaglandin Synthesis.- 35. Cardiac Effects of Peptidoleukotrienes.- 36. Effects of Selenium Deficiency on Arachidonic Acid Metabolism and Aggregation in Rat Platelets.- 37. Different Functions of Phosphoinositide Turnover and Arachidonate Metabolism for Platelet Activation.- 38. Comparative Absorption and Lymphatic Transport of (?-3) Eicosapentaenoic Acid, (?-6) Arachidonic Acid, and (?-9) Oleic Acid.- IV - Recent Clinical Applications of Eicosanoids.- 39. Status of Clinical Trials Evaluating Eicosanoids in Atherosclerotic Vascular Disease and Thrombosis.- 40. Eicosanoids and Allograft Rejection.- 41. Prostaglandins in Human Seminal Fluid and Its Relation to Fertility.- 42. Arachidonate Lipoxygenase Products and Psoriasis.- 43. Coronary Leukotriene Levels and Myocardial Ischemia.- 44. Decreased Concentrations of Prostaglandin F2? Alpha in Delayed Labor: A Model for Studies on the Control of Prostaglandin Production by the Uterus.- 45. The Differentiated Contractile Effects of Prostaglandins on the Various Segments of the Pregnant Human Uterus.- V - Immune Reactions, Neoplasia, And Inflammatory Processes.- 46. Membrane Events and Guanylate Cyclase Activation in Mitogen-Stimulated Lymphocytes.- 47. Biochemical Cascade Involved in Mast Cell Activation for Mediator Release.- 48. Stimulation of Lymphocyte Guanylate Cyclase by Arachidonic Acid and HETEs.- 49. Release of Leukotrienes B4 and D4 by the Anaphylactic Guinea Pig Lung in Vitro.- 50. Mechanisms Involved in the Mediation of Contractions of Airway Smooth Muscle to Arachidonate Metabolites and Other Spasmogens.- 51. Macrophage Fc?2b Receptor Expression and Receptor-Mediated Phospholipase Activity: Feedback Regulation by Metabolites of Arachidonic Acid.- 52. Differential Effects of Leukotriene B4 and Its Analogues on Suppressor and Helper Cell function.- 53. Eicosanoid Precursor Fatty Acids in Plasma Phospholipids and Arachidonate Metabolism in Polymorphonuclear Leukocytes in Asthma.- 54. Induction of Suppressor T Cells in Vitro by Arachidonic Acid Metabolites Issued from the Lipoxygenase Pathway.- VI - Antiinflammatory Drugs And Inhibitors of Cyclooxygenase and Lipoxygenase Systems.- 55. Novel Aspects of Aspirin Action.- 56. Cyclooxygenase Inhibitors: An Overview.- 57. Comparative Biochemistry of Lipoxygenase Inhibitors.- 58. Inhibitors of Arachidonic Acid Metabolism Inhibit Tumor-Promoter-Stimulated Chemiluminescence in Murine Keratinocytes.- 59. Cyclooxygenase Inhibitors: Beneficial Effects on Tumor Metastasis in Rats.- 60. Arylmethyl Phenyl Ethers: A New Class of Specific Inhibitors of 5-Lipoxygenase.- 61. Relationship between Drug Absorption, Inhibition of Cyclooxygenase and Lipoxygenase Pathways, and Development of Gastric Mucosal Damage by Nonsteroidal Antiinflammatory Drugs in Rats and Pigs.- 62. Biosynthesis of Leukotriene B4 in Human Leukocytes: Demonstration of a Calcium-Dependent 5-Lipoxygenase.- 63. Novel Synthesis of Potent Site-Specific Phospholipase A2 Inhibitors.- Participants.
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