Prostaglandins, leukotrienes, and lipoxins : biochemistry, mechanism of action, and clinical applications
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Bibliographic Information
Prostaglandins, leukotrienes, and lipoxins : biochemistry, mechanism of action, and clinical applications
（GWUMC Department of Biochemistry annual spring symposia）
Plenum Press, c1985
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Based on the 4th International Spring Symposium on Health Sciences held in Washington, D.C. in May 1984
Includes bibliographies and index
Description and Table of Contents
Table of Contents
I - General Biochemistry and Enzymology of Prostaglandins, Leukotrienes, and Lipoxins.- 1. Lipoxins: A Novel Series of Biologically Active Compounds.- 2. Occurrence of Leukotrienes in Rat Brain: Evidence for a Neuroendocrine Role of Leukotriene C4.- 3. Properties of Prostaglandin-Biosynthesizing Enzymes.- 4. A Two Receptor Model for the Mechanism of Action of Prostaglandins in the Renal Collecting Tubule.- 5. Prostaglandin Endoperoxide Synthase from Human Cell Line LU-65.- 6. Coronary Arterial Prostacyclin Synthetase and Prostaglandin E2 Isomerase Activities.- 7. Glutathione Transferases Catalyzing Leukotriene C Synthesis and Metabolism of Leukotrienes C4 and E4in Vivo and in Vitro.- 8. Formation and Role of Lipoxygenase Products in Human Platelets.- 9. Lipoxygenation of Mitochondrial Membranes by Reticulocyte Lipoxygenase.- 10. The Major Pathway for Leukotriene B4 Catabolism in Human Polymorphonuclear Leukocytes Involves ?-Oxidation by a Cytochrome P-450 Enzyme.- 11. Hematin-Assisted Intramolecular Oxygen Transfer Mechanism is Involved in the Formation of 8-Hydroxy-l 1,12-epoxyeicosa-5,9,14-trienoic Acid (8H-11,12-EPETE) from 12-HPETE.- II - Regulatory Mechanisms in Eicosanoid Release and Metabolism.- 12. Molecular Mechanisms of the Modulation of Phospholipid Metabolism by Glucocorticoids.- 13. Transmembrane Signal in the Secretory Process of A23187-Stimulated Human Leukocytes: A Study of Eicosanoid Release.- 14. Postphospholipase Activation of Lipoxygenase/Leukotriene Systems.- 15. Regulation of Cyclooxygenase Synthesis in Vascular Smooth Muscle Cells by Epidermal Growth Factor.- 16. Fuel Metabolism as a Determinant of Arachidonic Acid Release and Oxygenation: Studies with Intact Rat Islets of Langerhans.- 17. Regulation of Differentiation of Canine Kidney (MDCK) Cells by Prostaglandins.- 18. Human Trabecular Meshwork Cells: Arachidonic Acid Metabolism and Prostaglandin Release.- 19. Prostacyclin Can Inhibit DNA Synthesis in Vascular Smooth Muscle Cells.- 20. Quantitation of Arachidonate Released during the Platelet Phosphatidylinositol Response to Thrombin.- 21. Phospholipases in the Macrophage.- 22. Lipid Bodies: Widely Distributed Cytoplasmic Structures That Represent Preferential Nonmembrane Repositories of Exogenous [3H] Arachidonic Acid Incorporated by Mast Cells, Macrophages, and Other Cell Types.- 23. Differences between the Effects of f-Met-Leu-Phe and Leukotriene B4 on Phosphoinositide Turnover and Their Relationship to Calcium Mobilization and Protein Kinase C Activation.- 24. Prostaglandylinositol Cyclic Phosphate: An Antagonist to Cyclic AMP.- III - Cardiovascular-Pulmonary Interactions of Prostaglandins, Prostacyclin, and Leukotrienes.- 25. Regulatory Mechanisms in Prostacyclin-Blood Vessel Interactions.- 26. A Comparison of the Contractile Responses of Rodent and Human Pulmonary Vascular Segments to Eicosanoids.- 27. Leukotriene C4 is Released from the Anaphylactic Heart: A Case for Its Direct Negative Inotropic Effect.- 28. Comparative Responses to Leukotriene D4 in the Sheep and Cat.- 29. Platelet-Activating Factor as a Modulator of Cardiac and Coronary Functions.- 30. Distinct Sulfidopeptide Leukotriene Receptors.- 31. Some Novel Aspects of the Function of Prostaglandin E2 in the Coronary Circulation.- 32. Prostaglandin H2 Causes Calcium Mobilization in Intact Human Platelets.- 33. Control of Ca2+ Mobilization and Polyphosphoinositide Metabolism in Platelets by Prostacyclin.- 34. Heme-Polyenoic Acid Interaction and Prostaglandin Synthesis.- 35. Cardiac Effects of Peptidoleukotrienes.- 36. Effects of Selenium Deficiency on Arachidonic Acid Metabolism and Aggregation in Rat Platelets.- 37. Different Functions of Phosphoinositide Turnover and Arachidonate Metabolism for Platelet Activation.- 38. Comparative Absorption and Lymphatic Transport of (?-3) Eicosapentaenoic Acid, (?-6) Arachidonic Acid, and (?-9) Oleic Acid.- IV - Recent Clinical Applications of Eicosanoids.- 39. Status of Clinical Trials Evaluating Eicosanoids in Atherosclerotic Vascular Disease and Thrombosis.- 40. Eicosanoids and Allograft Rejection.- 41. Prostaglandins in Human Seminal Fluid and Its Relation to Fertility.- 42. Arachidonate Lipoxygenase Products and Psoriasis.- 43. Coronary Leukotriene Levels and Myocardial Ischemia.- 44. Decreased Concentrations of Prostaglandin F2? Alpha in Delayed Labor: A Model for Studies on the Control of Prostaglandin Production by the Uterus.- 45. The Differentiated Contractile Effects of Prostaglandins on the Various Segments of the Pregnant Human Uterus.- V - Immune Reactions, Neoplasia, And Inflammatory Processes.- 46. Membrane Events and Guanylate Cyclase Activation in Mitogen-Stimulated Lymphocytes.- 47. Biochemical Cascade Involved in Mast Cell Activation for Mediator Release.- 48. Stimulation of Lymphocyte Guanylate Cyclase by Arachidonic Acid and HETEs.- 49. Release of Leukotrienes B4 and D4 by the Anaphylactic Guinea Pig Lung in Vitro.- 50. Mechanisms Involved in the Mediation of Contractions of Airway Smooth Muscle to Arachidonate Metabolites and Other Spasmogens.- 51. Macrophage Fc?2b Receptor Expression and Receptor-Mediated Phospholipase Activity: Feedback Regulation by Metabolites of Arachidonic Acid.- 52. Differential Effects of Leukotriene B4 and Its Analogues on Suppressor and Helper Cell function.- 53. Eicosanoid Precursor Fatty Acids in Plasma Phospholipids and Arachidonate Metabolism in Polymorphonuclear Leukocytes in Asthma.- 54. Induction of Suppressor T Cells in Vitro by Arachidonic Acid Metabolites Issued from the Lipoxygenase Pathway.- VI - Antiinflammatory Drugs And Inhibitors of Cyclooxygenase and Lipoxygenase Systems.- 55. Novel Aspects of Aspirin Action.- 56. Cyclooxygenase Inhibitors: An Overview.- 57. Comparative Biochemistry of Lipoxygenase Inhibitors.- 58. Inhibitors of Arachidonic Acid Metabolism Inhibit Tumor-Promoter-Stimulated Chemiluminescence in Murine Keratinocytes.- 59. Cyclooxygenase Inhibitors: Beneficial Effects on Tumor Metastasis in Rats.- 60. Arylmethyl Phenyl Ethers: A New Class of Specific Inhibitors of 5-Lipoxygenase.- 61. Relationship between Drug Absorption, Inhibition of Cyclooxygenase and Lipoxygenase Pathways, and Development of Gastric Mucosal Damage by Nonsteroidal Antiinflammatory Drugs in Rats and Pigs.- 62. Biosynthesis of Leukotriene B4 in Human Leukocytes: Demonstration of a Calcium-Dependent 5-Lipoxygenase.- 63. Novel Synthesis of Potent Site-Specific Phospholipase A2 Inhibitors.- Participants.
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